Method and apparatus for the transdermal administration of a substance
First Claim
1. A delivery device for introducing a substance under pressure into the skin of a patient for delivering the substance to the patient, said device comprising:
- a top wall having at least one opening;
a bottom wall coupled to said top wall and spaced from said top wall to define a reservoir therebetween for containing said substance, said bottom wall having a plurality of openings;
a coupling member attached to said top wall for supplying said substance through said openings in said top wall and into said reservoir;
a check valve disposed at said coupling member to prevent flow from said reservoir through said coupling member; and
a plurality of individual microneedles having a length of about 50 ;
m to about 250 ;
m and integrally formed on said outer surface of said bottom wall and being in communication with said openings in said bottom wall for directing said substance under pressure from said reservoir into the skin of a patient.
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Accused Products
Abstract
A transdermal delivery device includes a plurality of microneedles for injecting a substance such as a pharmaceutical agent into or below the stratum corneum of the skin. The device has housing formed from a top and bottom wall to define a chamber for containing a pharmaceutical agent. An inlet port is provided in the top wall of the housing for supplying the pharmaceutical agent to the chamber and directing the agent to the microneedles. The housing can have a Luer lock type fitting for coupling with a syringe having a Luer lock collar to inject the pharmaceutical agent into the housing. The housing can be divided into a plurality of chambers by an internal wall for supplying different agents simultaneously or sequentially to a patient. The microneedles have a length of about 5–250 microns and generally about 50–100 microns.
151 Citations
10 Claims
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1. A delivery device for introducing a substance under pressure into the skin of a patient for delivering the substance to the patient, said device comprising:
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a top wall having at least one opening; a bottom wall coupled to said top wall and spaced from said top wall to define a reservoir therebetween for containing said substance, said bottom wall having a plurality of openings; a coupling member attached to said top wall for supplying said substance through said openings in said top wall and into said reservoir; a check valve disposed at said coupling member to prevent flow from said reservoir through said coupling member; and a plurality of individual microneedles having a length of about 50 ;
m to about 250 ;
m and integrally formed on said outer surface of said bottom wall and being in communication with said openings in said bottom wall for directing said substance under pressure from said reservoir into the skin of a patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification