Medical materials and porous scaffolds for tissue engineering made from the biodegradable glycolide/ε-caprolactone copolymer

• US 6,946,143 B2
• Filed: 05/13/2002
• Issued: 09/20/2005
• Est. Priority Date: 12/27/2000
• Status: Active Grant

• Current Assignee: Korea Advanced Institute of Science and Technology
• Original Assignee: Korea Advanced Institute of Science and Technology
• Inventors: Kim, Soo-Hyun, Kwon, Il-Keun, Kim, Young-Ha, Choi, Sung-Won, Park, Ki-Dong, Lee, Soo-Hong
• Primary Examiner(s): Saucier, Sandra E.
• Assistant Examiner(s): BARNHART, LORA ELIZABETH
• Application Number:
  US10/144,813
• Publication Number:
  US 20030215483A1
• Time in Patent Office: 1,226 Days
• Field of Search: 424/443, 424/444, 521/82, 521/61
• US Class Current: 424/443
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Disclosed is a biocompatible medical material and porous scaffold for use in tissue engineering, made from a biodegradable glycolide/ε-caprolactone copolymer having a repeat unit of
wherein x and y are integers greater than or equal to 18, the copolymer has an average molecular weight of about 10,000 daltons or more, and the molar ratio of glycolide: ε-caprolactone in the copolymer is about 4.0:6.0 to 6.0:4.0.

Claims

1. A porous scaffold for tissue engineering made from a biodegradable glycolide/ε

-caprolactone copolymer having a repeat unit of;

wherein;

x and y are integers greater than or equal to 18;

the copolymer has an average molecular weight of about 10,000 daltons; and

the molar ratio of glycolide;

ε

-caprolactone in the copolymer is 4.0;

6.0 to 6.0;

4.0.

2. The porous scaffold of claim 1, having a pore size of about 1 to 800 μ

m.

3. The porous scaffold of claim 1, having a porosity of about 50% to 99%.

4. The porous scaffold of claim 1, having a pore size of about 200 to 500 μ

m and porosity of about 93% to 96%.

5. The porous scaffold of claim 1, for use in tissue cell cultures and tissue regeneration.