Nanotechnology for drug delivery, contrast agents and biomedical implants

• US 6,933,331 B2
• Filed: 02/20/2001
• Issued: 08/23/2005
• Est. Priority Date: 05/22/1998
• Status: Expired due to Term

• Current Assignee: PPG Industries Ohio Incorporated (Nouryon BV)
• Original Assignee: NanoProducts Corporation (Nouryon BV)
• Inventors: Yadav, Tapesh, Kostelecky, Clayton
• Primary Examiner(s): Wyrozebski, Katarzyna
• Application Number:
  US09/790,036
• Publication Number:
  US 20020014182A1
• Time in Patent Office: 1,645 Days
• Field of Search: 524/435, 524/403, 524/406, 524/408, 524/434, 524/436, 523/210, 523/105, 523/137, 523/200, 523/375, 424/1.29, 424/1.33, 424/1.61, 424/1.65, 424/9.322, 424/9.323, 424/9.411, 424/408, 424/417, 424/421
• US Class Current: 523/210
• CPC Class Codes: B01J 12/005 carried out at high temperatures, e.g. by pyrolysis
• CPC Class Codes: B01J 12/02 for obtaining at least one reaction product which, at normal temperature, is in the solid state
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• CPC Class Codes: B01J 2219/00155 using insulating materials or refractories
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• CPC Class Codes: B01J 2219/0894 Processes carried out in the presence of a plasma
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• CPC Class Codes: B22F 1/054 Nanosized particles
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• CPC Class Codes: B22F 1/102 Metallic powder coated with organic material
• CPC Class Codes: B22F 1/12 Metallic powder containing non-metallic particles containing lubricating or binding agents or organic material B22F1/10
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• CPC Class Codes: B82Y 30/00 : Nanotechnology for materials or surface science, e.g. nanocomposites
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• CPC Class Codes: C04B 41/009 : characterised by the material treated
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• CPC Class Codes: C04B 41/90 : at least one coating being a metal
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• CPC Class Codes: C08K 3/01 : characterized by their specific function
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Abstract

A nanocomposite structure comprising a nanostructured filler or carrier intimately mixed with a matrix, and methods of making such a structure. The nanostructured filler has a domain size sufficiently small to alter an electrical, magnetic, optical, electrochemical, chemical, thermal, biomedical, or tribological property of either filler or composite by at least 20%.

Claims

1. A biomedical material for administration in a human or animal comprising:

nanostructured ceramic powders whose surface has been reacted with a precursor;

a solid matrix;

wherein the nanostructured ceramic powders have been embedded in the solid matrix;

and

wherein the nanostructured ceramic powders have a domain size smaller than a capillary blood vessel.

2. The composition of matter of claim 1, wherein the nanostructured ceramic powders comprise of coated nanostructured ceramic powders.

3. The composition of matter of claim 2, wherein the coating comprises a polymer or a phase that is compatible with the solid matrix composition.

4. The composition of matter of claim 1 further comprising a coating formed on the nanostructured ceramic powders wherein the nanostructured ceramic powders are water-insoluble and the coated material is water-soluble.

5. The biomedical material of claim 2 wherein the coating functions to perform a function selected from the group consisting of:

selective filtering, transfer, capture, and removal of species and molecules from blood into the filler powders.

6. The composition of matter of claim 1 wherein:

the material is selected from the group consisting of magnetic, photocatalytic, radioactive and thermally sensitive nanopowders, and

the nanopowders are a vehicle to transport a species selected from the group consisting of a drug, a marker, a genetic material and a culture material.

7. The composition of matter of claim 1 wherein the powders are an oxide.

8. The composition of matter of claim 1 wherein the powders comprise one or more elements selected from the group consisting of:

barium, cesium, cobalt, copper, hafnium, neodymium, gadolinium, manganese, iron, lanthanum, silver, vanadium, zinc and zirconium.

9. The biomedical material of claim 1 wherein the powders comprise a radioactive element.

10. The biomedical material of claim 1 wherein the powders comprise a material selected from the group consisting of:

genetic material and culture material.

11. A biomedical material for administration in a human or animal comprising;

nanostructured ceramic powders whose surface has been reacted with a precursor;

a solid matrix;

wherein the nanostructured ceramic powders have been embedded in the solid matrix;

wherein the nanostructured ceramic powders have a domain size smaller than a capillary blood vessel; and

a drug, wherein the nanostructured ceramic powders function as a carrier for the drug.

