×

Substituted γ-lactone compounds as NMDA-antagonists

  • US 6,956,055 B2
  • Filed: 01/05/2004
  • Issued: 10/18/2005
  • Est. Priority Date: 07/05/2001
  • Status: Expired due to Fees
First Claim
Patent Images

1. Substituted γ

  • -lactone compounds of the general formula I, embedded imagein whichR1 denotes an optionally at least mono-substituted aryl or heteroaryl residue, an optionally at least mono-substituted aryl or heteroaryl residue attached via a C1-6 alkylene group, an optionally at least mono-substituted, saturated, branched or unbranched aliphatic C1-10 residue, an optionally at least mono-substituted, at least partially unsaturated, branched or unbranched aliphatic C2-10 residue or an optionally at least mono-substituted, saturated or at least mono-unsaturated cycloaliphatic C3-9 residue, R2 denotes an optionally at least mono-substituted, saturated, branched or unbranched aliphatic C1-10 residue or an optionally at least mono-substituted, at least partially unsaturated, branched or unbranched aliphatic C2-10 residue, R3 denotes an optionally at least mono-substituted aryl residue, R4 denotes H, orR3 and R4 together denote an optionally at least mono-substituted, saturated or at least mono-unsaturated aliphatic C3-7 residue, with the proviso that the residue R2 in this case denotes an optionally at least mono-substituted aryl residue, an optionally at least mono-substituted, saturated, branched or unbranched aliphatic C1-10 residue or an optionally at least mono-substituted, at least partially unsaturated, branched or unbranched aliphatic C2-10 residue in the form of the racemates, diastereomers or enantiomers thereof in the form of the base thereof or of a corresponding physiologically acceptable salt, wherein the compounds of the general formula I, in which R1 denotes a 2-, 4-, 6-trichlorophenyl residue, R2 a methyl residue, R3 a phenyl residue and R4 denotes H, are excepted.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×