Metabolic calorimeter employing respiratory gas analysis
First Claim
1. An indirect calorimeter, comprising:
- a respiratory connector configured to be supported in contact with a subject so as to pass inhaled and exhaled gases as said subject breathes;
a hygiene barrier module operatively connected to said respiratory connector, such that said inhaled and exhaled gases pass therethrough said hygiene barrier module for blocking a predetermined pathogen from said exhaled gases;
a flow pathway operatively connected to said hygiene barrier module for receiving and passing said inhaled and exhaled gases, said flow pathway having a first end in fluid communication with said respiratory connector and a second end in fluid communication with a source and sink for respiratory gases, said flow pathway comprising;
(1) a flow tube through which said inhaled and exhaled gases pass, (2) an outer housing surrounding said flow tube, and (3) a chamber disposed between said flow tube and said first end, said chamber being a concentric chamber surrounding one end of said flow tube and being defined between said flow tube and said outer housing;
a flow meter configured to generate electrical signals as a function of an instantaneous flow volume of said inhaled and exhaled gases passing through said flow pathway;
a component gas concentration sensor operable to generate electrical signals as a function of an instantaneous fraction of a predetermined component gas in said exhaled gases passing through said flow pathway; and
a computation unit operable to receive said electrical signals from said flow meter and said concentration sensor and to calculate at least one respiratory parameter for said subject as said subject breathes through said calorimeter.
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Accused Products
Abstract
An indirect calorimeter for measuring the metabolic rate of a subject includes a respiratory connector configured to be supported in contact with the subject so as to pass inhaled and exhaled gases as the subject breathes, a flow pathway, and a hygiene barrier positioned to block a predetermined pathogen from the exhaled gases. The indirect calorimeter also includes a flow pathway having a first end in fluid communication with the respiratory connector and a second end in fluid communication with a source and sink for respiratory gases. The flow pathway includes a flow tube through which the inhaled and exhaled gases pass, an outer housing surrounding the flow tube, and a chamber disposed between the flow tube and the first end. The indirect calorimeter also includes a flow meter configured to generate electrical signals as a function of the instantaneous flow volume of inhaled and exhaled gases passing through the flow pathway, and a component gas concentration sensor operable to generate electrical signals as a function of the instantaneous fraction of a predetermined component gas in the exhaled gases as the gases pass through the flow pathway. The indirect calorimeter further includes a computation unit operable to receive the electrical signals from the flow meter and the concentration sensor and operative to calculate at least one respiratory parameter for the subject as the subject breathes through the calorimeter.
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Citations
62 Claims
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1. An indirect calorimeter, comprising:
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a respiratory connector configured to be supported in contact with a subject so as to pass inhaled and exhaled gases as said subject breathes;
a hygiene barrier module operatively connected to said respiratory connector, such that said inhaled and exhaled gases pass therethrough said hygiene barrier module for blocking a predetermined pathogen from said exhaled gases;
a flow pathway operatively connected to said hygiene barrier module for receiving and passing said inhaled and exhaled gases, said flow pathway having a first end in fluid communication with said respiratory connector and a second end in fluid communication with a source and sink for respiratory gases, said flow pathway comprising;
(1) a flow tube through which said inhaled and exhaled gases pass, (2) an outer housing surrounding said flow tube, and (3) a chamber disposed between said flow tube and said first end, said chamber being a concentric chamber surrounding one end of said flow tube and being defined between said flow tube and said outer housing;
a flow meter configured to generate electrical signals as a function of an instantaneous flow volume of said inhaled and exhaled gases passing through said flow pathway;
a component gas concentration sensor operable to generate electrical signals as a function of an instantaneous fraction of a predetermined component gas in said exhaled gases passing through said flow pathway; and
a computation unit operable to receive said electrical signals from said flow meter and said concentration sensor and to calculate at least one respiratory parameter for said subject as said subject breathes through said calorimeter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An indirect calorimeter, comprising:
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a respiratory connector configured to be supported in contact with a subject so as to pass inhaled and exhaled gases as said subject breathes;
a flow pathway operatively connected to said respiratory connector for receiving and passing said inhaled and exhaled gases, said flow pathway having a first end in fluid communication with said respiratory connector and a second end in fluid communication with a source and sink for respiratory gases, said flow pathway comprising;
(1) a flow tube through which said inhaled and exhaled gases pass, (2) an outer housing surrounding said flow tube, and (3) a chamber disposed between said flow tube and said first end, said chamber being a concentric chamber surrounding one end of said flow tube and being defined between said flow tube and said outer housing;
a hygiene barrier positioned such that said inhaled and exhaled gases pass therethrough said hygiene barrier for blocking a predetermined pathogen from said exhaled gases;
a flow meter configured to generate electrical signals as a function of an instantaneous flow volume of said inhaled and exhaled gases passing through said flow pathway;
a component gas concentration sensor operable to generate electrical signals as a function of an instantaneous fraction of a predetermined component gas in said exhaled gases passing through said flow pathway; and
a computation unit operable to receive said electrical signals from said flow meter and said concentration sensor and to calculate at least one respiratory parameter for said subject as said subject breathes through said calorimeter. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. An indirect calorimeter, comprising:
