Measurements of optical inhomogeneity and other properties in substances using propagation modes of light

• US 6,943,881 B2
• Filed: 06/03/2004
• Issued: 09/13/2005
• Est. Priority Date: 06/04/2003
• Status: Active Grant

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Tomophase Corporation
• Inventors: Wang, Feiling
• Primary Examiner(s): Lauchman, Layla G.
• Application Number:
  US10/860,094
• Publication Number:
  US 20050018202A1
• Time in Patent Office: 467 Days
• Field of Search: 356/364, 356/365, 356366-369, 356/451, 356/453, 356/454, 356/477, 356/491, 356/484, 356/479, 359/287, 359/285
• US Class Current: 356/369
• CPC Class Codes: A61B 2562/0242 for varying or adjusting the optical path length in the tissue
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: G01B 2290/35 Mechanical variable delay line
• CPC Class Codes: G01B 2290/40 Non-mechanical variable delay line
• CPC Class Codes: G01B 2290/45 Multiple detectors for detecting interferometer signals
• CPC Class Codes: G01B 2290/70 Using polarization in the interferometer
• CPC Class Codes: G01B 9/0201 using temporal phase variation
• CPC Class Codes: G01B 9/02044 Imaging in the frequency domain, e.g. by using a spectrometer
• CPC Class Codes: G01B 9/02057 by using common path configuration, i.e. reference and object path almost entirely overlapping
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01J 3/02 Details
• CPC Class Codes: G01J 3/021 using plane or convex mirrors, parallel phase plates, or particular reflectors
• CPC Class Codes: G01J 3/0218 using optical fibers
• CPC Class Codes: G01J 3/0224 using polarising or depolarising elements
• CPC Class Codes: G01J 3/42 Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry beam switching arrangements G01J3/08
• CPC Class Codes: G01N 2021/4709 : Backscatter
• CPC Class Codes: G01N 2021/4792 : Polarisation of scatter light
• CPC Class Codes: G01N 21/21 : Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 21/27 : using photo-electric detection G01N21/31 takes precedence; circuits for computing concentration logarithmic circuits G06G7/24; photometric circuits in general G01J
• CPC Class Codes: G01N 21/474 : Details of optical heads therefor, e.g. using optical fibres
• CPC Class Codes: G01N 21/4795 : spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 21/49 : within a body or fluid
• CPC Class Codes: G01N 21/55 : Specular reflectivity
• CPC Class Codes: G02B 21/06 : Means for illuminating specimens

Abstract

This application describes designs, implementations, and techniques for controlling propagation mode or modes of light in a common optical path, which may include one or more waveguides, to sense a sample.

Claims

1. A method for optically measuring a sample comprising:

directing one beam of guided light in a first propagation mode to a sample;

directing a first portion of the guided light in the first propagation mode at a location near the sample away from the sample before the first portion reaches the sample while allowing a second portion in the first propagation mode to reach the sample;

controlling a reflection of the second portion from the sample to be in second propagation mode different from the first propagation mode to produce a reflected second portion;

directing both the first portion in the first propagation mode and the reflected second portion in the second propagation mode through a common waveguide into a detection module to extract information from the reflected second portion on the sample;

adjusting a relative phase delay between the reflected first portion and the reflected second portion to a first value to measure a first signal associated with a first layer within the sample;

adjusting the relative phase delay to a second, different value to measure a second signal associated with a second layer within the sample; and

obtaining a ratio between the first and the second signals to extract information about a layer of the sample located between the first and the second layers.

2. The method as in claim 1, further comprising using a tunable optical bandpass filter to select a center wavelength of a spectral range of the guided light to the sample to obtain a spectral response of the layer of the sample located between the first and the second layers in the spectral range.

3. The method as in claim 1, further comprising using the ratio to measure a concentration of glucose in a dermis layer of a skin tissue.

4. A method for optically measuring a sample, comprising:

directing one beam of guided light in a first propagation mode to a sample;

directing a first portion of the guided light in the first propagation mode at a location near the sample away from the sample before the first portion reaches the sample while allowing a second portion in the first propagation mode to reach the sample;

controlling a reflection of the second portion from the sample to be in a second propagation mode different from the first propagation mode to produce a reflected second portion,

directing both the first portion in the first propagation mode and the reflected second portion in the second propagation mode through a common waveguide into a detection module to extract information from the reflected second portion on the sample;

adjusting a relative phase delay between the reflected first portion and the reflected second portion to a value to select a layer from which a reflection component in the reflected second portion substantially matches the reflected first portion in phase,

modulating the relative phase around the value at a modulation frequency to obtain a measurement; and

processing the measurement to obtain information on the layer.

