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Neurocognitive function EEG measurement method and system

  • US 6,947,790 B2
  • Filed: 04/15/2002
  • Issued: 09/20/2005
  • Est. Priority Date: 06/26/2000
  • Status: Expired due to Fees
First Claim
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1. The method of measuring changes in a human subject'"'"'s fundamental cognitive brain functions, the changes, for example, being due to disease, injury, remedial treatment, the utilization of medicines and normal variation within and between days and over a period of time, including the steps of:

  • (a) presenting an attention-damanding task to the subject, which engages one or more of the subject'"'"'s fundamental cognitive functions, and, simultaneously;

    (b) at least once, measuring the subject'"'"'s behavioral responses to the task, and neuroelectric activity at the subject'"'"'s scalp using a set of electroencephalograph (EEG) electrodes and amplifier and analog/digital converters, to provide a set of baseline digital data representing the subject'"'"'s baseline state behavioral responses and neuroelectric activity response to the task;

    (c) at least once again, measuring the subject'"'"'s behavioral responses to the task, and neuroelectric activity at the subject'"'"'s scalp using a set of electroencephalograph (EEG) electrodes and amplifier and analog/digital converters, to provide a set of possibly altered state digital data representing the subject'"'"'s possibly altered state behavioral responses and neuroelectric activity in response to the task;

    (d) in a computer system, comparing the subject'"'"'s baseline state and possibly altered state digital data using a mathematical function derived from behavioral responses and EEG derived neuroelectric activity responses of a reference group of subjects performing the same task recorded in their baseline and altered state conditions, the comparison using a multivariate statistical method combining measures of task performance with brain function measures in a single comparison, and (e) deriving one or more scores for the subject based on the comparison described in (d) and determining the significance of those scores.

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