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a respiratory connector configured to be supported in contact with a subject so as to pass inhaled and exhaled gases as said subject breathes;
a hygiene barrier disposed within said respiratory connector, such that substantially all of said inhaled and exhaled gases pass through said hygiene barrier, and said hygiene barrier operatively passes said inhaled and exhaled gases therethrough while blocking a predetermined pathogen in said exhaled gases;
a flow pathway operable to receive and pass said inhaled and exhaled gases, said flow pathway having a first end in fluid communication with said respiratory connector and a second end in fluid communication with a source and sink for respiratory gases, said flow pathway comprising;
(1) a flow tube through which said inhaled and exhaled gases pass, (2) an outer housing surrounding said flow tube, and (3) a chamber disposed between said flow tube and said first end, said chamber being a concentric chamber surrounding one end of said flow tube and being defined between said flow tube and said outer housing;
a flow meter configured to generate electrical signals as a function of an instantaneous flow volume of said inhaled and exhaled gases passing through said flow pathway;
a component gas concentration sensor operable to generate electrical signals as a function of an instantaneous fraction of a predetermined component gas in said exhaled gases passing through said flow pathway; and
a computation unit operable to receive said electrical signals from said flow meter and said concentration sensor and to calculate at least one respiratory parameter for said subject as said subject breathes through said calorimeter. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 61, 62)
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34. An indirect calorimeter, comprising:
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a flow tube configured to pass respiratory gases of a subject;
a flow meter coupled to said flow tube, said flow meter being configured to generate a first signal associated with said respiratory gases passing through said flow tube;
a component gas concentration sensor coupled to said flow tube, said component gas concentration sensor being configured to generate a second signal associated with said respiratory gases passing through said flow tube; and
a computation unit coupled to said flow meter and said component gas concentration sensor, said computation unit being configured to process said first signal and said second signal to determine a volume of said respiratory gases passing through said flow tube and a concentration of oxygen in said respiratory gases passing through said flow tube, said computation unit being configured to determine an amount of oxygen consumed by said subject based on said volume of said respiratory gases passing through said flow tube and said concentration of oxygen in said respiratory gases passing through said flow tube, said computation unit being configured to determine an amount of carbon dioxide produced by said subject based on said volume of said respiratory gases passing through said flow tube and said concentration of oxygen in said respiratory gases passing through said flow tube, said computation unit being configured to determine a resting metabolic rate for said subject based on said amount of oxygen consumed and said amount of carbon dioxide produced. - View Dependent Claims (35, 36, 37, 38, 39)
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40. An indirect calorimeter, comprising:
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a first sensor configured to generate an output associated with a volume of inhaled gases of a subject and a volume of exhaled gases of said subject;
a second sensor configured to generate an output associated with a fraction of oxygen in said exhaled gases, said second sensor being a fluorescence quench oxygen sensor; and
a processing unit coupled to said first sensor and said second sensor, said processing unit being configured to process said output of said first sensor and said output of said second sensor to determine an amount of carbon dioxide produced by said subject. - View Dependent Claims (41, 42, 43, 44, 45, 46)
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47. An indirect calorimeter, comprising:
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means for generating a first output associated with a volume of respiratory gases of a subject;
means for generating a second output associated with a concentration of oxygen in said respiratory gases; and
means for processing said first output and said second output to determine a resting metabolic rate for said subject, said means for processing said first output and said second output including;
means for determining an amount of oxygen consumed by said subject based on said volume of said respiratory gases and said concentration of oxygen in said respiratory gases; and
means for determining said resting metabolic rate based on said amount of oxygen consumed and an assumed respiratory quotient for said subject. - View Dependent Claims (48, 49, 50)
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51. An indirect calorimeter, comprising:
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a flow tube configured to pass inhaled gases and exhaled gases of a subject;
a flow meter coupled to said flow tube, said flow meter being configured to generate an output associated with a volume of said inhaled gases and a volume of said exhaled gases;
a component gas concentration sensor coupled to said flow tube, said component gas concentration sensor being configured to generate an output associated with a concentration of oxygen in said exhaled gases;
a temperature sensor configured to generate an output associated with ambient temperature;
a pressure sensor configured to generate an output associated with ambient pressure;
a humidity sensor configured to generate an output associated with relative humidity; and
a computation unit coupled to said flow meter, said component gas concentration sensor, said temperature sensor, said pressure sensor, and said humidity sensor said computation unit being configured to process said output of said flow meter and said output of said component gas concentration sensor to determine at least one respiratory parameter for said subject, said computation unit being configured to process said output of said temperature sensor, said output of said pressure sensor, and said output of said humidity sensor to determine said at least one respiratory parameter. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60)
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Specification