Device and method for treating ischemic heart disease

• US 6,953,476 B1
• Filed: 03/27/2000
• Issued: 10/11/2005
• Est. Priority Date: 03/27/2000
• Status: Expired due to Term

• Current Assignee: Shockwave Medical, Incorporated (Johnson & Johnson)
• Original Assignee: Neovasc Medical Ltd. (Neovasc Incorporated)
• Inventors: Shalev, Ilan
• Primary Examiner(s): Ho, (Jackie) Tan-Uyen T.
• Application Number:
  US09/534,968
• Time in Patent Office: 2,024 Days
• Field of Search: 623/1.15, 623/1.1, 623 111- 114, 623/1.16, 623/1.18, 623/1.2, 623/1.23, 623 124- 129, 623/1.3, 623/1.34, 623/1.36, 623 15- 153, 606/200
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/01 Filters implantable into blood vessels
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2002/068 Modifying the blood flow model, e.g. by diffuser or deflector
• CPC Class Codes: A61F 2002/91525 within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/9155 Adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2250/0039 differing in diameter

Abstract

A narrowing intraluminal stent is disclosed and comprises a hollow body and a flow passage therethrough, the hollow body designed for intraluminal placement and having at least one portion of an inner cross sectional dimension smaller than the cross sectional dimension of the lumen, so as to artificially narrow a passage through the body lumen. A method of artificially narrowing a passage through a body lumen using the stent is also disclosed.

Claims

1. A flow-reducing intraluminal stent for placement in a coronary sinus of a patient, the stent comprising:

a hollow central portion having first and second ends and defining a flow passage therethrough; and

first and second expandable portions located at the first and second ends of the central portion and having respective outer edges,

wherein the expandable portions are adapted to be expanded within the coronary sinus such that the outer edges widen outward with monotonically increasing diameter to engage a wall of the coronary sinus, so as to firmly affix the stent within the coronary sinus, and

wherein a diameter of the flow passage is substantially fixed at a size that is predetermined prior to implantation by a structure of the central portion, thus reducing a flow of blood through the coronary sinus.

2. A flow-reducing intraluminal stent for placement in a coronary sinus of a patient, the stent comprising:

a hollow central portion having first and second ends and defining a flow passage passing therethrough; and

first and second expandable portions located at the first and second ends of the central portion,

wherein the expandable portions are adapted to be expanded within the coronary sinus so as to firmly affix the stent within the coronary sinus, while a diameter of the flow passage is substantially fixed at a size that is predetermined prior to implantation by a structure of the central portion, thus reducing a flow of blood through the coronary sinus.

3. The flow-reducing intraluminal stent of claim 2, wherein the stent is constructed of a biologically inert material.

4. The flow-reducing intraluminal stent of claim 3, wherein said biologically inert material is selected from the group consisting of stainless steel, nitinol and biocompatible plastic material.

5. The flow-reducing intraluminal stent of claim 2, wherein the stent is coated with a biologically inert material.

6. The flow-reducing intraluminal stent of claim 5, wherein said biologically inert material is selected from the group consisting of stainless steel, nitinol and biocompatible plastic material.

7. The flow-reducing intraluminal stent of claim 2, wherein the stent is configured to decrease a flow of blood through the coronary sinus.

8. The flow-reducing intraluminal stent of claim 7, wherein said decrease in flow of blood through the coronary sinus is sufficient so as to cause coronary angiogenesis.

9. The flow-reducing intraluminal stent of claim 2, wherein said hollow central portion has an inner cross sectional area greater than 7 mm².

10. The flow-reducing intraluminal stent of claim 9, wherein said hollow central portion has an inner cross sectional dimension less than 28 mm².

11. The flow-reducing intraluminal stent of claim 2, wherein said stent has a length greater than 20 mm.

12. The flow-reducing intraluminal stent of claim 11, wherein said stent has a length less than 50 mm.

13. The flow-reducing intraluminal stent of claim 2, wherein a ratio defined by a widest inner cross sectional diameter of said expandable portions, after having been expanded within the coronary sinus, divided by a narrowest inner cross sectional diameter of said hollow central portion is greater than 2.6.

14. The flow-reducing intraluminal stent of claim 13, wherein said ratio is less than 4.3.

15. The flow-reducing intraluminal stent of claim 2, wherein at least one of the expandable portions expands as a result of an occurrence selected from the group consisting of:

(i) application of a force which expands said at least one of the expandable portions; and

(ii) removal of a force which contracts said at least one of the expandable portions.

16. The flow-reducing intraluminal stent of claim 15, wherein said force which expands said at least one of the expandable portions is suppliable by an inflatable balloon of a catheter receivable within said stent.

17. The flow reducing intraluminal stent of claim 2, wherein affixing of the flow reducing intraluminal stent in the coronary sinus occurs as a result of a cause selected from the group consisting of:

(i) a physical contact between a portion of the flow reducing intraluminal stent and an inner surface of the coronary sinus; and

ii) a biological process occurring in cells of an inner surface of the coronary sinus as a result of the presence therein of the flow reducing intraluminal stent.

18. The flow reducing intraluminal stent of claim 2, wherein an integrity of said expandable portions is preserved during a transition from elasticity to plasticity.

19. The flow reducing intraluminal stent of claim 2, wherein said expandable portions comprise an expandable grid.