Light-controlled electrokinetic assembly of particles near surfaces
First Claim
1. A method of forming an array of particles, said method comprising the following steps:
- providing a first and second electrodes, each having a surface, said surfaces being opposed and positioned to accommodate a liquid medium between said surfaces, said liquid medium having polarizable particles suspended therein; and
generating an electric field at an interface between the second electrode and the liquid medium, wherein the second electrode comprises either;
(a) a light-sensitive electrode capable of controlling the movement of the particles and/or the liquid medium in a direction substantially parallel to the electrode surface when an electric field is generated with n said interface and the light-sensitive electrode is illuminated with a predetermined light pattern, resulting in formation of an ordered array of particles in at least one designated area of the surface of the second electrode, said designated area being defined by the illumination pattern;
or (b) the second electrode is physically or chemically patterned to distribute an electric field in a predetermined manner, when an electric field is generated within said interface, in order to control the movement of the particles and/or the liquid medium in a direction substantially parallel to the electrode surface, said patterning affecting the local distribution of the electric field at the interface, such that the generation of the electric field results in formation of an ordered array of particles in at least one designated area of the surface of the second electrode.
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Accused Products
Abstract
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and far the fabrication of surface-mounted optical components.
86 Citations
16 Claims
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1. A method of forming an array of particles, said method comprising the following steps:
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providing a first and second electrodes, each having a surface, said surfaces being opposed and positioned to accommodate a liquid medium between said surfaces, said liquid medium having polarizable particles suspended therein; and
generating an electric field at an interface between the second electrode and the liquid medium, wherein the second electrode comprises either;
(a) a light-sensitive electrode capable of controlling the movement of the particles and/or the liquid medium in a direction substantially parallel to the electrode surface when an electric field is generated with n said interface and the light-sensitive electrode is illuminated with a predetermined light pattern, resulting in formation of an ordered array of particles in at least one designated area of the surface of the second electrode, said designated area being defined by the illumination pattern;
or(b) the second electrode is physically or chemically patterned to distribute an electric field in a predetermined manner, when an electric field is generated within said interface, in order to control the movement of the particles and/or the liquid medium in a direction substantially parallel to the electrode surface, said patterning affecting the local distribution of the electric field at the interface, such that the generation of the electric field results in formation of an ordered array of particles in at least one designated area of the surface of the second electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification