Method and apparatus for electrical stimulation

• US 6,944,503 B2
• Filed: 07/12/2002
• Issued: 09/13/2005
• Est. Priority Date: 07/12/2001
• Status: Expired due to Term

• Current Assignee: Atlantic Therapeutics Ltd. (Caldera Medical Incorporated)
• Original Assignee: BMR Research And Development Limited
• Inventors: Minogue, Conor Michael, Crowe, Louis Michael
• Primary Examiner(s): Layno, Carl
• Application Number:
  US10/194,033
• Publication Number:
  US 20030093133A1
• Time in Patent Office: 1,159 Days
• Field of Search: 607/46, 607 48- 49, 607 66- 67, 607/70, 607/118
• US Class Current: 607/66
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/36021 for treatment of pain

Abstract

Pulsed electrical stimulation is applied to selected tissues via electrodes positioned on and/or in the body. Each electrode is connected to an output (108) of the apparatus. Each output (108) is connected between a high side switch (110) and a low side switch (112) of a switching array. Each stimulation pulse is subdivided into a number of time periods. By operation of the switches (110, 112) each electrode can be selected to operate as an anode or a cathode or neither during any given time period. The spatial and/or time summation of the anode-cathode currents is controlled to selectively to stimulate selected regions and/or types of tissues, typically nerve tissues.

Claims

1. Apparatus for applying pulsed electrical stimulation to a human or animal subject, the apparatus comprising a control circuit having a number of output terminals each of which is connectable, in use, to at least one of an array (greater than two) of electrodes placed on and/or in the subject;

the control circuit including means for providing stimulation pulses to two or more of the electrodes simultaneously whereby the pulses are subdivided into a plurality of contiguous time periods, and for each time period, each output terminal may be connected as either anode, cathode or neither to provide discrimination between stimulated and non-stimulated regions of tissue and/or nerve types of the subject by controlling the time-summated current flow applied via each electrode during each pulse.

2. Apparatus according to claim 1 wherein the control circuit is operable such that the current during a single time period is unlikely to stimulate any tissue and/or any nerve type of the subject.

3. Apparatus according to claim 1 wherein the control circuit is operable such that the current during a single time period is unlikely to stimulate tissue in a preselected region and/or nerve type, but the time-summated current over a number of time periods is likely to stimulate another preselected region and/or nerve type.

4. Apparatus according to claim 1 wherein the control circuit is operable such that the current during a single time period is unlikely to stimulate a selected region of tissue and/or a selected nerve type, but the time-summated current over a number of time periods is likely to stimulate said selected region of tissue and/or said selected nerve type.

5. Apparatus according to claim 1 wherein the control circuit is operable to generate a time period electrode pattern which favours the stimulation of a selected region of tissue and/or a selected nerve type.

6. Apparatus according to claim 1 wherein the control circuit is operable such that the user may select a sequence of time period electrode patterns which favours the stimulation of a preselected region and/or nerve type.

7. Apparatus according to claim 1 wherein a train of pulses is generated and the control circuit is operable such that some of the pulses within the train of pulses may have different time period electrode current patterns.

8. Apparatus according to claim 1 wherein the circuit is operable such that the individual time period durations and/or the number of time periods per pulse are variable.

9. Apparatus according to claim 1 wherein there is included means to set the same or different total current in each time period within a pulse.

10. Apparatus according to claim 1 wherein there is included means to set the current level at each output in each time period within a pulse.

11. Apparatus according to claim 1 wherein the control circuit is operable such that the current through each output is a biphasic waveform with net zero direct current component.

12. Apparatus according to claim 1 wherein the control circuit is operable such that the current through a selected output or outputs has a predetermined DC component.

13. Apparatus according to claim 1 wherein the control circuit is operable such that the time period electrode pattern sequence creates a current density waveform in selected tissue which preferentially stimulates selected nerve types with matching temporal stimulation characteristics.

30. Apparatus according to claim 1, including memory means for storing timeslot pattern sequence data.

14. Apparatus for applying electrical stimulation to a human or animal subject, the apparatus comprising a control circuit having a number of outputs each of which is connectable, in use, to a respective one of an array (greater than two) of electrodes placed on and/or in the subject;

the control circuit being arranged to generate stimulation pulses for application via two or more of the electrodes to the subject simultaneously;

the pulses being subdivided into a plurality of contiguous time periods, and the control circuit including means for selectively connecting the outputs for each time period such that each of the electrodes act as anode(s) or cathode(s) or neither to provide discrimination between stimulated and non-stimulated regions of tissue and/or nerve types of the subject by controlling the time-summated current flow applied via each electrode during each pulse.

15. Apparatus according to claim 14, wherein the control circuit is operable such that during at least one time period the pulse is applied simultaneously across a plurality of outputs at one polarity and one other output at the opposite polarity such that a number of electrodes act as anodes and one electrode as a common cathode, or vice versa, whereby the intensity of the current in the region of the electrodes connected to said plurality of outputs is insufficient to stimulate that region whereas the intensity of the current in the region of the electrode connected to said one output is sufficient to stimulate the latter region.

16. Apparatus according to claim 14, wherein the control circuit is operable such that during different time periods the pulse is applied across respective different outputs of one polarity and a single output of opposite polarity such that electrodes connected to said different outputs act as anodes and one electrode connected to said single output acts as a cathode, or vice versa, whereby the duration of the current in the region of the electrodes connected to said different outputs is insufficient to stimulate that region whereas the duration of the current in the region of the electrode connected to said single output is sufficient to stimulate the latter region.

17. Apparatus according to claim 14, in which the pulse is applied across different combinations of outputs in different time periods to preferentially stimulate at least two different regions of the subject in said different time periods.

18. Apparatus according to claim 14, in which the pulse is applied across different combinations of outputs in different time periods to preferentially stimulate at least one region of the subject with different levels of stimulation during said different time periods.

19. Apparatus according to claim 14, in which the control circuit operates such that the total current flowing, in use, across the electrodes is substantially constant over all time periods of a pulse.

20. Apparatus according to claim 14, in which the control circuit operates such that the total current flowing, in use, across the electrodes differs for at least one time period of a pulse.

21. Apparatus according to claim 14, in combination with an array of electrodes connected to said outputs.

22. Apparatus according to claim 21, in which at least one electrode has a different area to the others.

23. Apparatus according to claim 14, in which at least two of the electrodes are intertwined.

24. Apparatus according to claim 14, including memory means for storing timeslot pattern sequence data.

25. A method of applying electrical stimulation to a human or animal subject, comprising placing a plurality of spaced stimulation electrodes on and/or in the subject, each electrode being capable of selectively acting as an anode, a cathode or neither, and applying electrical stimulation pulses to the subject via a plurality of electrodes simultaneously;

the duration of each pulse comprising a plurality of contiguous time periods during each of which none, some or all of the electrodes are selected to act as anode(s) or cathode(s) or neither to provide discrimination between stimulated and non-stimulated regions of tissue and/or nerve types of the subject by controlling the time-summated current flow applied via each electrode during each pulse.

26. A method according to claim 25, wherein during at least one time period the pulse is applied simultaneously across a plurality of electrodes at one polarity and at least one other common electrode of the opposite polarity whereby the intensity of the current in the region of said plurality of electrodes is insufficient or unlikely to stimulate that region whereas the intensity of the current in the region of the common electrode is sufficient to stimulate the latter region.

27. A method according to claim 25, wherein during different time periods the pulse is applied across respective different electrodes of one polarity and a common electrode of opposite polarity, whereby the duration of the current in the region of said different electrodes is insufficient or unlikely to stimulate that region whereas the duration of the current in the region of the common electrode is sufficient to stimulate the latter region.

28. A method according to claim 25, in which the pulse is applied across different combinations of electrodes in different time periods to preferentially stimulate at least two different regions and/or nerve types of the subject in said different time periods.

29. A method according to claim 25, in which the pulse is applied across different combinations of electrodes in different time periods to preferentially stimulate at least one region and/or nerve type of the subject with different levels of stimulation during said different time periods.