Method for reducing restenosis in the presence of an intravascular stent
First Claim
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1. A method comprising:
- positioning a first electrode near an implanted intravascular stent;
positioning a second electrode at a different position from the first electrode; and
delivering at least one pulse of electrical energy between the first and second electrodes at a repetition rate that is less than or equal to the order of a frequency between heart depolarizations.
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Abstract
A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
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Citations
76 Claims
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1. A method comprising:
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positioning a first electrode near an implanted intravascular stent;
positioning a second electrode at a different position from the first electrode; and
delivering at least one pulse of electrical energy between the first and second electrodes at a repetition rate that is less than or equal to the order of a frequency between heart depolarizations. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method comprising:
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positioning a first electrode near an implanted intravascular stent;
positioning a second electrode at a different position from the first electrode;
measuring an impedance between the first and second electrodes;
determining a desired energy level, using the measured impedance, for inhibiting or reducing stenosis; and
delivering electrical energy at the desired energy level between the first electrode and the second electrode to inhibit or reduce stenosis. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 69, 70, 71, 72, 73, 74, 75, 76)
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31. A method comprising:
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positioning a first electrode near an implanted intravascular stent;
positioning a second electrode at a different position from the first electrode;
measuring an impedance between the first and second electrodes;
determining a desired energy level, using the measured impedance, wherein the desired energy level is appropriate for inhibiting or reducing stenosis without affecting nearby myocardial tissue;
delivering electrical energy at the desired energy level between the first and second electrodes. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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50. A method comprising:
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positioning a first electrode near an implanted intravascular stent;
positioning a second electrode at a different position from the first electrode;
measuring an impedance using the first and second electrodes;
determining a desired energy level, using the measured impedance, in which the desired energy level is determined using a predetermined desired current density between the first and second electrodes; and
delivering electrical energy between the first and second electrodes at the desired energy level to inhibit or reduce stenosis. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58)
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59. A method comprising:
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positioning a first electrode near an implanted intravascular stent;
positioning a second electrode at a different position from the first electrode; and
delivering a substantially constant DC current between the first electrode and the second electrode;
measuring an impedance using the substantially constant DC current;
determining a desired energy level, using the measured impedance, for inhibiting or reducing stenosis; and
delivering electrical energy between the first and second electrodes at the desired energy level to inhibit or reduce stenosis. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 67, 68)
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Specification