Method and device for the iontophoretic delivery of a drug

• US 6,953,446 B2
• Filed: 09/21/2001
• Issued: 10/11/2005
• Est. Priority Date: 09/21/2001
• Status: Expired due to Term

• Current Assignee: Encore Medical Asset Corporation (Enovis Corp.)
• Original Assignee: Iomed, Inc. (Enovis Corp.)
• Inventors: Fischer, Gregory A.
• Primary Examiner(s): Thanh, LoAn H.
• Application Number:
  US09/960,833
• Publication Number:
  US 20030060797A1
• Time in Patent Office: 1,481 Days
• Field of Search: 604/20, 604/93.01, 604500-502, 604/48, 604/244, 604/22, 220/265, 220/260, 401/132
• US Class Current: 604/93.01
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

An iontophoretic drug delivery device storage apparatus and a method of using that device is disclosed. The device comprises a fluid reservoir, an electrode assembly and a tray apparatus. The fluid reservoir is capable of retaining a medicament and has a sealed fluid chamber defined by at least one seal. The seal includes a weaker region and a pinch-like configuration associated with that region such that application of pressure to the fluid reservoir breaks the weaker region of the seal, releasing the retained medicament. The electrode assembly comprises an active electrode, at least two passive electrodes a medicament carrying region, and a moat region around the medicament carrying region so that once fluid is delivered from the fluid reservoir to the electrode assembly the fluid is substantially retained in the medicament carrying means.

Claims

1. A fluid reservoir for use with a drug delivery device, comprising:

a sealed fluid chamber having a top surface and a bottom surface, and a cavity therebetween, the cavity being at least partially defined by at least one seal, wherein the cavity serves to house a fluid therewithin;

means for fracturing at least a portion of the at least one seal; and

means for controllably releasing a liquid out of the cavity, which liquid is positionable within the cavity, wherein the at least one seal comprises a first seal and a second seal, the second seal circumferentially surrounding the cavity, and the first seal concentric to and contained within the second seal, further defining the cavity between the first seal and the second seal.

2. The fluid reservoir of claim 1, wherein the fracturing means is associated with the first seal.

3. The fluid reservoir of claim 1, wherein at least a portion of the top surface is deformable upon exertion of a force.

4. The fluid reservoir of claim 1, wherein the fluid reservoir can be configured in numerous geometrical patterns, one of which is selected from the group consisting of circles, ovals, rectangles, and squares.

5. The fluid reservoir of claim 1, wherein the fluid reservoir is oval in shape, and the first and second seals are concentric with one another.

6. A fluid reservoir for use with a drug delivery device, comprising:

a sealed fluid chamber having a top surface and a bottom surface, and a cavity therebetween, the cavity being at least partially defined by at least one seal, wherein the cavity serves to house a fluid therewithin;

means for fracturing at least a portion of the at least one seal; and

means for controllably releasing a liquid out of the cavity, which liquid is positionable within the cavity;

wherein one of the top and bottom surfaces includes means for directing released fluid to a release reservoir adjacent the fluid reservoir and wherein the flow direction means comprises at least one slit in the release reservoir.

7. The fluid reservoir of claim 6, wherein at least a portion of the top surface is deformable upon exertion of a force.

8. The fluid reservoir of claim 6, wherein the fluid reservoir can be configured in numerous geometrical patterns, one of which is selected from the group consisting of circles, ovals, rectangles, and squares.

9. A method for releasing a fluid from a fluid reservoir, the method comprising the steps of:

depressing at least a portion of a sealed fluid chamber, wherein the fluid chamber includes a cavity at least partially defined by at least one seal, having a fluid therewithin;

fracturing at least a portion of the at least one seal; and

controllably releasing the fluid out of the cavity;

wherein the at least one seal comprises a first seal and a second seal, the second seal circumferentially surrounding the cavity, and the first seal concentric to and contained within the second seal, further defining the cavity between the first and the second seal, the step of fracturing at least one seal comprising the step of fracturing the first seal.

10. The method of claim 9, wherein the fluid chamber additionally comprises a top surface and a bottom surface, the step of depressing comprising deforming at least a portion of the top surface.