Continuous wave optical imaging assuming a scatter-law
First Claim
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1. A method for determining concentration of one or more chromophores in a turbid medium the method comprising:
- i) measuring an attenuation signal using continuous wave (CW) illumination at a predetermined number of wavelengths;
ii) providing a scatter law in which scatter is a function of wavelength;
iii) estimating scatter parameters of said provided scatter law and a concentration for the one or more chromophores, said chromophores having a predetermined relationship between chromophore absorption and concentration as a function of wavelength;
iv) calculating attenuation values at said predetermined wavelengths using the estimated concentrations and scatter parameters;
v) adjusting the concentration for the one or more chromophores and the scatter parameters until the calculated attenuation values and the measured attenuation differ by less than a predetermined value thereby determining said concentration within said medium; and
wherein said predetermined number of wavelengths is sufficient to provide a desired degree of accuracy in said determination of said concentration.
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Abstract
There is provided a method and a system for determining the concentration of chromophores and reconstructing images in turbid media, such as animal tissues, using a continuous wave optical approach. In particular the approach is based on measurements of attenuation signals and the calculation of concentrations of chromophores using a predetermined scatter law. The system comprises a continuous wave photon migration model calculator coupled to an optical source and detector for estimating concentrations of chromophores and scatter parameters used in image reconstruction.
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Citations
29 Claims
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1. A method for determining concentration of one or more chromophores in a turbid medium the method comprising:
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i) measuring an attenuation signal using continuous wave (CW) illumination at a predetermined number of wavelengths;
ii) providing a scatter law in which scatter is a function of wavelength;
iii) estimating scatter parameters of said provided scatter law and a concentration for the one or more chromophores, said chromophores having a predetermined relationship between chromophore absorption and concentration as a function of wavelength;
iv) calculating attenuation values at said predetermined wavelengths using the estimated concentrations and scatter parameters;
v) adjusting the concentration for the one or more chromophores and the scatter parameters until the calculated attenuation values and the measured attenuation differ by less than a predetermined value thereby determining said concentration within said medium; and
wherein said predetermined number of wavelengths is sufficient to provide a desired degree of accuracy in said determination of said concentration. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for optical imaging of a region of interest in a turbid medium, said method comprising:
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i) injecting light at a predetermined number of wavelengths into said tissue at one or more injection ports;
ii) detecting said light at one or more detection ports to obtain a measured attenuation function;
iii) providing a scatter law;
iv) estimating a concentration for one or more chromophores and scatter parameters at a plurality of voxels in said region of interest;
v) calculating attenuation values at said predetermined number of wavelengths using the estimated concentration and scatter parameters and a photon diffusion equation to generate a calculated attenuation function;
vi) adjusting said concentration and said scatter parameters until said calculated attenuation function and said measured attenuation function differ by less than a predetermined value;
vii) generating an image of said tissue using the adjusted concentration for said one or more chromophores at the plurality of voxels in the region of interest; and
wherein a plurality of injection ports/detection ports configurations are used to measure said attenuation function. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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15. A system for continuous wave optical imaging of animal tissue, the system comprising:
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at least one optical source for providing continuous optical energy at a plurality of wavelengths;
at least one optical detector for detecting optical energy and generating continuous data;
a source/object optical coupling for coupling said optical source to a desired position on said tissue;
a detector/object optical coupling for coupling said optical detector to a desired position on said tissue;
an acquisition controller connected to said optical source and said optical detector for collecting said continuous data for a plurality of wavelengths and a plurality of source/detector geometries within a region of interest in said tissue;
a continuous-wave photon migration model calculator for calculating attenuation values;
an estimator using said continuous data and said calculated values to estimate concentration of at least one known chromophore having a known absorption spectrum and wavelength dependent scatter properties;
an optical diffusion parameters calculator using said estimated concentration and scatter properties and chromophore spectral data to calculate absorption and scatter coefficients for said tissue. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification