Cyclodextrins in dental products

• US 6,942,848 B2
• Filed: 11/21/2003
• Issued: 09/13/2005
• Est. Priority Date: 04/24/1996
• Status: Expired due to Fees

• Current Assignee: McNeil-PPC Incorporated (Johnson & Johnson)
• Original Assignee: Warner-Lambert Company LLC (Pfizer Inc.)
• Inventors: Nelson, Dennis George Anthony, Sheehan, Craig Joseph
• Primary Examiner(s): KRASS, FREDERICK F
• Application Number:
  US10/719,555
• Publication Number:
  US 20040076591A1
• Time in Patent Office: 662 Days
• Field of Search: 424/401, 424/49, 424/52, 424/54, 424/55, 424/56, 424/57, 514/58, 514/922, 514/944
• US Class Current: 424/49
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61K 8/738 Cyclodextrins
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Oral rinse and dentifrice compositions, comprising a phenolic selected from the group consisting of menthol, eucalyptol, methyl salicylate, thymol, triclosan, and mixtures thereof; and a cyclodextrin selected from the group consisting of hydroxypropyl β-cyclodextrin, hydroxyethyl β-cyclodextrin, hydroxypropyl γ-cyclodextrin, hydroxyethyl γ-cyclodextrin, α-cyclodextrin, methyl β-cyclodextrin, and mixtures thereof. These compositions are useful in retarding the development of plaque, treating gingivitis, and in treating the presence of micro-organisms in the oral cavity.

Claims

1. A dentrifice in the form of a toothpaste or tooth gel, comprising:

a) from about 0.01% to about 10% of a phenolic, by weight of said dentrifice, said phenolic comprising a combination of menthol, eucalyptol, methyl salicylate, and thymol;

b) from about 0.1% to about 60% of a soluble cyclodextrin, by weight of said dentrifice, said cyclodextrin being capable of solubilizing said phenolic and being selected from the group consisting of hydroxypropyl beta-cyclodextrin, hydroxyethyl beta-cyclodextrin, hydroxypropyl gamma-cyclodextrin, hydroxyethyl gamma-cyclodextrin, alpha-cyclodextrin and methyl beta-cyclodextrin, and mixtures thereof;

c) from about 0% to about 25% of ethanol, by weight of said dentrifice;

d) from about 0.5 to about 4% of a nonionic and/or anionic surfactant, by weight of said dentrifice;

e) up to 60 percent of an orally acceptable dental abrasive, by weight of said dentrifice; and

f) an orally acceptable carrier;

said dentrifice being stable and free of precipitants, flocculants or crystals after storage at about 5°

C. to about 25°

C. for at least about one week.

2. A dentrifice according to claim 1, comprising an orally acceptable fluoride source sufficient to provide from about 250 ppm to about 1500 ppm fluoride.

4. A method for retarding development of plaque on a dental surface in the oral cavity of a mammal in need thereof, comprising administering to said dental surface of said mammal an effective amount of a dentrifice according to claim 1.

5. A method of treating gingivitis in a mammal in need thereof, comprising administering to said mammal an effective amount of a dentrifice according to claim 1.

6. A method of reducing the viable population of microorganisms in the oral cavity of a mammal in need thereof, comprising administering to said mammal an effective amount of a dentrifice according to claim 1.

3. A dentrifice in the form of a toothpaste or tooth gel, comprising:

a) from about 0.01% to about 3% of a phenolic, by weight of said dentrifice, said phenolic comprising a combination of menthol, eucalyptol, methyl salicylate, and thymol;

b) from about 0.1% to about 30% of a soluble cyclodextrin, by weight of said dentrifice, said cyclodextrin being capable of solubilizing said phenolic and being selected from the group consisting of hydroxypropyl beta-cyclodextrin, hydroxyethyl beta-cyclodextrin, hydroxypropyl gamma-cyclodextrin, hydroxyethyl gamma-cyclodextrin, alpha-cyclodextrin and methyl beta-cyclodextrin, and mixtures thereof;

c) from about 0% to about 25% of ethanol, by weight of said dentrifice;

d) from about 0.5 to about 4% of a nonionic and/or anionic surfactant, by weight of said dentrifice;

e) up to 40 percent of an orally acceptable dental abrasive, by weight of said dentrifice;

f) an orally acceptable fluoride ion source sufficient to provide from about 250 ppm to about 1500 ppm fluoride; and

g) an orally acceptable carrier;

said dentrifice being stable and free of precipitants, flocculants or crystals after storage at about 5°

C. to about 25°

C. for at least about one week.