5. The method as in claim 4, further comprising:

using an optical delay device to produce and adjust the relative phase delay; and

using an optical delay modulator to modulate the relative phase.

6. A method for optically measuring a sample, comprising;

directing one beam of guided light in a first propagation mode to a sample;

directing a first portion of the guided light in the first propagation mode at a location near the sample away from the sample before the first portion reaches the sample while allowing a second portion in the first propagation mode to reach the sample.

controlling a reflection of the second portion from the sample to be in a second propagation mode different from the first propagation mode to produce a reflected second portion,

directing both the first portion in the first propagation mode and the reflected second portion in the second propagation mode through a common waveguide into a detection module to extract information from the reflected second portion on the sample; and

adjusting a relative lateral position between the second portion and the sample to direct the second portion to reach different locations on the sample to obtain information at the different locations.

7. The method as in claim 6, wherein the first propagation mode and the second propagation mode are two polarization modes that are orthogonal to each other.

8. The method as in claim 7, wherein the first propagation mode and the second propagation mode are two orthogonal linear polarization modes.

9. The method as in claim 7, further comprising using a polarization rotator to cause the reflected second portion to be in the second propagation mode.

10. The method as in claim 7, further comprising using a Faraday rotator to cause the reflected second portion to be in the second propagation mode.

11. The method as in claim 7, further comprising using a quarter wave plate to cause the reflected second portion to be in the second propagation mode.

12. The method as in claim 6, further comprising using the common waveguide to both direct the guided light to the sample and to guide the reflected first portion and the reflected second portion away from the sample.

13. The method as in claim 12, wherein the waveguide is a polarization maintaining waveguide.

14. The method as in claim 12, wherein the waveguide is a polarization maintaining fiber.

15. The method as in claim 6, further comprising using an input waveguide different from the common waveguide to direct the guided light to the sample.

16. The method as in claim 6, further comprising adjusting a relative phase delay between the reflected first portion and the reflected second portion.

17. The method as in claim 6, further comprising:

mixing energy of the first propagation mode and the second propagation mode in the detection module to produce a first optical signal and a second optical signal; and

detecting the first and second optical signals to extract the information of the sample.

18. The method as in claim 17, further comprising using a difference between the first optical signal and the second optical signal to extract the information of the sample.

19. The method as in claim 18, further comprising:

modulating a relative phase delay between the reflected first portion and the reflected second portion at a modulation frequency; and

using information on amplitudes of the difference at the modulation frequency and a harmonic of the modulation frequency to extract the information of the sample.

20. The method as in claim 17, further comprising:

separating different optical spectral components in the first optical signal;

measuring the different optical spectral components in the first optical signal;

separating different optical spectral components in the second optical signal;

measuring the different optical spectral components in the second optical signal; and

using the measurements to obtain a spectral response of the sample at a spectral component selected from the different optical spectral components.

21. The method as in claim 20, further comprising using an optical grating to separate the different optical spectral components in the first optical signal by optical diffraction.

22. The method as in claim 6, further comprising controlling a spectral property of the guided light to the sample to obtain the information of the sample.

23. The method as in claim 6, further comprising using a tunable optical bandpass filter to select a center wavelength of a spectral range of the guided light to the sample to obtain a spectral response of the sample in the spectral range.

24. A device for optically measuring a sample, comprising:

a waveguide to receive and guide an input beam in a first propagation mode;

a probe head coupled to the waveguide to receive the input beam and to reflect a first portion of the input beam back to the waveguide in the first propagation mode and direct a second portion of the input beam to a sample, the probe head collecting reflection of the second portion from the sample and exporting to the waveguide the reflection as a reflected second portion in a second propagation mode different from the first propagation mode; and

a detection module to receive the reflected first portion and the reflected second portion in the waveguide and to extract information of the sample carried by the reflected second portion.

25. The device as in claim 24, further comprising:

an optical delay device in an optical path of the reflected first and second portions to produce a relative phase delay between the reflected first and second portions; and

an optical delay modulator in the optical path of the reflected first and second portions to modulate the relative phase.

26. The device as in claim 24, further comprising an optical delay modulator in an optical path of the reflected first and second portions to produce a relative phase delay between the reflected first and second portions and to modulate the relative phase.

27. The device as in claim 24, further comprising a variable optical delay unit in an optical path of the reflected first and second portions to produce a variable relative phase delay between the reflected first and second portions, wherein the variable optical delay unit comprises:

a mode splitting unit to separate the reflected first portion in the first propagation mode and the second portion in the second propagation mode into a first optical path and a second optical path, respectively; and

a variable optical delay element in one of the first and the second optical paths to adjust an optical path length.

