Optimal windows for obtaining optical data for characterization of tissue samples
First Claim
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1. A method of identifying a characteristic of a region of a tissue sample, the method comprising the steps of:
- (a) applying a contrast agent comprising acetic acid to a region of a tissue sample;
(b) obtaining at least one optical signal from the region within a window of time, wherein the window of time begins at about 30 seconds following application of the contrast agent and ends at about 130 seconds following application of the contrast agent, and wherein the at least one optical signal comprises at least one of;
(i) a fluorescence signal; and
(ii) a reflectance signal; and
(c) identifying a characteristic of the region based at least in part on the at least one optical signal.
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Abstract
The invention provides methods for determining a characteristic of a tissue sample, such as a state of health, using spectral data and/or images obtained within an optimal period of time following the application of a chemical agent to the tissue sample. The invention provides methods of determining such optimal windows of time. Similarly, the invention provides methods of determining other criteria for triggering the acquisition of an optical signal for classifying the state of health of a region of a tissue sample.
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Citations
24 Claims
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1. A method of identifying a characteristic of a region of a tissue sample, the method comprising the steps of:
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(a) applying a contrast agent comprising acetic acid to a region of a tissue sample;
(b) obtaining at least one optical signal from the region within a window of time, wherein the window of time begins at about 30 seconds following application of the contrast agent and ends at about 130 seconds following application of the contrast agent, and wherein the at least one optical signal comprises at least one of;
(i) a fluorescence signal; and
(ii) a reflectance signal; and
(c) identifying a characteristic of the region based at least in part on the at least one optical signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification