Rapid measurement of time-averaged blood flow using ungated spiral phase-contrast MRI

• US 6,957,097 B2
• Filed: 04/17/2002
• Issued: 10/18/2005
• Est. Priority Date: 04/17/2002
• Status: Active Grant

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Inventors: Park, Jong B., Nishimura, Dwight B.
• Primary Examiner(s): ROBINSON, DANIEL LEON
• Application Number:
  US10/125,010
• Publication Number:
  US 20030199750A1
• Time in Patent Office: 1,280 Days
• Field of Search: 600/419, 600/410, 600/411, 600/412, 600/413, 600/414, 600/415, 600/416, 600/417, 600/418, 324/386, 324/307, 324/308, 324/309
• US Class Current: 600/419
• CPC Class Codes: A61B 5/0263 using NMR

Abstract

Pulsatile flow is measured using magnetic resonance imaging without cardiac gating using a phase-contrast excitation method to rapidly quantify blood flow and using a spiral k-space trajectory for image data read-out to mitigate deleterious effects of pulsatility. Post-processing of the read-out data provides a cumulative-average velocity plot from which a period of a cardiac cycle is obtained. Time-averaged blood flow rates can be rapidly and robustly measured and is more repeatable than conventional gated techniques.

Claims

1. A method of imaging pulsatile blood flow in a patient using magnetic resonance imaging without cardiac gating comprising the steps of:

a) placing the patient in a static magnetic field,

b) exciting nuclear spins in the presence of a gradient (G_z) for a slice defined by the gradient,

c) applying a phase contrast flow encoding magnetic pulse following step b), d) applying magnetic read-out gradients (G_x, G_y) after step c) whereby spiral k-space type sampling is used during read-out, and

e) acquiring read-out data,

f) repeating steps b)-e) with rotated magnetic readout gradients and without cardiac gating over at least one cardiac cycle, and

g) processing the acquired data to obtain time averaged flow rate information.

2. The method as defined by claim 1 wherein the gradient magnetic field (G_z) in step b) includes a gradient spoiler.

3. The method as defined by claim 2 wherein the readout gradients in step d) rewind the k-space trajectory to k-space origin.

4. The method as defined by claim 3 wherein step g) includes use of a cumulative-average velocity plot from which a period of a cardiac cycle is obtained.

5. The method as defined by claim 4 wherein step c) applies a flow encoding magnetic pulse having a non-zero first moment.

6. The method as defined by claim 5 wherein in step d) k-space is sampled along spiral k-space trajectories.

7. The method as defined by claim 6 wherein the k-space trajectories are interleaved.

8. The method as defined by claim 7 wherein the k-space trajectories have variable density.

9. The method as defined by claim 5 wherein in step d) k-space sampling is along radial lines.

10. The method as defined by claim 5 wherein in step d) k-space sampling is along twisted radial lines.

11. The method as defined by claim 1 wherein step g) includes use of a cumulative-average velocity plot from which a period of cardiac cycle is obtained.

12. The method as defined by claim 1 wherein step c) applies a flow encoding magnetic pulse having a non-zero first moment.

13. The method as defined by claim 1 wherein in step d) k-space sampling is along spiral k-space trajectories.

14. The method as defined by claim 13 wherein the k-space trajectories are interleaved.

15. The method as defined by claim 14 wherein the k-space trajectories have variable density.

16. The method as defined by claim 1 wherein in step d) k-space sampling is along radial lines.

17. The method as defined by claim 1 wherein in step d) k-space sampling is along twisted radial lines.

18. The method as defined by claim 1 wherein step d) applies three readout gradients (G_x, G_y, G_z) and step g) obtains three dimensional time averaged flow information.