28. The device as in claim 27, wherein the variable optical delay element comprises:

a beam splitter to receive an input light beam to be delayed and to transmit a portion of the input light beam;

a transparent plate to receive transmitted light from the beam splitter and to rotate to change a path length of the transmitted light; and

a mirror to reflect light transmitted through the transparent plate back to the transparent plate to reach the beam splitter which reflects light from the transparent plate as a delayed output.

29. The device as in claim 27, wherein the variable optical delay element comprises:

an optical circulator to receive an input light beam to be delayed at a first port and to direct the input light beam to a second port,

a transparent plate to receive light from the second port of the optical circulator and to rotate to change a path length of the light transmitting therethrough; and

a mirror to reflect light transmitted through the transparent plate back to the transparent plate to reach the second optical port of the optical circulator which directs light from the second port to a third port as a delayed output.

30. The device as in claim 27, wherein the variable path length element comprises a fiber and a fiber stretcher engaged to the fiber to change a length of the fiber.

31. The device as in claim 27, wherein the variable path length element comprises two optical collimators and a movable retro-reflector in an optical path linking the two optical collimators.

32. The device as in claim 27, wherein the variable path length element comprises two optical collimators, and an optical plate and a reflector in an optical path linking the two optical collimators, wherein the optical plate rotates to change a path length of light.

33. The device as in claim 24, further comprising a variable optical delay unit in an optical path of the reflected first and second portions to produce a variable relative phase delay between the reflected first and second portions, wherein the variable optical delay unit comprises at least one tunable birefringent material and a fixed birefringent material.

34. The device as in claim 33, wherein the tunable birefringent material comprises a liquid crystal.

35. The device as in claim 33, wherein the tunable birefringent material comprises an electro-optic birefringent material.

36. The device as in claim 24, wherein the detection module comprises an optical detector.

37. The device as in claim 36, wherein the detection module further comprises an optical polarizer to receive and mix the reflected first and second portions to produce an optical output to the optical detector.

38. The device as in claim 37, further comprising an electronic unit to process output from the optical detector and process the output to extract the information of the sample.

39. The device as in claim 24, wherein the detection module comprises:

an optical polarizing beam splitter to receive and mix the reflected first and second portions that are respectively in the first and the second propagation modes to produce a first optical signal and a second optical signal;

a first optical detector to receive the first optical signal;

a second optical detector to receive the second optical signal; and

an electronic unit to receive and process outputs from the first and the second optical detectors to extract the information of the sample.

40. The device as in claim 39, wherein the first and second optical detectors are first and second detector arrays, respectively, the device further comprising:

a first grating to receive and diffract the first optical signal;

a first lens to focus different diffraction components in the first optical signal to different locations on the first detector array;

a second grating to receive and diffract the second optical signal; and

a second lens to focus different diffraction components in the second optical signal to different locations on the second detector array.

41. The device as in claim 24, wherein the probe head comprises a partial mode converter which sets the reflection from the sample in the second propagation mode.

42. The device as in claim 24, wherein the probe head comprises:

a partial reflector to reflect the reflected first portion of the input beam and to transmits the second portion of the input beam to the sample; and

a polarization rotator located between the partial reflector and the sample to change a polarization of the reflected second portion in controlling the reflected second portion to be in the second propagation mode.

43. The device as in claim 24, wherein the probe head comprises:

a partial reflector to reflects the reflected first portion of the input beam and to transmits the second portion of the input beam to the sample; and

a Faraday rotator located between the partial reflector and the sample to change a polarization of the reflected second portion in controlling the reflected second portion to be in the second propagation mode.

44. The device as in claim 24, wherein the probe head comprises:

a partial reflector to reflects the reflected first portion of the input beam and to transmit the second portion of the input beam to the sample; and

a quarter wave plate located between the partial reflector and the sample to change a polarization of the reflected second portion in controlling the reflected second portion to be in the second propagation mode.

45. The device as in claim 24, wherein the waveguide is a polarization maintaining waveguide.

46. The device as in claim 24, wherein the waveguide is a polarization maintaining fiber.

47. The device as in claim 24, further comprising:

a light source to produce the input beam;

an input waveguide to receive the input beam from the light source and to guide the input beam in the first propagation mode;

an output waveguide to receive the reflected first and second portions from the waveguide and to direct the reflected first and second portions to the detection module; and

an optical router coupled to the input waveguide, the waveguide, and the output waveguide and operable to direct light coming from the input waveguide to the waveguide and to direct light coming from the waveguide to the output waveguide.

