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Cyclodextrins in dental products

  • US 6,942,848 B2
  • Filed: 11/21/2003
  • Issued: 09/13/2005
  • Est. Priority Date: 04/24/1996
  • Status: Expired due to Fees
First Claim
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1. A dentrifice in the form of a toothpaste or tooth gel, comprising:

  • a) from about 0.01% to about 10% of a phenolic, by weight of said dentrifice, said phenolic comprising a combination of menthol, eucalyptol, methyl salicylate, and thymol;

    b) from about 0.1% to about 60% of a soluble cyclodextrin, by weight of said dentrifice, said cyclodextrin being capable of solubilizing said phenolic and being selected from the group consisting of hydroxypropyl beta-cyclodextrin, hydroxyethyl beta-cyclodextrin, hydroxypropyl gamma-cyclodextrin, hydroxyethyl gamma-cyclodextrin, alpha-cyclodextrin and methyl beta-cyclodextrin, and mixtures thereof;

    c) from about 0% to about 25% of ethanol, by weight of said dentrifice;

    d) from about 0.5 to about 4% of a nonionic and/or anionic surfactant, by weight of said dentrifice;

    e) up to 60 percent of an orally acceptable dental abrasive, by weight of said dentrifice; and

    f) an orally acceptable carrier;

    said dentrifice being stable and free of precipitants, flocculants or crystals after storage at about 5°

    C. to about 25°

    C. for at least about one week.

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