Device and method for photoactivation

• US 6,949,753 B2
• Filed: 06/30/2003
• Issued: 09/27/2005
• Est. Priority Date: 03/02/1992
• Status: Expired due to Fees

• Current Assignee: Cerus Corporation
• Original Assignee: Cerus Corporation
• Inventors: Simms, Romilly John, Cimino, George D.
• Primary Examiner(s): Berman, Jack I.
• Application Number:
  US10/611,208
• Publication Number:
  US 20040021089A1
• Time in Patent Office: 820 Days
• Field of Search: 250/455.11, 250/504.R, 250/492.1, 604/6.08
• US Class Current: 250/455.11
• CPC Class Codes: A01N 1/0263 Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
• CPC Class Codes: A01N 1/0294 Electromagnetic, i.e. using electromagnetic radiation or electromagnetic fields
• CPC Class Codes: A61K 31/37 Coumarins, e.g. psoralen
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61K 41/17 by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
• CPC Class Codes: A61L 2/0011 using physical methods
• CPC Class Codes: A61M 1/3616 Batch-type treatment
• CPC Class Codes: A61M 1/3681 by irradiation
• CPC Class Codes: A61M 1/3683 using photoactive agents
• CPC Class Codes: A61M 1/3686 by removing photoactive agents after irradiation
• CPC Class Codes: A61M 1/369 Temperature treatment

Abstract

Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfusion. Inactivation is accomplished using a device having a unique temperature control design.

Claims

1. A method of treating a blood product in a blood bag, comprising:

a) providing i) a blood bag comprising a photoreactive compound and a blood product suspected of containing a pathogen and ii) a blood treatment device comprising a fluorescent bulb and a blood bag support, wherein the end of the fluorescent bulb is blocked from irradiating the blood product;

b) positioning the blood bag on the blood bag support; and

c) irradiating the blood bag with the fluorescent bulb so as to activate the photoreactive compound and inactivate the pathogen.

2. The method of claim 1, wherein the photoreactive compound is a psoralen.

3. The method of claim 2, wherein the blood product comprises plasma.

4. The method of claim 3, wherein the blood product comprises platelets.