12. A biomedical material for administration in a human or animal comprising:

nanostructured ceramic powders whose surface has been reacted with a precursor;

a solid matrix;

wherein the nanostructured ceramic powders have been embedded in the solid matrix;

wherein the nanostructured ceramic powders have a domain size smaller than a capillary blood vessel; and

a coating formed on the nanostructured ceramic powders wherein the nanostructured powders are water-soluble and the coated material is water-insoluble.

13. A biomedical material for administration in a human or animal comprising:

nanostructured ceramic powders whose surface has been reacted with a precursor;

a solid matrix;

wherein the nanostructured ceramic powders have been embedded in the solid matrix;

wherein the nanostructured ceramic powders have a domain size smaller than a capillary blood vessel; and

wherein the material delivers a time-release drug.

14. A biomedical material for administration in a human or animal comprising:

nanostructured ceramic powders whose surface has been reacted with a precursor;

a solid matrix;

wherein the nanostructured ceramic powders have been embedded in the solid matrix;

wherein the nanostructured powders have a domain size smaller than a capillary blood vessel; and

wherein the nanostructured ceramic powders are responsive to an externally applied magnetic field so as to preferentially gather and function in locations having an applied magnetic field.

15. The biomedical material of claim 14 further comprising a biologically active agent releasably attached to the nanostructured powders so as to release the biologically active agent in the vicinity of the applied magnetic field.

16. A biomedical material for administration in a human or animal comprising:

nanostructured ceramic powders whose surface has been reacted with a precursor;

a solid matrix;

wherein the nanostructured ceramic powders have been embedded in the solid matrix;

wherein the nanostructured ceramic powders have a domain size smaller than a capillary blood vessel; and

wherein the powders comprise a marker.

17. The composition of matter of claim 16 wherein the marker is a marker for magnetic resonance imaging.

18. The composition of matter of claim 16 wherein the powders comprise a ferrite.

19. A biomedical material for administration in a human or animal comprising:

a filler of powders whose surfaces have been reacted with a precursor;

a solid matrix;

wherein the filler of powders is embedded in the solid matrix;

wherein the filler powders are nanostructured;

the loading of the filler is less than 95 volume percent; and

wherein the filler composition comprises a ceramic and the composition is administered in a human or animal.

20. A material for biological application comprising:

nanostructured inorganic powders having a domain size smaller than 100 nm;

wherein the surface of the nanostructured inorganic powders has been reacted with a precursor to form a coating;

wherein the coating comprises a polymer and the coated nanostructured inorganic powders serve as a time-release delivery of a drug.

21. A biomedical material for administration in a human or animal comprising:

nanostructured metallic powders whose surfaces have been reacted with a precursor;

a solid matrix;

wherein the nanostructured metallic powders are embedded in the solid matrix;

a solid composite comprising a matrix and nanostructured metallic powders; and

wherein the nanostructured metallic powders have a domain size smaller than a capillary blood vessel.

22. The composition of matter of claim 21 wherein the powders comprise copper.

23. The composition of matter of claim 21 wherein the powders comprise silver.

24. A nanostructured material comprising:

water-soluble nanostructured inorganic powders having a domain size smaller than 100 nm;

wherein the surfaces of the nanostructured inorganic powders have been reacted with a precursor;

wherein the nanostructured inorganic powders become water-insoluble after the nanostructured inorganic powders have been reacted with the precursor.

25. A nanostructured material comprising:

water-insoluble nanostructured inorganic powders having a domain size smaller than 100 nm;

wherein the surfaces of the nanostructured inorganic powders have been reacted with a precursor;

a coating on the powders, wherein the coating comprises a metallic species and the coated powders are a vehicle to deliver biologically active species;

wherein the nanostructured inorganic powders becomes water-soluble after the nanostructured inorganic powders have been reacted with the precursor.

26. The composition of matter of claim 25 wherein the nanostructured inorganic powders that have been reacted with a precursor comprise one or more elements from the group consisting of aluminum, copper, iron, magnesium, silicon, silver, gold, nickel, palladium, titanium, tin, zinc, and zirconium.

27. A composite comprising the composition of matter of claim 25.

28. A product comprising the composition of matter of claim 25.