48. The device as in claim 47, wherein the optical router is an optical circulator.

49. The device as in claim 47, wherein the optical router is a polarization preserving optical circulator.

50. The device as in claim 47, wherein the optical router comprises:

an optical circulator;

a first polarizing beam splitter in the waveguide to transmit light in the first propagation mode and to reflect light in the second propagation mode;

a second polarizing beam splitter in the output waveguide to transmit light in the first propagation mode and to reflect light in the second propagation mode; and

a bypass waveguide coupled between the first and the second polarizing beam splitters to direct the reflected second portion reflected by the first polarizing beam splitter to the second polarizing beam splitter which directs the reflected second portion into the output waveguide by reflection.

51. The device as in claim 47, further comprising a tunable optical filter located in one of the input waveguide, the waveguide, and the output waveguide to select a portion of the spectral response of the sample to measure.

52. The device as in claim 24, further comprising a tunable optical filter to filter the input beam to select a portion of the spectral response of the sample to measure.

53. The device as in claim 24, further comprising a tunable optical filter to filter the reflected first and second portions to select a portion of the spectral response of the sample to measure.

54. The device as in claim 24, further comprising a mechanism to change a lateral relative position between the probe head and the sample to direct the second portion to different locations of the sample.

55. An apparatus for optically measuring a sample, comprising:

a) a light source;

b) a waveguide supporting at least first and second independent propagation modes and guiding the light radiation from the light source in the first propagation mode to the vicinity of a sample under examination;

c) a probe head that terminates the waveguide in the vicinity of the sample and reverses the propagation direction of a portion of the first propagation mode in the waveguide while transmitting the remainder of the light radiation to the sample, the probe head operable to convert reflected light from the sample into the second propagation mode;

d) a differential delay modulator that transmits the light in both the first and the second propagation modes from the probe head and the waveguide and varies the relative optical path length between the first and the second propagation modes;

e) a mode combiner to receive light from the differential delay modulator and operable to superpose the first and the second propagation modes by converting a portion of each mode to a pair of new modes;

f) at least one photodetector to receive light in at least one of the two new modes; and

g) an electronic controller in communication with the photodetector and operable to extract information of the sample from the output of the photodetector.

56. The apparatus as in claim 55, wherein the electronic controller is in communication with and operates to control the differential delay modulator.

57. The apparatus as in claim 55, wherein the electronic controller is in communication with and operates to control the probe head.

58. The apparatus as in claim 55, further comprising a tunable optical bandpass filter located to filter either light to the probe head or light from the probe head to select a spectral response of the sample to measure.

59. An apparatus for optically measuring a sample, comprising:

a first waveguide capable of maintaining at least one propagation mode;

a light source that emits radiation to excite the propagation mode in the first waveguide;

a light director that terminates the first waveguide with its first port and passes the light mode entering the first port, at least in part, through a second port and passes the light modes entering the second port, at least in part, through a third port;

a second waveguide that supports at least two independent propagation modes and having a first end coupled to the second port and a second end;

a probe head coupled to the second end of the second waveguide and operable to reverse the propagation direction of the light in part back to the second waveguide and to transmit the remainder to the sample, the probe head further operable to transform the collected light from the sample reflection to an orthogonal mode supported by the second waveguide and direct light in the orthogonal mode into the second waveguide;

a third waveguide supporting at least two independent propagation modes and being connected to the third port of the light director to receive light therefrom;

a differential delay modulator that connects to the third waveguide to receive light from the second waveguide and imposes a variable phase delay and a variable path length on one mode in reference to the other;

a fourth waveguide supporting at least two independent modes and coupled to the differential delay modulator to receive light therefrom; and

a detection subsystem positioned to receive light from the fourth waveguide and to superpose the two propagation modes from the fourth waveguide to form two new modes, mutually orthogonal, the detection subsystem comprising two photo-detectors respectively receiving light in the new modes.

60. The apparatus as in claim 59, wherein the first, second, third and fourth waveguides are polarization-maintaining optical fibers supporting two orthogonal polarization modes.

61. The apparatus as in claim 59, wherein the probe head comprises an uncoated or coated termination of a polarization-maintaining fiber to have a finite reflectance, a lens and a quarter-wave plate or a Faraday rotator arranged in a series.

62. The apparatus as in claim 59, wherein the differential delay modulator comprises at least one segment of a tunable birefringent material and at least one segment of a fixed birefringent material.

