Substance delivery device

• US 6,962,579 B2
• Filed: 04/22/2002
• Issued: 11/08/2005
• Est. Priority Date: 03/23/1995
• Status: Expired due to Fees

• Current Assignee: Advanced Animal Technology Limited
• Original Assignee: Advanced Animal Technology Limited
• Inventors: Jellie, Hugh Philip
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): MAYNARD, JENNIFER J
• Application Number:
  US10/131,674
• Publication Number:
  US 20020165488A1
• Time in Patent Office: 1,296 Days
• Field of Search: 604131-136, 604151-153, 604/890.1, 604/891.1, 604 65- 67, 604/19, 604/140, 604/141, 604/207, 604/212, 604/214, 604/216, 604/246, 604104-109, 606/190, 606/191, 606/198
• US Class Current: 604/891.1
• CPC Class Codes: A61D 17/002 for detecting period of heat of animals, i.e. for detecting oestrus for humans A61B10/0012
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

According to one aspect of the present invention there is provided a substance delivery device (1) capable of insertion into a body cavity of an animal, including delivery apparatus (11) capable of actively being controlled to deliver a substance to an outlet, and retention apparatus (2, 3) capable of retaining the substance delivery device within the body cavity of an animal. In one embodiment, a microprocessor (18) can be remotely programmed to enable control over the delivery device after it is placed in the animal. The microprocessor (18) can also communicate with an external device to enable the operation of the delivery device to be determined. The invention may also include sensors to monitor the environment around the delivery device, to determine when a substance sod be delivered into the body.

Claims

1. Substance delivery device for actively delivering at least one substance in either or both solid and fluid form into a body cavity of an animal into which the substance delivery device is inserted, said substance delivery device comprising:

a body having an outlet to the animal body cavity;

at least one reservoir within said body containing a substance;

means for applying pressure to said substance in said at least one reservoir for producing an expulsive force for delivering a predetermined dose of the substance under pressure from said at least one reservoir through said body outlet and into the animal body cavity;

means for actively controlling said means for applying pressure to effect delivery of the predetermined dose at a predetermined time; and

retention apparatus attached to said body for engaging the walls of the animal body cavity for retaining said body in the animal body cavity during delivery of the substance.

2. Substance delivery device as in claim 1 wherein said at least one reservoir is of flexible material and said body has an opening to admit air to apply pressure to a said at least one reservoir to collapse it to aid in forcing the substance therethrough.

3. Substance delivery device as in claim 1 wherein said means for applying pressure to said substance in said at least one reservoir and effecting an expulsive force for delivering a predetermined dose of the substance under pressure from said at least one reservoir through said body outlet and into the animal body cavity comprises a peristaltic pump.

4. Substance delivery device as in claim 1 wherein said means for producing an expulsive force for delivering a predetermined dose of the substance under pressure from said at least one reservoir through said body outlet and into the animal body cavity comprises delivery means which operates to produce pressure on the substance, said delivery means comprising:

a conduit connected between said at least one reservoir and said body outlet; and

a plurality of actuating members to sequentially apply force to a respective portion of said conduit.

5. Substance delivery device as in claim 4 wherein there are a plurality of reservoirs each having an outlet to said conduit which is in common with all of said reservoirs and said actuating members act on said common conduit.

6. Substance delivery device as in claim 4 wherein said actuating members comprise piezoelectric elements.

7. Substance delivery device as in claim 5 wherein each of said plurality of reservoirs is of flexible material and said body has an opening to admit air to apply pressure to each said reservoir to collapse it to aid in forcing the substance therethrough.

8. Substance delivery device as in claim 1 wherein said means for applying pressure to said substance in a said at least one reservoir and effecting an expulsive force for delivering a predetermined dose of the substance from said reservoir through said body outlet and into the animal body cavity is a delivery means which in operation effects pressure on the substance and includes means to actively control the delivery means to effect delivery of the predetermined dose at a predetermined time and which delivery means further comprises:

a conduit between said reservoir and said body outlet; and

a pump in fluid communication with said conduit for withdrawing the substance from a said at least one reservoir.

9. Substance delivery device as in claim 8 wherein a said at least one reservoir is of flexible material and said body has an opening to admit air to apply pressure to a said at least one reservoir to collapse it to aid in forcing the substance therethrough.

10. Substance delivery device as in claim 1 wherein said means for applying pressure to said substance in a said at least one reservoir and effecting an expulsive force for delivering a predetermined dose of the substance from said at least one reservoir through said body outlet and into the animal body cavity is a delivery means which in operation effects pressure on the substance and said delivery means comprises:

means for pressuring said reservoir; and

controllable valve means between an outlet of said reservoir and said body outlet.

11. Substance delivery device as in claim 10 wherein said controllable valve means comprises a magnetically responsive valve.

12. Substance delivery device as in claim 11 wherein said magnetically responsive valve comprises:

a valve housing having a first end with an opening to be in communication with the pressurized substance in a said at least one reservoir and a second end with an opening in communication with said body opening through which the substance is to be delivered into the animal body cavity.

13. Substance delivery device as in claim 12 further comprising a coil of wire around said valve housing to which current is supplied and removed to effect movement of said valve between said first and second ends of said valve housing.

14. Substance delivery device as in claim 13 wherein said valve normally closes said housing second end opening.

15. Substance delivery device as in claim 13 wherein as said valve moves to seal said opening at the first end of said valve housing, the substance is discharged from the said at least one reservoir through the valve first end into a central bore of the valve housing.

16. Substance delivery device as in claim 13 wherein as current is applied to said coil said valve housing first end opening is sealed by said valve and as the current is released said valve moves to seal said valve housing second end opening and during movement to seal said housing second end opening expels the substance out through the opening of said housing second end.

17. Substance delivery device as in claim 10 wherein said means for pressurizing comprises a spring and plunger system.

18. Substance delivery device as in claim 10 wherein said controllable valve means opens and closes in response to the pressure applied to the said at least one reservoir.

19. Substance delivery device as in claim 1 wherein there are a plurality of said reservoirs within said device body and said means for applying pressure to said substance in said plurality of reservoirs and effecting an expulsive force for delivering a predetermined dose of the substance under pressure from a said reservoir through said body outlet and into the animal body cavity selectively operates to expel the substance from any one of said reservoirs through said body outlet and into the animal body cavity.

20. Substance delivery device as in claim 1 wherein said retention apparatus comprises:

a plate to be securely located at least one end of said body;

retention means comprising a plurality of longitudinal arms for extending generally radially from either or both of said plate and said body, the ends of said arms distal from said plate or said body being adapted to contact with an internal surface that defines the animal body cavity;

said arms being flexible to be foldable from a condition for insertion into the animal body cavity to one after insertion of the cavity wherein said arms revert to a retaining condition to maintain continual contact with at least a portion of at least one of said arms lying against the surface of the body cavity for preventing passage of the device through the cavity and/or inadvertent removal.