Motility analysis within a gastrointestinal tract

• US 6,944,316 B2
• Filed: 06/20/2002
• Issued: 09/13/2005
• Est. Priority Date: 06/20/2001
• Status: Expired due to Term

• Current Assignee: Given Imaging Limited (Medtronic Plc)
• Original Assignee: Given Imaging Limited (Medtronic Plc)
• Inventors: Meron, Gavriel, Glukhovsky, Arkady, Zinati, Ofra
• Primary Examiner(s): Johns, Andrew W.
• Application Number:
  US10/175,148
• Publication Number:
  US 20030077223A1
• Time in Patent Office: 1,181 Days
• Field of Search: 382/107, 382/128, 348/65, 348/77, 348/85, 600/109, 600/117, 600/160, 128/922
• US Class Current: 382/107
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 1/042 characterised by a proximal camera, e.g. a CCD camera

Abstract

A system and method for measuring and analyzing motility within a body lumen such as the gastrointestinal (GI) tract, where an in vivo imaging device such as a capsule captures images and transmits the images to a processor, which calculates the motility of the device based on comparison of the images. Preferably, the processor compares the intensity of pairs of images or of elements of pairs of images, generates a variance for the compared images, and calculates the motility of the imaging device from the variances. The motility data may be presented to a user in various manners; for example, a plot of motility over time may be generated, or indications of low motility may be presented to the user of the system.

Claims

1. A method for measuring and analyzing motility within a body lumen, the method comprising the steps of:

accepting images acquired by a vehicle disposed within said body lumen; and

calculating a motility of the vehicle within said body lumen based on comparison of said accepted images.

2. The method as in claim 1, wherein said vehicle is a capsule.

3. The method as in claim 1, wherein said motility is relative motility.

4. The method as in claim 1, wherein said motility is absolute motility.

5. The method as in claim 1, wherein said comparison is a comparison of image intensity.

6. The method as in claim 1, further comprising the steps of:

comparing two images;

generating a variance for the two images; and

repeating the comparing and variance generating steps for a plurality of image pairs to generate a series of variance values.

7. The method as in claim 1, wherein the step of comparing the images includes, for a pair of images to be compared, at least the steps of:

dividing each image into sections;

comparing corresponding sections of the images to produce a matrix of difference values; and

calculating a variance between the two images, the variance based on a function of the matrix.

8. The method as in claim 1 wherein said vehicle transmits image data from a gastrointestinal tract.

9. The method as in claim 1, comprising displaying an indication of motility.

10. The method as in claim 1, comprising creating a plot which displays motility as a function of time.

11. The method as in claim 10, comprising:

allowing a user to indicate a point on the plot; and

displaying to the user a set of images corresponding to said point on the plot.

12. The method as in claim 1, comprising the step of providing a visual indication of which of the images correspond to a motility which is below a threshold.

13. A system for measuring and analyzing motility within a body lumen, the system comprising:

an image storage memory accepting images acquired by a vehicle disposed within said body lumen;

an image processor calculating a motility of the vehicle within said body lumen based on comparison of properties of said accepted images; and

a display on which a plot of said motility as a function of time is displayed.

14. The system as in claim 13, wherein said vehicle is a swallowable vehicle.

15. The system as in claim 13, wherein said vehicle is a capsule.

16. The system as in claim 13, wherein said motility is relative motility.

17. The system as in claim 13, wherein said motility is absolute motility.

18. The system as in claim 13, wherein said comparison is a comparison of image intensity.

19. The system as in claim 13, comprising a processor performing the steps of:

comparing two images;

generating a variance for the two images; and

repeating the comparing and variance generating steps for a plurality of image pairs to generate a series of variance values.

20. The system as in claim 13, wherein said vehicle includes a transmitter.

21. The system as in claim 13, comprising:

an input device accepting an indication from a user of a point on the plot, wherein in response to said indication a set of images corresponding to said point on the plot is displayed on said display.