63. The apparatus as in claim 62, wherein the tunable birefringent material comprises a liquid crystal material.

64. The apparatus as in claim 62, wherein the tunable birefringent material comprises a lithium niobate crystal.

65. The apparatus as in claim 62, wherein the fixed birefringent material comprises quartz or rutile.

66. The apparatus as in claim 59, wherein the differential delay modulator comprises means for separating received light by modes and directing one mode through a fixed path while directing the other mode through a variable path length device.

67. The apparatus as in claim 66, wherein the variable path length device comprises:

a beam splitter to receive a light beam to be delayed and to transmit a portion of the light beam;

a transparent plate to receive transmitted light from the beam splitter and to rotate to change a path length of the transmitted light; and

a mirror to reflect light transmitted through the transparent plate back to the transparent plate to reach the beam splitter which reflects light coming from the transparent plate as a delayed output.

68. The device as in claim 66, wherein the variable path length device comprises:

an optical circulator to receive an input light beam to be delayed at a first port and to direct the input light beam to a second port,

a transparent plate to receive light from the second port of the optical circulator and to rotate to change a path length of the light transmitting therethrough; and

a mirror to reflect light transmitted through the transparent plate back to the transparent plate to reach the second optical port of the optical circulator which directs light from the second port to a third port as a delayed output.

69. The apparatus as in claim 66, wherein the variable path length device comprises a piezoelectric stretcher of a polarization-maintaining optical fiber.

70. The apparatus as in claim 66, wherein the variable path length device comprises two collimators both facing a mechanically movable retroreflector in such a way that the collimated light from one collimator is collected by the other through a trip to and from the retroreflector.

71. The apparatus as in claim 66, wherein the variable path length device comprises two collimators optically linked through double passing a rotatable optical plate and bouncing off a reflector.

72. The apparatus as in claim 59, wherein the light director is a polarization-preserving circulator that conveys a mode supported by the first waveguide to one of the modes supported by the second waveguide and conveys the independent modes supported by the second waveguide to the corresponding independent modes supported by the third waveguide.

73. The apparatus as in claim 59, wherein the light director comprises:

a) a polarization-maintaining circulator that conveys a polarization mode entering a first port to a second port, causing no change in the state of polarization, and conveys the polarization mode entering the second port to a third port, causing no change in the state of polarization;

b) a first polarizing beam splitter that is connected to the second port of the polarization-maintaining circulator and separates the light into two different paths by state of polarization; and

c) a second polarizing beam splitter that is connected to the third port of the polarization-maintaining circulator and separates the light into two different paths by state of polarization.

74. The apparatus as in claim 59, wherein the light director is a polarization-insensitive beam splitter.

75. The apparatus as in claim 59, wherein the detection subsystem comprises a polarizing beam splitter oriented in such a way that each split radiation is a superposition of the two independent propagation modes in the fourth waveguide and is received by a photo-detector.

76. The apparatus as in claim 59, further comprising a tunable bandpass filter in one of the first, the second, the third, and fourth waveguides to filter light.

77. A device, comprising:

an optical waveguide to guide an optical radiation in a first optical mode;

an optical probe head coupled to the optical waveguide to receive the optical radiation, the optical probe head operable to (1) redirect a portion of the optical radiation back to the optical waveguide while transmitting the remaining radiation to a sample, (2) receive and direct the reflected or backscattered radiation from the sample into the waveguide, and (3) control the reflected or the backscattered light from the sample to be in a second optical mode different from the first optical mode; and

an optical detection module to receive the radiation redirected by the probe head through the waveguide and to convert optical radiation in the first and second optical modes, at least in part, into a common optical mode.

78. The device as in claim 77, wherein the optical waveguide comprises an optical fiber.

79. The device as in claim 77, wherein the optical waveguide comprises a polarization maintaining fiber.

80. The device as in claim 77, further comprising a differential delay device in an optical path between the optical probe head and the optical detection module to modulate the relative optical path length of the two propagation modes.

81. A device for optically measuring a sample, comprising

an input waveguide, which supports first and second different propagation modes, to receive and guide an input beam in the first propagation mode;

an output waveguide, which supports first and second different propagation modes;

a probe head coupled to the input waveguide to receive the input beam and to the output waveguide to export light, the probe head operable to direct a first portion of the input beam in the first propagation mode into the output waveguide and direct a second portion of the input beam to a sample, the probe head collecting reflection of the second portion from the sample and exporting to the output waveguide the reflection as a reflected second portion in the second propagation mode; and

a detection module to receive the reflected first portion and the reflected second portion in the output waveguide and to extract information of the sample carried by the reflected second portion.

82. The device as in claim 81, wherein the input and output waveguides are polarization maintaining fibers.

83. The device as in claim 81, further comprising a tunable optical bandpass filter positioned to filter the light received by the detection module.