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Monoclonal antibodies with reduced immunogenicity

  • US 6,936,698 B2
  • Filed: 07/16/2001
  • Issued: 08/30/2005
  • Est. Priority Date: 04/28/1998
  • Status: Expired due to Fees
First Claim
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1. An antibody comprising:

  • a) a variable region comprising six complementarity determining regions (CDRs) from an antigen-specific donor antibody of a rodent and acceptor framework comprising amino acid residues from an Old World Ape, wherein at least one CDR-contacting amino acid residue from the acceptor framework is replaced with a corresponding residue from the donor framework, and wherein said CDR-contacting residue contacts a CDR residue within said antibody by the group selected from coming within the van der Waals radius of said CDR residue, a salt bridge and a hydrophobic interaction; and

    b) at least one constant region from human, and wherein said antibody has a specific binding avidity that is within about three-fold of the specific binding avidity of said antigen-specific donor antibody.

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