Dissolution test apparatus

• US 6,962,674 B2
• Filed: 02/28/2001
• Issued: 11/08/2005
• Est. Priority Date: 02/28/2001
• Status: Active Grant

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Varian Incorporated (Agilent Technologies, Inc.)
• Inventors: Dean, Stephen D., Shoytush, Paul, Fernando, C. J. Anthony, Swon, James E.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): Gordon, Brian R.
• Application Number:
  US09/795,819
• Publication Number:
  US 20020119076A1
• Time in Patent Office: 1,714 Days
• Field of Search: 366/91, 366/95, 366/100, 366/201, 366/254, 366/255, 366/165.3, 366/245, 366/249, 366/257, 366/279, 366/292, 366/297, 366/325.1, 422/63, 422/65, 422/66, 422/67, 422/68.1, 422/99, 422/100, 422/225
• US Class Current: 422/68.1
• CPC Class Codes: G01N 13/00 Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects scanning-probe techniques or apparatus G01Q
• CPC Class Codes: G01N 2013/006 Dissolution of tablets or the like
• CPC Class Codes: G01N 33/15 Medicinal preparations ; Physical properties thereof, e.g. dissolubility drug screening with animal cells G01N33/5008

Abstract

A dissolution test apparatus comprises a spindle head assembly interconnected between first and second lateral support members. The lateral support members are translatable along a first axis, and the spindle head assembly is translatable along a second axis, such that the spindle head assembly is movable from a front, operative position at which test procedures are effected, to a rear position at which access to the dissolution test apparatus is enhanced. The spindle head assembly includes a dosage delivery mechanism including an actuatable dosage unit-retaining member. A front portion of the dissolution test apparatus has a tapered width to accommodate a triangular or trapezoidal array of test vessels, resulting in high visibility of the vessels.

Claims

1. A dissolution test apparatus comprising:

(a) a frame assembly for supporting a test vessel and including a front section and a rear section;

(b) a transport assembly including first and second lateral support members, each of the first and second lateral support members including an upper section and a lower section, wherein each of the first and second lateral support members is movably mounted to the frame assembly and movable along a first axis to and from the front and rear sections of the frame assembly; and

(c) a spindle head assembly comprising an operative component for interaction with the test vessel, the spindle head assembly movably connected to each of the first and second lateral support members, wherein the spindle head assembly is movable along a second axis to and from the upper and lower sections of the first and second lateral support members.

2. The apparatus according to claim 1 comprising a vessel plate mounted at the front section of the frame assembly, the vessel plate including a plurality of apertures defining vessel sites.

3. The apparatus according to claim 2 wherein the vessel plate includes first and second lateral edges defining a tapered width of the vessel plate, and the tapered width narrows in a direction from the rear section to the front section.

4. The apparatus according to claim 1 wherein the front section of the frame assembly includes first and second lateral edges defining a tapered width of the front section, and the tapered width narrows in a direction from the rear section to the front section.

5. The apparatus according to claim 1 comprising first and second lateral guide members mounted to the frame assembly and extending generally parallel to the first axis, wherein the transport assembly movably engages the first and second lateral guide members.

6. The apparatus according to claim 1 wherein the transport assembly comprises first and second vertical guide members extending generally parallel to the second axis, and the spindle head assembly is movably connected to the first and second vertical guide members.

7. The apparatus according to claim 2 wherein the apertures of the vessel plate are arranged in a generally triangular array.

8. The apparatus according to claim 3 wherein the apertures of the vessel plate are arranged in a generally triangular array between the first and second lateral edges of the vessel plate.

9. The apparatus according to claim 1 wherein the operative component comprises a shaft for insertion in the test vessel.

10. The apparatus according to claim 1 wherein the operable component comprises a probe mechanism.

11. The apparatus according to claim 1 wherein the operative component comprises a dosage delivery mechanism.

12. The apparatus according to claim 1 wherein the spindle head assembly comprises a spindle head cover movable for enabling access into the spindle head assembly.

