Enantioselective oligomerization of α-hydroxy carboxylic acids and α-amino acids
First Claim
1. A process for the preparation of an oligomer, the process comprising:
- forming a reaction mixture comprising an enzyme, an enantiomeric mixture of an α
-amino acid or a derivative thereof, and an enantiomeric mixture of an α
-hydroxy carboxylic acid or a derivative thereof, wherein the α
-hydroxy carboxylic acid comprises 2-hydroxy-4-(methylthio)butyric acid or a derivative thereof; and
forming an oligomer from the reaction mixture, said oligomer incorporating one of the members of the enantiomeric mixture of the α
-amino acid or derivative thereof in preference to the other member. wherein the formed oligomer comprises an oligomer of two or more α
-amino acid monomers bonded to a residue of the α
-hydroxy carboxylic acid or a derivative thereof by an amide or ester linkage.
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Accused Products
Abstract
An enzymatic synthesis and composition of oligomers and co-oligomers comprised of α-hydroxy carboxylic acids and α-amino acids or peptides is disclosed. In a preferred embodiment, a α-hydroxy carboxylic acid with a specific chiral configuration is linked by an amide linkage to a α-amino acid specific with a specific chiral configuration or linked by an amide linkage to a peptide made up of α-amino acid monomers having identical chiral configurations. Proteolytic enzymes catalyze oligomerization of the α-hydroxy carboxylic acid and α-amino acid. The degree and distribution of oligomerization varies upon the type and concentrations of different reaction mixtures utilized and upon the length of allowed reaction time. The resultant oligomers may be provided to animals such as ruminants as bioavailable amino acid supplements that are resistant to degradation in the rumen and other animals such as swine, poultry and aquatic animals.
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Citations
1 Claim
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1. A process for the preparation of an oligomer, the process comprising:
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forming a reaction mixture comprising an enzyme, an enantiomeric mixture of an α
-amino acid or a derivative thereof, and an enantiomeric mixture of an α
-hydroxy carboxylic acid or a derivative thereof, wherein the α
-hydroxy carboxylic acid comprises 2-hydroxy-4-(methylthio)butyric acid or a derivative thereof; and
forming an oligomer from the reaction mixture, said oligomer incorporating one of the members of the enantiomeric mixture of the α
-amino acid or derivative thereof in preference to the other member.wherein the formed oligomer comprises an oligomer of two or more α
-amino acid monomers bonded to a residue of the α
-hydroxy carboxylic acid or a derivative thereof by an amide or ester linkage.
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Specification