Polymeric articles having a lubricious coating and method for making the same

• US 6,940,580 B2
• Filed: 01/08/2003
• Issued: 09/06/2005
• Est. Priority Date: 01/09/2002
• Status: Expired due to Term

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Lally, John Martin, Winterton, Lynn Cook, Qiu, Yongxing, Gabriel, Manal M.
• Primary Examiner(s): Tarazano, D. Lawrence
• Application Number:
  US10/338,631
• Publication Number:
  US 20030134132A1
• Time in Patent Office: 972 Days
• Field of Search: 351/160.H, 352/160.H, 428/413, 428/508, 428/532, 428/522
• US Class Current: 351/160.00H
• CPC Class Codes: A61L 2400/10 Materials for lubricating medical devices
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: G02B 1/043 Contact lenses
• CPC Class Codes: Y10T 428/31667 Next to addition polymer from unsaturated monomers, or aldehyde or ketone condensation product
• CPC Class Codes: Y10T 428/31884 Regenerated or modified cellulose
• CPC Class Codes: Y10T 428/31891 Where addition polymer is an ester or halide
• CPC Class Codes: Y10T 428/31935 Ester, halide or nitrile of addition polymer
• CPC Class Codes: Y10T 428/31971 Of carbohydrate

Abstract

The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.

Claims

1. An ophthalmic device, comprising a core material and a lubricious coating,

wherein said ophthalmic device having said lubricious coating thereon has an increased hydrophilicity characterized by an averaged contact angle of about 80 degrees or less, and wherein said lubricious coating comprises a capping layer of polyvinylpyrrolidone and at least one layer of a lubricious coating material selected from the group consisting of PAMAM dendrimers, PAAm-co-PAA, glycosaminoglycanes, fucoidan, poly-aspartic acid, poly-glutamic acid, carboxymethyl cellulose, carboxymethyl dextranes, alginates, pectins, gellan, carboxyalkyl chitins, carboxymethyl chitosans, sulfated polysaccharides, glucoproteins, and aminoalkylated polysaccharides.

2. The ophthalmic device of claim 1, wherein said ophthalmic device is a contact lens.

3. A contact lens of claim 2, wherein said core material is a hydrogel.

4. A contact lens of claim 3, wherein said hydrogel is a siloxane-containing polymer.

5. The ophthalmic device of claim 2, wherein said lubricious coating further comprises at least one layer of a polyionic material which is non-covalently bond to the lubricous material.

6. The ophthalmic device of claim 2, wherein said contact lens has an averaged CoF of about 3.0 or less.

7. The ophthalmic device of claim 2, wherein said contact lens has increased bacterial adhesion resistance.

8. The ophthalmic device of claim 7, wherein said contact lens has increased bacterial adhesion resistance characterized by having a value of Colony Forming Units (CFU/mm²) per the surface area which is at least about one order lower than value of Colony Forming Units (CFU/mm²) per the surface area of an uncoated contact lens, wherein said contact lens having said lubricious coating and the uncoated contact lens are made of same core material.

9. A ophthalmic device, comprising a core material and a lubricious coating, wherein said ophthalmic device having said lubricious coating thereon has an increased hydrophilicity characterized by an averaged contact angle of about 80 degrees or less, wherein said lubricious coating comprises a capping layer of polyvinylpyrrolidone or at least one layer of a lubricious coating material selected from the group consisting of PAMAM dendrimers, PAAm-co-PAA, glycosaminoglycanes, fucoidan, poly-aspartic acid, poly-glutamic acid, carboxymethyl cellulose, carboxymethyl dextranes, alginates, pectins, gellan, carboxyalkyl chitins, carboxymethyl chitosans, sulfated polysaccharides, glucoproteins, and aminoalkylated polysaccharides, and wherein said lubricious coating further comprises at least one layer of a polyionic material which is non-covalently bond to the lubricous material.

10. The ophthalmic device of claim 9, wherein said lubricious coating comprises a plurality of lubricious bilayers each composed of, in no particular order, one layer of the lubricious material and one layer of the polyionic material.

11. The ophthalmic device of claim 10, wherein the number of the plurality of the lubricious bilayers is from 2 to 20.

12. The ophthalmic device of claim 11, wherein the number of the plurality of the lubricious bilayers is from 4 to 10.

13. The ophthalmic device of claim 9, wherein the lubricious coating further comprises a capping layer of polyvinylpyrrolidone.

14. The ophthalmic device of claim 9, wherein said ophthalmic device is a contact lens having an averaged CoF of about 3.0 or less.

15. The ophthalmic device of claim 9, wherein said ophthalmic device is a contact lens having increased bacterial adhesion resistance.

16. The ophthalmic device of claim 14, wherein said contact lens has increased bacterial adhesion resistance characterized by having a value of Colony Forming Units (CFU/mm²) per the surface area which is at least about one order lower than value of Colony Forming Units (CFU/mm²) per the surface area of an uncoated contact lens, wherein said contact lens having said lubricious coating and the uncoated contact lens are made of same core material.

17. A contact lens of claim 9, wherein said core material is a hydrogel.

18. A contact lens of claim 16, wherein said hydrogel is a siloxane-containing polymer.

19. A ophthalmic device, comprising a core material and a lubricious coating, wherein said ophthalmic device having said lubricious coating thereon has an increased hydrophilicity characterized by an averaged contact angle of about 80 degrees or less, and wherein said lubricious coating comprises at least one layer of a lubricious coating material selected from the group consisting of alginates, PAH lactone, hyaluronic acid and salts thereof, PAMAM dendrimers, PAAm-co-PAA, chondroitin sulfate, chitosan, proteoglycans, and mixtures thereof.

20. The ophthalmic device of claim 19, wherein said ophthalmic device is a contact lens.

21. The ophthalmic device of claim 19, wherein said lubricious coating comprises a capping layer of polyvinylpyrrolidone.