Neurostimulator involving stimulation strategies and process for using it
First Claim
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1. A method for treating an abnormal neurological condition comprising the steps of:
- determining a treatment regime for applying at least one electrical burst to brain tissue before detecting an electrical activity in the brain tissue, the at least one burst comprising a multiplicity of pulses, said pulses having pulse parameters;
selecting at least one pulse parameter to vary during the burst, prior to application of the burst;
applying to the brain tissue the at least one electrical burst; and
varying the at least one-previously selected pulse parameters during the at least one electrical burst.
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Abstract
This is a neurostimulator that is configured to treat epilepsy and other neurological disorders using certain stimulation strategies, particularly changing various pulse parameters, during the imposition of a burst of those pulses. The invention includes the processes embodying those stimulation strategies.
416 Citations
65 Claims
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1. A method for treating an abnormal neurological condition comprising the steps of:
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determining a treatment regime for applying at least one electrical burst to brain tissue before detecting an electrical activity in the brain tissue, the at least one burst comprising a multiplicity of pulses, said pulses having pulse parameters;
selecting at least one pulse parameter to vary during the burst, prior to application of the burst;
applying to the brain tissue the at least one electrical burst; and
varying the at least one-previously selected pulse parameters during the at least one electrical burst. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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46. A method for treating an abnormal neurological condition comprising the steps of:
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determining a treatment regime for applying electrical bursts to brain tissue before detecting an electrical activity in the brain tissue, the bursts comprising a multiplicity of pulses, said pulses having pulse parameters;
selecting at least one pulse parameter to vary during the bursts, prior to application of the bursts;
applying to the brain tissue, electrical bursts to different electrodes spatially separated in a brain, and said application of electrical burst being in response to a detectable electrical activity; and
varying at least one of the pulse parameters independently during the bursts. - View Dependent Claims (47, 48, 49)
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50. An implantable neurostimulator assembly for treating a disorder in a human brain, comprising in combination:
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a.) at least a first electrical neurostimulator electrode, and b.) at least a first electrical signal source connectable to said at least first electrical neurostimulator electrode, said first electrical signal source configured to initiated at least one stimulation burst to said at least a first electrical neurostimulation electrode before detecting an electrical activity, said at least one burst comprising pulses having pulse parameters, and wherein the first electrical signal source is configured to select at least one pulse parameter to be varied prior to initiation of a pulse and to vary the selected at least one pulse parameter prior to application of the burst. - View Dependent Claims (51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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Specification