Polymeric articles having a lubricious coating and method for making the same
First Claim
1. An ophthalmic device, comprising a core material and a lubricious coating,wherein said ophthalmic device having said lubricious coating thereon has an increased hydrophilicity characterized by an averaged contact angle of about 80 degrees or less, and wherein said lubricious coating comprises a capping layer of polyvinylpyrrolidone and at least one layer of a lubricious coating material selected from the group consisting of PAMAM dendrimers, PAAm-co-PAA, glycosaminoglycanes, fucoidan, poly-aspartic acid, poly-glutamic acid, carboxymethyl cellulose, carboxymethyl dextranes, alginates, pectins, gellan, carboxyalkyl chitins, carboxymethyl chitosans, sulfated polysaccharides, glucoproteins, and aminoalkylated polysaccharides.
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.
-
Citations
21 Claims
-
1. An ophthalmic device, comprising a core material and a lubricious coating,
wherein said ophthalmic device having said lubricious coating thereon has an increased hydrophilicity characterized by an averaged contact angle of about 80 degrees or less, and wherein said lubricious coating comprises a capping layer of polyvinylpyrrolidone and at least one layer of a lubricious coating material selected from the group consisting of PAMAM dendrimers, PAAm-co-PAA, glycosaminoglycanes, fucoidan, poly-aspartic acid, poly-glutamic acid, carboxymethyl cellulose, carboxymethyl dextranes, alginates, pectins, gellan, carboxyalkyl chitins, carboxymethyl chitosans, sulfated polysaccharides, glucoproteins, and aminoalkylated polysaccharides.
- 9. A ophthalmic device, comprising a core material and a lubricious coating, wherein said ophthalmic device having said lubricious coating thereon has an increased hydrophilicity characterized by an averaged contact angle of about 80 degrees or less, wherein said lubricious coating comprises a capping layer of polyvinylpyrrolidone or at least one layer of a lubricious coating material selected from the group consisting of PAMAM dendrimers, PAAm-co-PAA, glycosaminoglycanes, fucoidan, poly-aspartic acid, poly-glutamic acid, carboxymethyl cellulose, carboxymethyl dextranes, alginates, pectins, gellan, carboxyalkyl chitins, carboxymethyl chitosans, sulfated polysaccharides, glucoproteins, and aminoalkylated polysaccharides, and wherein said lubricious coating further comprises at least one layer of a polyionic material which is non-covalently bond to the lubricous material.
- 19. A ophthalmic device, comprising a core material and a lubricious coating, wherein said ophthalmic device having said lubricious coating thereon has an increased hydrophilicity characterized by an averaged contact angle of about 80 degrees or less, and wherein said lubricious coating comprises at least one layer of a lubricious coating material selected from the group consisting of alginates, PAH lactone, hyaluronic acid and salts thereof, PAMAM dendrimers, PAAm-co-PAA, chondroitin sulfate, chitosan, proteoglycans, and mixtures thereof.
Specification