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Localized delivery of drug agents

  • US 6,939,320 B2
  • Filed: 06/27/2001
  • Issued: 09/06/2005
  • Est. Priority Date: 05/18/1998
  • Status: Expired due to Term
First Claim
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1. A medical device, comprising:

  • a substrate that is expandable from a compressed state to an expanded state;

    a coating on said substrate, said coating having a drug agent incorporated therein, wherein said drug agent comprises an anti-proliferative agent and is incorporated in said coating prior to delivering said medical device to a target location within a mammalian body; and

    an elastic sheath over said coating, said elastic sheath being expandable from a compressed state to an expanded state and having at least one perforation therein;

    wherein when said substrate is in a compressed state, said elastic sheath is in a compressed state and said at least one perforation is substantially closed such that said drug agent does not pass through said at least one perforation; and

    wherein when said substrate is in an expanded state, said elastic sheath is in an expanded state and said at least one perforation is substantially open such that said drug agent passes through said at least one perforation.

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