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Inhibition of major groove DNA binding proteins by modified polyamides

  • US 6,958,240 B1
  • Filed: 08/12/1999
  • Issued: 10/25/2005
  • Est. Priority Date: 02/26/1996
  • Status: Expired due to Term
First Claim
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1. A polyamide molecule that specifically binds to base pairs in the minor groove of a DNA molecule, said polyamide molecule comprising:

  • one or more amino acids comprising a moiety selected from the group consisting of N-methylpyrrole, 3-hydroxy-N-methylpyrrole, and N-methylimidazole, wherein one or more of said amino acid(s) are not α

    -amino acids; and

    a positive patch consisting of a rigid group adjacent to a positively charged group, said rigid group comprising a first and a second amino acid;

    said first amino acid being selected from the group consisting of arginine, proline, lysine, and hydroxyproline; and

    said second amino acid being selected from the group consisting of proline, glycine, serine, threonine, leucine, isoleucine, valine, alanine, and hydroxyproline.

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