Method and apparatus for terahertz imaging

• US 6,957,099 B1
• Filed: 02/23/2000
• Issued: 10/18/2005
• Est. Priority Date: 02/23/1999
• Status: Expired due to Term

• Current Assignee: TeraView Limited
• Original Assignee: TeraView Limited
• Inventors: Arnone, Donald Dominic, Ciesla, Craig Michael
• Primary Examiner(s): ROBINSON, DANIEL LEON
• Application Number:
  US09/914,081
• Time in Patent Office: 2,064 Days
• Field of Search: A61/B00.6/00, H01/L03.1/00, 600/473, 600/407, 600/310, 600/476, 600/322, 600/316, 250/330, 250/338.1, 250/358.1
• US Class Current: 600/473
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0088 for oral or dental tissue
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/4509 Bone density determination
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: G01N 21/3586 by Terahertz time domain spectroscopy [THz-TDS]

Abstract

In an apparatus and method for imaging a sample: a) the sample to be imaged is irradiated with pulsed electro-magnetic radiation with a plurality of frequencies in the range from 50 GHz to 84 THz; b) an area of the sample is subdivided into a two dimensional array of pixels, and radiation from each pixel is detected over a plurality of frequencies; and c) an image is generated from the radiation detected in step (b) preferably using a frequency or a selection of frequencies from the plurality of frequencies in the pulsed electro-magnetic radiation. The method can be used as a medical imaging technique and can be used to image cancer tumours.

Claims

1. A method of imaging a sample, the method comprising:

a) irradiating the sample to be imaged with pulsed electro-magnetic radiation with a plurality of frequencies in the range of 50 GHz to 84 THz;

b) subdividing an area of the sample which is to be imaged into a two dimensional array of pixels, and detecting radiation from each pixel over a plurality of frequencies; and

c) generating an image of the area of the sample from the radiation detected in step (b) using a frequency or a selection of frequencies from the plurality of frequencies in the pulsed electro-magnetic radiation.

2. The method of claim 1, wherein the sample to be imaged in irradiated with pulsed electro-magnetic radiation with a plurality of frequencies in the range from 100 GHz to 20 THz.

3. The process of claim 2, wherein the sample to be imaged in irradiated with pulsed electro-magnetic radiation with a plurality of frequencies in the range from 500 GHz to 10 THz.

4. The method of claim 1, wherein a single image in generated using a selected frequency range.

5. The method of claim 4, wherein the selected frequency range is less than a third of the frequency range of the pulsed electro-magnetic radiation which irradiates the sample.

6. The method of claim 1, wherein a plurality of images in generated from a corresponding plurality of different frequencies.

7. The method of claim 1, wherein, in step (b), the radiation is detected in the time domain and in Fourier transformed to obtain frequency dependent data.

8. The method of claim 1, wherein a fraction of the input pulsed radiation does not irradiate the area of the sample, which is to be imaged, and is detected as a reference signal.

9. The method of claim 1, wherein the method further comprises the step of detecting a reference signal when the area of the sample to be imaged is absent from the path of the pulsed electro-magnetic radiation.

10. The method of claim 8, wherein step (c) comprises the steps of deriving frequency dependent image data from the detected radiation and plotting the frequency dependent image data for each pixel to obtain an image of the sample.

11. The method of claim 8, wherein step (c) comprises the steps of calculating the Power Spectrum for the radiation detected in step (b) and calculating the Power Spectrum of the reference signal.

12. The method of claim 11, wherein the frequency dependent image data is calculated by subtracting the Power Spectrum of the reference signal from the Power Spectrum of the radiation detected in step (b).

13. The method of claim 10, wherein the frequency dependent image data is calculated by dividing the Power Spectrum of the radiation detected in step (b) by the Power Spectrum of the reference signal.

14. The method of claim 10, wherein the frequency dependent image data is calculated by deriving the frequency dependent absorption coefficient from a Fourier transform of the radiation detected in step (b) and a Fourier transform of the reference signal.

15. The method of claim 10, wherein the frequency dependent image data is calculated by deriving the frequency dependent refractive index from a Fourier transform of the radiation detected in step (b) and a Fourier transform of the reference signal.

16. The method of claim 10, wherein the frequency dependent image data is derived for two or more frequencies.

17. The method of claim 16, wherein the frequency dependent image data for the two frequencies is added, subtracted, multiplied and divided for each pixel.

18. The method of claim 10, wherein the frequency dependent image data is obtained for a narrow range of frequencies and the image data is integrated over this narrow range.

19. The method of claim 10, wherein the frequency dependent image data is processed by subdividing the data into a plurality of bands, wherein each band represent a range of magnitudes of the image data fora single frequency or narrow frequency range and each band is assigned a single value or color.

20. The method of claim 19, wherein the bands are not of equal widths in magnitude.

21. The method of claim 19, wherein the image data is derived for more than one frequency and image data for two or more frequencies is combined according to a predetermined rule.

22. The method of claim 21, wherein there are two bands assigned the values ‘

0’ and

‘

1’ and

the predetermined rule is a BOOLEAN algebraic rule.

23. The method of claim 1, the method further comprising the step of displaying a sequence of images generated in step (c) for a plurality of different frequencies.

24. The method of claim 23, wherein the image generated in step (c) is scanable through a continuum of frequencies.

25. The method of claim 23, wherein the image generated in step (c) can be stepped through a plurality of discrete frequencies.