Imaging probe

• US 6,940,070 B2
• Filed: 10/24/2002
• Issued: 09/06/2005
• Est. Priority Date: 10/25/2001
• Status: Active Grant

• Current Assignee: Nova R&D Incorporated (Kromek Group PLC)
• Original Assignee: Tumay O. Tumer
• Inventors: Tumer, Tumay O
• Primary Examiner(s): Gabor, Otilia
• Application Number:
  US10/279,003
• Publication Number:
  US 20030081716A1
• Time in Patent Office: 1,048 Days
• Field of Search: 250/370.09, 250/370.01, 250/366, 250/367, 250/368, 250/369, 250/363.03, 250/363.04, 250/252.1, 250/330, 378/4, 378/37, 378/98.8
• US Class Current: 250/370.09
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/508 for non-human patients
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00
• CPC Class Codes: G01T 7/00 Details of radiation-measuring instruments

Abstract

The design of a compact, handheld, solid-state and high-sensitivity imaging probe and a micro imager system is reported. These instruments can be used as a dedicated tool for detecting and locating sentinel lymph nodes and also for detecting and imaging radioactive material. The reported device will use solid state pixel detectors and custom low-noise frontend/readout integrated circuits. The detector will be designed to have excellent image quality and high spatial resolution. The imaging probes have two different embodiments, which are comprised of a pixelated detector array and a highly integrated readout system, which uses a custom multi-channel mixed signal integrated circuit. The instrument usually includes a collimator in front of the detector array so that the incident photons can be imaged. The data is transferred to an intelligent display system. A hyperspectral image can also be produced and displayed. These devices are designed to be portable for easy use.

Claims

1. A method of imaging a portion of a human body, the method comprising the steps of:

providing a radiopharmaceutical to said portion of said human body, said radiopharmaceutical producing radiation;

positioning a detection system proximate to said portion of said human body, wherein

said detection system is comprised of a compact and portable detector, wherein

said detector comprised of two dimensional plurality of pixels;

determining a direction and an energy for a portion of said radiation entering said detection system from a plurality of pixels;

processing said direction and energy data for said portion of radiation; and

displaying an image in real time of said portion of said human body, wherein said image is based on said processed direction and energy data.

2. The method of claim 1, wherein said portion of said human body is an organ.

3. The method of claim 1, wherein said portion of said human body is a breast.

4. The method of claim 1, further comprising using the image to determine the position of at least one section of said portion of the said living organism which emits gamma rays at a higher rate than the background and locating said section using rulings on a display.

5. The method of claim 1, wherein said imaging method produces a hyperspectral image.

6. The method of claim 1, further comprising a step of detecting at least one section of said portion of the said living organism which has higher uptake of the said radiopharmaceutical over the rest of the said portion.

7. The method of claim 1, wherein said imaging method uses a collimator to restrict the angle of the radiation for controlling the direction of the radiation that enters its aperture.

8. The medical imaging system of claim 1, wherein said radiation emitted from a radiopharmaceutical is selected from the group of particles consisting of photon, electron, positron, proton and alpha particle.

9. A medical imaging system for imaging a portion of a living organism, said portion treated with a radiopharmaceutical said radiopharmaceutical emitting radiation, comprising:

a detector comprised of a plurality of two-dimensional pixels, wherein an entrance aperture of said detector is external to said living organism and proximate to said portion of said living organism, wherein said emitted radiation enter into said detector and are absorbed within said detector;

a multi channel readout system coupled to at least one said pixel of said detector;

a processor coupled to said multi-channel readout system; and

a monitor coupled to said processor, said monitor displaying an image of radiation coming from the said portion of said living organism in real time.

10. The medical imaging system of claim 9;

wherein a portion of said emitted radiation enters the said detector, makes a photoelectric interaction wherein a position of interaction is determined from energy deposited inside at least one of the said pixels of the said detector and wherein the position of interaction is used to determine direction of the incident radiation.

11. The medical imaging system of claim 9, further comprising a collimator to restrict an angle of radiation incident on the said detector to determine the direction of the incident radiation.

12. The medical imaging system of claim 9, wherein said radiopharmaceutical is tagged with a radioactive material which is selected from the group consisting of thallium-201, technetium-99m, iodine-123, iodine-131, and fluorine-18.

13. The medical imaging system of claim 9, further comprising a handle for holding the said medical imaging system.

14. The medical imaging system of claim 9, wherein said detector is selected from at least one of the detector types including pad detectors, pixel detectors, double sided microstrip detectors, double sided strip detectors, and double sided pixel detectors.

15. The medical imaging system of claim 9, wherein both sides of the said detector contain said plurality of pixels.

16. The medical imaging system of claim 9, wherein said pixels are made from ohmic type electrodes.

17. The medical imaging system of claim 9, wherein said pixels are made from blocking type electrodes.

18. The medical imaging system of claim 9, wherein said plurality of pixels have a pitch varying from 0.01 to 10 mm.

19. The medical imaging system of claim 9, wherein there is at least one detector plane.

20. The medical imaging system of claim 9, wherein said detector material is selected from the group of detector materials consisting of Silicon, HPGe, BGO, CdWo4, CsF, NaI(Tl), CsI(Na), CsI(Tl), CdTe, CdZnTe, HgI₂, GaAs, and PbI₂.

21. The medical imaging system of claim 9, wherein said imaging system is made compact and portable.

22. The medical imaging system of claim 9, wherein said radiation emitted from a radiopharmaceutical is selected from the group of particles consisting of photon, electron, positron, proton and alpha particle.