PGD2 receptor antagonistic pharmaceutical compositions
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Abstract
Compounds of the general formula (I) which are metabolically stable and have an antagonistic activity against PGD2 receptor:
wherein Y is bicyclic ring; R1 is optionally substituted heteroaryl; R2 is hydrogen, etc.; R3 is —CH2—CH2—CH2—CH2—CH═CH—COOR4, —CH2—CH2—CH2—CH2—X1—CH2—COOR4, —CH2—CH═CH—CH2—X1—CH2—COOR4 or —CH2—CH2—CH2—COOR4; R4 is hydrogen, etc.; X1 is —O—, etc.
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Citations
16 Claims
- 1. A compound represented by the formula (I):
- 6. A pharmaceutical composition comprising an auxiliary component and a compound of Formula (I):
- 7. A method for treating nasal blockage, allergic conjunctivitis or allergic rhinitis, which comprises administrating a compound of Formula (I):
Specification