Vibratory venous and arterial oximetry sensor

• US 6,947,781 B2
• Filed: 12/12/2003
• Issued: 09/20/2005
• Est. Priority Date: 12/13/2002
• Status: Active Grant

• Current Assignee: Massachusetts Institute of Technology, the united states of america as represented by the secretary of the navy
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Shaltis, Phillip, Asada, Haruhiko H.
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): Kremer, Matthew J
• Application Number:
  US10/734,732
• Publication Number:
  US 20040230107A1
• Time in Patent Office: 648 Days
• Field of Search: 600322-323, 600/335, 600309-310
• US Class Current: 600/335
• CPC Class Codes: A61B 5/0051 by applying vibrations
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: G01N 21/1717 with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

A method and an apparatus for distinguishing concentrations of blood constituents among distinct vascular components in situ. The method has steps of inducing periodic vibration, characterized by a frequency, in a limb of a person in such as manner as to selectively excite a resonant response in a specified blood vessel of the person, an artery or a vein, illuminating the limb of the person with a light source, and synchronously detecting a plethysmographic signal for discriminating response attributable to the specified blood vessel.

Claims

1. A method for distinguishing concentrations of blood constituents among distinct vascular components in situ, the method comprising:

a. inducing periodic vibration, characterized by a frequency, in a limb of a person in such a manner as to selectively excite a resonant response in a specified blood vessel of the person;

b. illuminating the limb of the person with a light source;

c. detecting light from the light source that has traversed the specified blood vessel and generating a plethysmographic signal corresponding thereto; and

d. synchronously detecting the plethysmographic signal for a discriminating response attributable to the specified blood vessel.

2. A method in accordance with claim 1, wherein the specified blood vessel is a vein.

3. A method in accordance with claim 1, further including the step of separately monitoring the plethysmographic signal attributable to the specified blood vessel and a plethysmographic signal attributable to a second specified blood vessel.

4. A method in accordance with either of claim 1 or 3, wherein the step of illuminating the limb includes illuminating with two wavelengths of light.

5. A method in accordance with claim 4, further including the step of ratioing light detected at each of the two wavelengths of light in order to derive oxygen saturation of blood in the vein.

6. A method in accordance with claim 1, wherein the step of inducing vibration in the limb includes modulating air pressure applied to at least one inflatable pad enveloping the limb at least in part.

7. An apparatus for inducing a plethysmographic response due to blood in a specified blood vessel of a person, the apparatus comprising:

a. a vibrator for inducing periodic vibration, characterized by a frequency, in a limb of a person in such a manner a to selectively excite a resonant response in the specified blood vessel of the person;

b. a light source for illuminating the limb of the person;

c. a detector for detecting light from the light source that has traversed the specified blood vessel and for generating a plethysmographic signal corresponding thereto; and

d. a signal processor for synchronously detecting the plethysmographic signal and for a discriminating response attributable to the specified blood vessel.

8. An apparatus in accordance with claim 7, wherein the vibrator is a mechanical perturber.

9. An apparatus in accordance with claim 7, wherein the vibrator is a fluidic perturber.