Medicine delivery system

• US 6,953,455 B2
• Filed: 07/30/2002
• Issued: 10/11/2005
• Est. Priority Date: 07/30/2002
• Status: Expired due to Fees

• Current Assignee: Hospira Incorporated (Pfizer Inc.)
• Original Assignee: Hospira Incorporated (Pfizer Inc.)
• Inventors: VerLee, Don J, Cromack, Keith, Cho, Steven T., Jara-Almonte, James
• Primary Examiner(s): Lucchesi, Nicholas D.
• Assistant Examiner(s): RODRIGUEZ, CRIS LOIREN
• Application Number:
  US10/207,934
• Publication Number:
  US 20040024382A1
• Time in Patent Office: 1,169 Days
• Field of Search: 6048901-8921, 604/65, 604/66, 604/88, 604/82, 604/244, 604/246, 604/288.01, 604304-307, 604/288.04, 604/93.01, 137/68.11, 137/68.13, 222/541.1, 219/209, 216/2, 216/39, 216/56
• US Class Current: 604/890.1
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/14276 specially adapted for implantation

Abstract

A medicine delivery system (10) implantable into a human or animal body includes a medicine delivery unit (14) and a control unit (12). A membrane (26) seals the delivery opening (22) of a medicine compartment (18) and is pre-stressed by an amount less than the predetermined elastic deformation and rupture point limits of the membrane (26). A release element (28) associated with compartment (18) causes the membrane (26) to be stressed beyond the deformation and rupture point limits in response to a control signal (78). Release element (28) ruptures the membrane (26) along a predetermined rupture pattern to permit a first membrane portion (35), forming a hinged lid, to separate from a second membrane portion (37) along the predetermined rupture pattern while remaining attached to the second membrane portion at a hinge (39).

Claims

1. A medicine delivery system, adapted to be implanted into a human or animal body, comprising:

a control unit adapted to generate a control signal; and

a medicine delivery unit including;

a plurality of compartments, each compartment adapted to contain a predetermined amount of a medicine and having a delivery opening permitting delivery of the medicine;

a membrane adapted to seal the delivery opening of each compartment; and

a plurality of release elements, each release element being associated respectively with the delivery opening of one of the compartments and adapted to rupture the membrane along a predetermined generally U-shaped rupture pattern responsive to the control signal to permit a first membrane portion located inside the predetermined generally U-shaped rupture pattern to separate from a second membrane portion along the predetermined generally U-shaped rupture pattern while remaining pivotally attached to the second membrane portion at a connection area, whereby the rupture of the membrane permits body fluid of the human or animal to mix with the medicine so that the medicine is released in admixture with the body fluids through the delivery opening into the human or animal body.

2. The medicine delivery system according to claim 1, wherein upon rupture of the membrane responsive to the control signal the first membrane portion form a rectangular-shaped lid and the connection area forms a hinge that extends along an attached side edge of the lid and across an open end of the generally U-shaped rupture pattern.

3. The medicine delivery system according to claim 1 further comprising:

a substrate forming a wafer body with a plurality of spaced-apart cavities formed therein, each cavity defining a respective one of the compartments.

4. The medicine delivery system according to claim 3, wherein the membrane is integrally formed with the substrate.

5. The medicine delivery system according to claim 3, wherein the cavities each extend through the substrate to define a charging opening opposite the delivery opening for filling each compartment with the medicine, and wherein a cap is bonded to the substrate for sealing the charging openings.

6. The medicine delivery system according to claim 1, wherein the membrane has a line of weakness formed therein along the predetermined pattern to assist with rupturing the membrane and the release element is adapted to apply thermal shock to rupture the membrane in response to the control signal.

7. The medicine delivery system according to claim 1, wherein the membrane is composed of silicon.

8. The medicine delivery system according to claim 1 wherein the membrane has a predetermined elastic deformation limit and a predetermined rupture point, wherein the membrane is pre-stressed by an amount less than the predetermined elastic deformation limit and the predetermined rupture point, and wherein the release element causes the membrane to be stressed beyond the predetermined elastic deformation limit and the predetermined rupture point to rupture the membrane.

16. The medicine delivery system according to claim 2, wherein the release element is deposited directly on the membrane.

9. A medicine delivery system, adapted to be implanted into a human or animal body, comprising:

a control unit adapted to generate a control signal; and

a medicine delivery unit including;

a substrate having a wafer-shape body;

a compartment formed in the substrate for containing a predetermined amount of a medicine, the compartment having a charging opening permitting the filling of the compartment with medicine and a delivery opening permitting delivery of the medicine from the compartment;

a cap adapted to seal the charging opening of the compartment;

a membrane adapted to seal the delivery opening of the compartment, the membrane having a predetermined elastic deformation limit and a predetermined rupture point, and the membrane being pre-stressed by an amount less than the predetermined elastic deformation limit and the predetermined rupture point; and

a release element associated with the compartment, the release element being adapted to cause the membrane to be stressed beyond the predetermined elastic deformation limit and the predetermined rupture point to rupture the membrane along a predetermined generally U-shaped rupture pattern responsive to the control signal to permit a first membrane portion inside the looping rupture pattern, forming a lid, to separate from a second membrane portion along the predetermined generally U-shaped rupture pattern while remaining pivotally attached to the second membrane portion at a connection area, forming a hinge, whereby the rupture of the membrane permits body fluids of the human or animal to mix with the medicine so that the medicine is released in admixture with the body fluids through the delivery opening into the human or animal body.

10. The medicine delivery system according to claim 9, wherein the membrane is integrally formed with the substrate.

11. The medicine delivery system according to claim 9, wherein the membrane has a line of weakness formed therein along the predetermined rupture pattern to assist with rupturing the membrane.

12. The medicine delivery system according to claim 9, wherein the membrane is composed of silicon.

13. The medicine delivery system according to claim 9, wherein the membrane is pre-stressed under a vacuum pressure.

14. The medicine delivery system according to claim 9, wherein the medicine is a solid.

15. The medicine delivery system according to claim 9, wherein the release element is deposited directly on the membrane and is arranged thereon in generally U-shaped pattern, the hinge extending along an attached side edge of the lid and across an open end of the generally U-shaped pattern.