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Mixed gas microbubble compositions

  • US 6,953,569 B2
  • Filed: 12/19/2001
  • Issued: 10/11/2005
  • Est. Priority Date: 07/30/1993
  • Status: Expired due to Fees
First Claim
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1. An injectable ultrasound contrast agent comprising:

  • (a) a suspension of gas filled microbubbles or microballoons in a physiologically acceptable aqueous carrier comprising surfactants, and additives wherein;

    (b) the gas is a gas mixture of at least two biocompatible gases A and B;

    (c) gas B is present in an amount of between 50%-99% by volume;

    (d) gas B has a water solubility of not more than about 0.5 mM at 25°

    C. and one atmosphere and an average molecular weight at least about 4 times that of gas A; and

    , (e) the balance of the mixture is gas A.

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