Branched polyethylene oxide terminated biomedical polymers and their use in biomedical devices

• US 6,961,610 B2
• Filed: 04/25/2002
• Issued: 11/01/2005
• Est. Priority Date: 04/25/2002
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Anderson, James M., Yang, Zhongping, Ebert, Michael J.
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US10/131,440
• Publication Number:
  US 20030204230A1
• Time in Patent Office: 1,286 Days
• Field of Search: 607 1- 5, 607/9, 607/36, 607 39- 58
• US Class Current: 607/2
• CPC Class Codes: A61L 2300/112 Phosphorus-containing compounds, e.g. phosphates, phosphonates
• CPC Class Codes: A61L 2300/204 with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
• CPC Class Codes: A61L 2300/22 Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
• CPC Class Codes: A61L 2300/25 Peptides having up to 20 amino acids in a defined sequence
• CPC Class Codes: A61L 2300/402 Anaestetics, analgesics, e.g. lidocaine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 2300/802 Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

A biomedical polymer has a substantially linear base polymer; and branched polyethylene oxide covalently bonded to the base polymer as surface active end groups. The branched polyethylene oxide has at least two, more particularly at least four, and still more particularly at least six branches. Suitable base polymers include epoxies, polyurethanes, polyurethane copolymers, fluoropolymers, polyolefins and silicone rubbers. Biologically active agents may be attached to the branched polyethylene oxide. Suitable biologically active agents include microbial peptide agents, detergents, non-steroidal anti-inflammatory drugs, cations, amine-containing organosilicones, diphosphonates, fatty acids, fatty acid salts, heparin and glucocorticosteroids. The biological polymer may be used as a casing for a medical unit of an implantable medical device, such as a pacemaker. In this case, the casing at least partially encloses the medical unit.

Claims

1. An implantable medical device, comprising:

a medical unit; and

a casing at least partially enclosing the medical unit, the casing being formed of a base polymer with branched polyethylene oxide attached to the base polymer as surface modifying end groups, the branched polyethylene oxide having at least two branches, wherein two different biologically active agents are attached to the branched polyethylene oxide.

2. An implantable medical device according to claim 1, wherein

the biologically active agents are selected from the group consisting of antimicrobials, antibiotics, microbial peptide agents, biocompatible detergents, non-steroidal anti-inflammatory drugs, cations, amine-containing organosilicones, diphosphonates, fatty acids, fatty acid salts, heparin and glucocorticosteroids.

3. An implantable medical device according to claim 1, wherein the medical unit is a pacemaker lead.

4. An implantable medical device according to claim 1, wherein the base polymer is selected from the group consisting of epoxies, polyurethanes, polyurethane copolymers, fluoropolymers, polyolefins and silicone rubbers.

5. An implantable medical device according to claim 1, wherein the branched polyethylene oxide has at least four branches.

6. An implantable medical device, comprising:

a medical unit; and

a casing at least partially enclosing the medical unit, the casing being formed of a base polymer with branched polyethylene oxide attached to the base polymer as surface modifying end groups, the branched polyethylene oxide having at least two branches, wherein the medical unit contains a shell having an outer surface, and the casing is formed on the outer surface of the shell.

7. An implantable medical device, comprising:

a medical unit; and

a casing at least partially enclosing the medical unit, the casing being formed of a base polymer with branched polyethylene oxide attached to the base polymer as surface modifying end groups, the branched polyethylene oxide having at least two branches, wherein the branched polyethylene oxide has at least six branches.

8. An implantable medical device, comprising:

a medical unit; and

a casing at least partially enclosing the medical unit, the casing being formed of a base polymer with branched polyethylene oxide attached to the base polymer as surface modifying end groups, the branched polyethylene oxide having at least two branches, wherein the branched polyethylene oxide has cross-linked branches.

9. An implantable medical device, comprising:

a medical unit; and

a casing at least partially enclosing the medical unit, the casing being formed of a base polymer with branched polyethylene oxide attached to the base polymer as surface modifying end groups, the branched polyethylene oxide having at least two branches, wherein the branched polyethylene oxide is a heterobifunctional molecule.