22. A system for measuring and analyzing motility within a body lumen, the system comprising:

an image storage means for accepting images acquired by an image capture means disposed within said body lumen;

an image processor means for calculating a motility of the image capture means within said body lumen based on comparison of properties of said accepted images; and

a display on which a plot of said motility as a function of time is displayed.

23. The system as in claim 22, wherein said image capture means is disposed within a swallowable vehicle.

24. The system as in claim 22, wherein said image capture means is disposed within a capsule.

25. The system as in claim 22, wherein said motility is relative motility.

26. The system as in claim 22, wherein said motility is absolute motility.

27. The system as in claim 22, wherein said comparison is a comparison of image intensity.

28. The system as in claim 22, comprising a processing means for:

comparing two images;

generating a variance for the two images; and

repeating, for a plurality of image pairs, comparing and generating a variance, to generate a series of variance values.

29. The system as in claim 22, wherein said image capture means includes a transmitting means.

30. The system as in claim 22, comprising:

an input means accepting an indication from a user of a point on the plot;

wherein in response to said indication a set of images corresponding to said point on the plot is displayed on said display means.

31. A method for measuring and analyzing motility within a body lumen, the method comprising:

accepting images acquired by a vehicle disposed within said body lumen;

comparing two images;

generating a variance for the two images;

repeating the comparing and variance generating steps for a plurality of image pairs to generate a series of variance values;

calculating a motility of said vehicle within said body lumen based on said series of variance values.

32. A method for measuring and analyzing motility within a body lumen, the method comprising:

accepting images acquired by a capsule disposed within said body lumen;

comparing pairs of said images;

calculating a motility of said capsule within said body lumen based on said comparisons; and

creating a plot which displays motility as a function of time.

33. A method for measuring and analyzing motility within a body lumen, the method comprising:

accepting images acquired by a vehicle disposed within said body lumen;

comparing two images;

generating a variance for the two images;

repeating the comparing and variance generating, steps for a plurality of image pairs to generate a series of variance values;

calculating a motility of said vehicle within said body lumen; and

providing an indication of motility.

34. A method for measuring and analyzing motility within a body lumen, the method comprising:

accepting images acquired by a capsule disposed within said body lumen;

comparing a set of images;

generating a variance for the set of images;

repeating the comparing and variance generating steps to generate a series of variance values;

calculating a motility of said capsule within said body lumen; and

providing an indication of motility of the capsule.

35. A method for measuring and analyzing motility within a body lumen, the method comprising:

accepting images acquired by a capsule disposed within said body lumen; and

calculating a motility of the capsule within said body lumen based on comparison of said accepted images.

36. A method for determining at least one condition in a GI tract comprising the steps of:

calculating a motility of a device within the GI tract;

creating a spectral analysis of said motility;

examining the spectral analysis for at least one parameter;

comparing said parameter to a reference; and

determining a condition, if any, in the GI tract based on the comparison.

37. The method according to claim 36 further comprising creating a plot, which displays motility as a function of time.

38. The method according to claim 36 comprising accepting images acquired by the device.

39. The method according to claim 36 wherein calculating the motility includes at least comparing images accepted from the device.

40. The method according to claim 36 wherein calculating the motility includes at least monitoring the intensity of RF signals transmitted from a capsule disposed within said GI tract.

41. The method according to claim 36, wherein said device is a capsule.

42. A system for determining at least one condition in a GI tract the system comprising:

a receiver capable of receiving signals from a device within the GI tract; and

a controller capable of;

calculating a motility of the device;

creating a spectral analysis of said motility;

examining the spectral analysis for at least one parameter;

comparing said parameter to a reference; and

determining a condition, if any, in the GI tract, based on the comparison.

43. The system according to claim 42 wherein the controller is capable of creating a plot which displays motility as a function of time.

44. The system according to claim 42 wherein calculating the motility includes at least comparing images accepted from the device.

45. The system according to claim 42 wherein said device is a capsule.