Therapeutic device for the selective cytoreduction treatment of an obstruction in a natural lumen or passage of the human or animal body
First Claim
1. A therapeutic device intended for substantially fully intracorporeal insertion for treatment of an obstruction in the prostatic portion of a male urethra, comprising:
- a non-biodegradable element that is designed to be placed and retained in a prostatic portion of the male urethra to maintain a channel, said element being sufficiently flexible to conform to the urethra, but sufficiently rigid to maintain the channel for urine flow in the prostatic portion, the channel providing for passage of urine from upstream of the obstruction to downstream of the obstruction; and
a cytoreductive agent that causes reduction of the obstruction, said cytoreductive agent being positioned along said element, so as to treat the obstruction of the prostatic portion of the male urethra when said element is retained in the prostatic portion of the male urethra, wherein said element comprises a bottom end and a top end, and wherein said cytoreductive agent is positioned between said bottom end and said top end of said element, wherein said top end of said element is blind, and includes at least one perforation in order to ensure the passage of urine, and wherein said device further comprises a withdrawal thread and is non-traumatically removable from the male urethra by said withdrawal thread following treatment of the obstruction.
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Accused Products
Abstract
Therapeutic device intended for the selective cytoreductive treatment of an obstruction in a natural lumen or passage of the human or animal body, the lumen being obstructed by the effect of a local cell proliferation, the device including a tubular element, in particular of cylindrical shape, intended to be placed in the natural lumen and sufficiently flexible to conform to the natural lumen, but sufficiently rigid to maintain an artificial channel in the lumen. The tubular element supports lengthwise a medicinal sleeve which is intended to come into line with, and into contact with, the obstruction once the natural lumen has been intubated, and is designed to deliver locally, at least in its outer surface portion, at least one therapeutic agent which is cytoreductive, in particular cytotoxic, through contact with the cells under whose effect the lumen is obstructed.
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Citations
24 Claims
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1. A therapeutic device intended for substantially fully intracorporeal insertion for treatment of an obstruction in the prostatic portion of a male urethra, comprising:
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a non-biodegradable element that is designed to be placed and retained in a prostatic portion of the male urethra to maintain a channel, said element being sufficiently flexible to conform to the urethra, but sufficiently rigid to maintain the channel for urine flow in the prostatic portion, the channel providing for passage of urine from upstream of the obstruction to downstream of the obstruction; and
a cytoreductive agent that causes reduction of the obstruction, said cytoreductive agent being positioned along said element, so as to treat the obstruction of the prostatic portion of the male urethra when said element is retained in the prostatic portion of the male urethra, wherein said element comprises a bottom end and a top end, and wherein said cytoreductive agent is positioned between said bottom end and said top end of said element, wherein said top end of said element is blind, and includes at least one perforation in order to ensure the passage of urine, and wherein said device further comprises a withdrawal thread and is non-traumatically removable from the male urethra by said withdrawal thread following treatment of the obstruction.
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2. A therapeutic device intended for substantially fully intracorporeal insertion for treatment of an obstruction in a natural lumen through which a fluid naturally flows, comprising:
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a non-biodegradable element that is designed to be placed and retained in the natural lumen to maintain a channel, said element being sufficiently flexible to conform to the natural lumen, but sufficiently rigid to maintain the channel for flow of the fluid in the lumen, the channel providing for passage of the fluid from upstream of the obstruction to downstream of the obstruction with respect to natural fluid flow; and
a cytoreductive agent that causes reduction of the obstruction, said cytoreductive agent being positioned along said element, so as to treat the obstruction of the natural lumen when said element is retained in the natural lumen, wherein said element comprises a bottom end and a top end, and wherein said cytoreductive agent is positioned between said bottom end and said top end of said element, wherein said top end of said element is blind, and includes at least one perforation in order to ensure the passage of the fluid, and wherein said device further comprises a withdrawal thread and is non-traumatically removable from the natural lumen by said withdrawal thread following the obstruction.
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3. A therapeutic device intended for substantially fully intracorporeal insertion for treatment of an obstruction in a natural lumen through which a fluid naturally flows, comprising:
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a non-biodegradable element that is designed to be placed and retained in the natural lumen to maintain a channel, said element being sufficiently flexible to conform to the natural lumen, but sufficiently rigid to maintain the channel for flow of the fluid in the lumen, the channel providing for passage of the fluid from upstream of the obstruction to downstream of the obstruction with respect to natural fluid flow;
a cytoreductive agent that causes reduction of the obstruction, said cytoreductive agent being positioned along said element, so as to treat the obstruction of the natural lumen when said element is retained in the natural lumen; and
an other element attached to said non-biodegradable element by a flexible connection, wherein said device further comprises a withdrawal thread and is non-traumatically removable from the natural lumen by said withdrawal thread following treatment of the obstruction. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 24)
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17. A therapeutic device intended for being substantially fully located in a natural lumen through which a fluid naturally flows, said fluid flow being controlled by a sphincter through said lumen, said device comprising:
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a non-biodegradable tubular bio-active element that is designed to be placed in at least an obstructed part of said natural lumen, upstream of said sphincter, said element having a substantially continuous wall and external surface and being sufficiently flexible to conform to said lumen, but sufficiently rigid to maintain a channel for flow of the fluid in the lumen, said wall being fluid-tight with respect to said natural fluid flow, and said channel providing for passage of the fluid flow from upstream of the obstruction to downstream of the obstruction with respect to said natural fluid flow;
said bio-active element being retained in the downstream direction by said sphincter, and in the upstream direction by retaining means linked to said element and to be placed in said lumen downstream of said sphincter, wherein said retaining means is not therapeutically active;
said bio-active element comprising a therapeutic agent that causes reduction of the obstruction supported by and arranged around and along said element to be delivered by contact between said external surface and said obstruction; and
said device being arranged to be inserted into and removed from said lumen in a substantially non-traumatic manner. - View Dependent Claims (18, 19, 20, 22, 23)
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21. A therapeutic device intended for being substantially fully located in a natural lumen through which a fluid naturally flows, said fluid flow being controlled by a sphincter through said lumen, said device comprising:
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a non-biodegradable tubular element that is designed to be placed in at least an obstructed part of said natural lumen, upstream of said sphincter, said clement having a substantially continuous wall and external surface and being sufficiently flexible to conform to said lumen, but sufficiently rigid to maintain a channel for flow of the fluid in the lumen, said channel providing for passage of the fluid flow from upstream of the obstruction to downstream of the obstruction with respect to said natural fluid flow;
said element being retained in the downstream direction by said sphincter, and in the upstream direction by retaining means linked to said element and to be placed in said lumen downstream of said sphincter;
said element comprising a therapeutic agent that causes reduction of the obstruction supported by and arranged around and along said element to be delivered by contact between said external surface and said obstruction; and
said device being arranged to be inserted into and removed from said lumen in a substantially non-traumatic manner, said device comprising a withdrawal thread at its downstream end, arranged for the non-traumatic removal of said device.
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Specification