Vascular inducing implants

• US 6,949,117 B2
• Filed: 01/29/2004
• Issued: 09/27/2005
• Est. Priority Date: 09/30/1998
• Status: Expired due to Fees

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Choh, Richard T., Weiser, Michael F., Gambale, Richard A., Forcucci, Stephen J., Forde, Sean
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US10/767,550
• Publication Number:
  US 20040186557A1
• Time in Patent Office: 607 Days
• Field of Search: 604/506, 604/508, 604/510, 604/57, 604/59, 604/60, 604/104, 604/105, 623/1.11, 623/1.12, 606/107, 606/108, 606/194, 607/119, 607/120, 607/122, 607/126, 607/127, 607/128
• US Class Current: 623/1.12
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61F 2/94 Stents retaining their form, i.e. not being deformable, after placement in the predetermined place
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2230/0091 helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

Claims

1. A delivery device for placing an implant in the myocardium of a patient comprising:

a steerable delivery catheter having at least one lumen and a defined length;

an elongate shaft slidable through the lumen of the delivery catheter having a proximal end, a sharpened distal end capable of piercing tissue and a length greater than the length of the delivery catheter;

means at the distal end of the shaft for releasably retaining the implant in a low profile first configuration and configured to release the implant to a large profile second configuration.

2. A method of percutaneously delivering an implant to myocardial tissue comprising:

providing an implant having a low profile first configuration and a large profile second configuration;

providing a delivery catheter having proximal and distal ends and at least one lumen defined between the ends;

providing an elongate shaft slidable through the lumen of the delivery catheter, having a sharp distal end and means for releasably retaining the implant in its first configuration at the distal end of the shaft;

inserting the delivery catheter in the patient and navigating it through the patient'"'"'s vessels to the left ventricle and positioning the distal end adjacent myocardial tissue;

advancing the shaft, with the implant retained on the distal end, through the lumen of the delivery catheter so that so that the sharp distal end of the shaft and implant protrude from the distal end of the catheter and penetrate the myocardium;

positioning the implant to the desired depth in the myocardium;

releasing the implant from the distal end of the shaft so that it expands to its second configuration in the myocardium;

withdrawing the shaft and delivery catheter from the patient.