Minimally compliant, volume efficient piston for osmotic drug delivery systems
First Claim
1. An osmotic delivery system comprising:
- a capsule, said capsule having an interior for holding a beneficial agent, said interior having an interior surface;
an osmotic agent located in said interior;
a semipermeable body in liquid communication with said capsule for permitting liquid to permeate through said semipermeable body to said osmotic agent; and
a piston having a length to total diameter ratio of about 1.1;
1 and a core-diameter-to-overall-diameter ratio of about 0.9;
1 located within said interior of said capsule, being movable with respect to said interior surface of said capsule, defining a movable seal with said interior surface of said capsule that separates said osmotic agent from said beneficial agent;
said osmotic agent located between said piston and said semipermeable body, said osmotic agent for imbibing fluid from a surrounding environment through said semipermeable body to cause said piston to move and, in turn, cause delivery of said beneficial agent from said capsule.
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Accused Products
Abstract
An osmotic pump having a minimally compliant, volume-efficient piston positioned within a capsule is provided. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length-to-total-diameter ratio of about 1.1:1 and a core-diameter-to-total-diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.
160 Citations
16 Claims
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1. An osmotic delivery system comprising:
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a capsule, said capsule having an interior for holding a beneficial agent, said interior having an interior surface;
an osmotic agent located in said interior;
a semipermeable body in liquid communication with said capsule for permitting liquid to permeate through said semipermeable body to said osmotic agent; and
a piston having a length to total diameter ratio of about 1.1;
1 and a core-diameter-to-overall-diameter ratio of about 0.9;
1 located within said interior of said capsule, being movable with respect to said interior surface of said capsule, defining a movable seal with said interior surface of said capsule that separates said osmotic agent from said beneficial agent;
said osmotic agent located between said piston and said semipermeable body, said osmotic agent for imbibing fluid from a surrounding environment through said semipermeable body to cause said piston to move and, in turn, cause delivery of said beneficial agent from said capsule. - View Dependent Claims (2, 3, 4, 5)
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6. An osmotic delivery system comprising:
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a piston having a length-to-overall-diameter ratio of about 1.1;
1 and a core-diameter-to-overall-diameter ratio of about 0.9;
1;
an osmotic agent; and
an enclosure having an interior holding said piston and said osmotic agent, said piston being movable with respect to said enclosure, and said enclosure having a semipermeable body in liquid communication with said osmotic agent for permitting liquid to permeate through said semipermeable body to said osmotic agent, said osmotic agent for imbibing fluid from a surrounding environment and causing said piston to move. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14)
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15. An osmotic delivery system comprising:
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a capsule having a tubular interior, said tubular interior having an interior surface;
a semipermeable body located at least partially within said tubular interior;
an osmotic agent located between said semipermeable body and a piston;
a beneficial agent located within said tubular interior; and
said piston located within said tubular interior, said piston having a length-to-overall-diameter ratio of about 1.1;
1 and a core-diameter-to-overall-diameter ratio of about 0.9;
1, said piston separating said beneficial agent from said osmotic agent, and being movable with respect to said interior surface of said tubular interior and with respect to said semipermeable body. - View Dependent Claims (16)
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Specification