Method for the prevention and treatment of skin and nail infections

• US 6,960,201 B2
• Filed: 08/09/2002
• Issued: 11/01/2005
• Est. Priority Date: 02/11/2002
• Status: Expired due to Fees

• Current Assignee: Keraderm Corporation
• Original Assignee: Quantum LLC (Israel Corporation Limited)
• Inventors: Cumbie, William Emmett
• Primary Examiner(s): FARAH, AHMED M
• Application Number:
  US10/215,834
• Publication Number:
  US 20030153962A1
• Time in Patent Office: 1,180 Days
• Field of Search: 606/3, 606/9, 607 88- 91, 128/898
• US Class Current: 606/9
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/1807 using light other than laser radiation
• CPC Class Codes: A61B 2018/2015 Miscellaneous features
• CPC Class Codes: A61L 2/10 Ultraviolet radiation
• CPC Class Codes: A61N 2005/0643 Applicators, probes irradiating specific body areas in close proximity
• CPC Class Codes: A61N 2005/0654 Lamps
• CPC Class Codes: A61N 2005/0661 ultraviolet
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning
• CPC Class Codes: A61N 5/0624 for eliminating microbes, germs, bacteria on or in the body

Abstract

A method of prevention and treatment of microbial infections that occur on, or just below, the skin and nails consisting of the application of electromagnetic radiation to an infected area of skin or nails for a time and at a proximity and intensity sufficient to render the microbes substantially inactivated and incapable of reproducing.

Claims

1. A method for the treatment of nail infections of a user caused by microbes comprising the step of applying electromagnetic radiation in the range of 100 to 280 nm to an infected nail of a user for a time and at a proximity and intensity sufficient to render the microbes substantially incapable of reproducing by at least one of disruption of cellular processes of the microbes or damaging the genetic material of the microbes while insufficient to kill the microbes.

2. The method of claim 1 wherein said nail infections are caused by microbes selected from the group consisting of bacteria, fungi, yeast, molds and viruses.

3. The method of claim 1 wherein said electromagnetic radiation is generated by a mercury lamp or a laser.

4. The method of claim 1 further comprising the step of providing means for preventing said electromagnetic radiation from affecting the user'"'"'s eyes and any area of the user'"'"'s skin and nails not being treated.

5. The method of claim 1 wherein said treatment is supplemented with subsequent oral and topical medications to enhance the effectiveness of said treatment.

6. The method of claim 1, wherein said electromagnetic radiation is generated by an artificial light source providing substantially all of the microbe-affecting radiation in the form of UVC light.

7. The method of claim 1, wherein said electromagnetic radiation is provided for a predetermined time and intensity which is sufficient to inactivate substantially all of the nail-infection-causing microbes.

8. A method for the prevention or treatment of microbial nail infections of a user caused by microbes comprising the step of applying electromagnetic radiation to a nail infected by at least unpigmented microbes that may become infected for a predetermined time and at a proximity and intensity sufficient to render the microbes substantially incapable of reproducing without destroying the microbes, wherein substantially all of the radiation affecting the microbes during the step of applying electromagnetic radiation is provided in the range of 100 nm to 315 nm directly to the microbes to excite and heat the unpigmented microbes without requiring the addition of an external agent such as a pigment, light absorbing material, topical agent or subtopical agent to heat the microbes.

9. The method of claim 8 wherein said microbial infections to be prevented are those caused by microbes selected from the group consisting of bacteria, fungi, yeast, molds and viruses.

10. The method of claim 8 wherein said electromagnetic radiation is UVC light in the range of 100 to 280 nm.

11. The method of claim 8 wherein said electromagnetic radiation is generated by a mercury lamp.

12. The method of claim 8 wherein said electromagnetic radiation is generated by a low pressure mercury lamp emitting at substantially 254 nm.

17. The method of claim 12 further comprising the step of providing means for preventing said electromagnetic radiation from affecting the user'"'"'s eyes and any area of the user'"'"'s skin and nails not being treated.

13. A method for the treatment of a user'"'"'s and nail infections caused by microbes comprising the step of applying a dose of electromagnetic radiation in the range of 100 nm to 315 nm to an infected area of the user'"'"'s skin, whereby radiation in the range of 100 nm to 315 nm directly heats the DNA or RNA of the microbes, and wherein the dose of electromagnetic radiation renders the microbes substantially incapable of reproducing by altering one of the DNA and RNA without killing the microbes.

14. The method of claim 13 wherein said infections are caused by microbes selected from the group consisting of bacteria, fungi, yeast, molds, viruses, and microbes which specifically contribute to acne.

15. The method of claim 13 wherein said electromagnetic radiation is in the range range of 240 nm to 280 nm.

16. The method of claim 13 further including the step of calculating theoretical loss corrections to compensate for electromagnetic radiation energy losses caused during transmission through the infected nail, prior to applying the amount of the dose of electromagnetic radiation to the infected nail.

18. The method of claim 13 wherein said treatment is supplemented with oral and topical medications to enhance the overall effect of said treatment subsequent or prior to the electromagnetic radiation of the user'"'"'s skin.

19. A method for the treatment of nail infections of a user caused by microbes comprising the step of applying a dose of electromagnetic radiation in the range of 100 nm to 280 nm to an infected nail of a user sufficient to render the microbes substantially inactivated by damaging the genetic material of the microbes or by disruption of cellular processes of the microbes without destroying the microbes.

20. The method of claim 19, the dose of electromagnetic radiation is less than half of the radiation required to kill the microbes.

23. The method of claim 20, wherein the reproductive ability of the microbes is damaged by sterilizing the microbes.

21. A method for the treatment of nail infections of a user caused by microbes comprising the step of applying a dose of electromagnetic radiation in a wavelength less than 400 nm capable of directly heating the DNA or RNA of microbes infecting a nail of a user wherein the dose of electromagnetic radiation renders the microbes substantially incapable of reproducing wherein said dose of electromagnetic radiation is less than half of the radiation sufficient to kill the microbes.

22. The method of claim 21, wherein the reproductive ability of the microbes is damaged by disrupting the cellular processes of the microbes.