Coated vascular grafts and methods of use
First Claim
1. A vascular graft comprising:
- a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and
a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane;
wherein the coating comprises a polyurethane urea, wherein said first coating has a thickness of about 12 μ
m.
3 Assignments
0 Petitions
Accused Products
Abstract
A vascular graft, such as an AAA stent graft, includes a core zone of PET fabric with a non-porous coating comprising a polyurethane, such as Thoralon®, disposed on at least one surface. The coating provides a barrier to prevent short and long term leakage of fluids through the pores of the PET fabric core zone. A method for sealing the pores of a porous PET graft includes the step of coating at least one surface of said graft with at least one polyurethane, or mixtures and combinations thereof. Preferably, the coating is Thoralon®. A method for making a vascular prosthesis includes the steps of providing a core zone of PET fabric, and coating at least one surface of the core zone with at least one polyurethane, or mixtures and combinations thereof, such as Thoralon®. Finally, a method of repairing or treating a defective vessel includes the step of reinforcing or replacing the defective vessel with a graft according to the invention.
196 Citations
13 Claims
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1. A vascular graft comprising:
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a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and
a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane;
wherein the coating comprises a polyurethane urea, wherein said first coating has a thickness of about 12 μ
m.
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2. A vascular graft comprising:
a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and
a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane;
wherein the coating comprises a polyetherurethane urea blended with a siloxane containing a surface modifying additive, wherein said first coating has a thickness of about 12 μ
m.
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3. A vascular graft comprising:
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a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and
a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane;
wherein said at least one polyurethane comprises a soft segment and a hard segment, wherein said first coating has a thickness of about 12 μ
m. - View Dependent Claims (4, 5, 6, 7)
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8. A vascular graft comprising:
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a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and
a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane;
wherein the coating comprises a polyurethane urea, wherein said first coating has a thickness in a range of about 4 μ
m to about 5 μ
m.
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9. A vascular graft comprising:
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a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and
a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane;
wherein the coating comprises a polvetherurethane urea blended with a siloxane containing a surface modifying additive, wherein said first coating has a thickness in a range of about 4 μ
m to about 5 μ
m.
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10. A vascular graft comprising:
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a core zone comprising a PET fabric, said core zone having a first surface and a second surface opposing said first surface, wherein the first surface is a blood interface surface; and
a first non-porous coating disposed on said first surface and permeating into at least a portion of said core zone, such that said at least one portion of said core zone is impermeable, wherein said first coating comprises at least one polyurethane;
wherein said at least one polyurethane comprises a soft segment and a hard segment, wherein said first coating has a thickness in a range of about 4 μ
m to about 5 μ
m. - View Dependent Claims (11, 12, 13)
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Specification