13. The apparatus according to claim 11 wherein the dosage delivery mechanism comprises a dosage delivery passage, an actuator, and a dosage retaining element movable by the actuator between a closed state and an open state, and wherein at the closed state the dosage retaining element obstructs the dosage delivery passage, and at the open state the dosage retaining element is disposed in non-obstructive relation to the dosage delivery passage.

14. The apparatus according to claim 1 wherein the operative component comprises a combined probe/dosage delivery mechanism.

15. The apparatus according to claim 14 wherein the combined probe/dosage delivery mechanism comprises:

(a) a body defining a dosage delivery passage;

(b) a dosage retaining element movable between a closed state wherein the dosage retaining unit obstructs the dosage delivery passage and an open state wherein the dosage retaining unit is disposed in non-obstructive relation to the dosage delivery passage;

(c) a probe member bore formed in the body; and

(d) a probe member movably disposed in the probe member bore.

16. The apparatus according to claim 1 wherein:

(a) the spindle head assembly is movable along the first axis between a rear position and an intermediate position, and is movable along the second axis between the intermediate position and an operative position;

(b) at the rear position, the spindle head assembly is disposed above the rear section of the frame assembly in non-obstructive relation to the front section of the frame assembly;

(c) at the intermediate position, the spindle head assembly is disposed above the front section of the frame assembly at a raised elevation; and

(d) at the operative position, the spindle head assembly is disposed above the front section of the frame assembly at a lowered elevation for enabling the operative component to interact with the test vessel.

17. The apparatus according to claim 1 wherein the spindle head assembly comprises a plurality of vessel operation groups movable with the spindle head assembly, each vessel operation group including a shaft, a dosage delivery mechanism and a probe mechanism for interaction with the test vessel.

18. A dissolution test apparatus comprising:

(a) a frame assembly for supporting a test vessel and including a front section and a rear section;

(b) first and second lateral support members movably mounted to the frame assembly for movement between the front and rear sections along a first axis, each of the first and second lateral support members including an upper section and a lower section; and

(c) a spindle head assembly comprising an operative component for interaction with the test vessel, the spindle bead assembly connected to the first and second lateral support members for movement therewith along the first axis, wherein the spindle head assembly is movable along a second axis to and from the upper and lower sections of the first and second lateral support members.

19. The apparatus according to claim 18 comprising an elongate spindle head guide member depending downwardly from the spindle head assembly toward the frame assembly.

20. The apparatus according to claim 18 comprising first and second lateral guide members mounted to the frame assembly and extending generally parallel to the first axis, wherein the first lateral support member movably engages the first lateral guide member and the second lateral support member movably engages the second lateral guide member.

21. The apparatus according to claim 18 comprising first and second vertical guide members respectively mounted to the first and second lateral support members and extending generally parallel to the second axis, wherein the spindle head assembly is movably connected to the first and second vertical guide members.

22. The apparatus according to claim 21 comprising first and second slide blocks respectively movably engaging the first and second vertical guide members, wherein the spindle head assembly is connected to the first and second slide blocks.

23. The apparatus according to claim 18 comprising a motorized lift assembly operatively coupling the spindle head assembly to the first and second lateral support members.

24. The apparatus according to claim 23 wherein the lift assembly comprises first and second gear members, the first and second lateral support members respectively comprise first and second gear meshing components, the first gear member operatively engages the first gear meshing component, and the second gear member operatively engages the second gear meshing component.

25. The apparatus according to claim 23 wherein the lift assembly is supported by the spindle head assembly.

26. The apparatus according to claim 18 wherein:

(a) the spindle head assembly is movable along the first axis between a rear position and an intermediate position, and is movable along the second axis between the intermediate position and an operative position;

(b) at the rear position, the spindle head assembly is disposed above the rear section of the frame assembly in non-obstructive relation to the front section of the frame assembly;

(c) at the intermediate position, the spindle head assembly is disposed above the front section of the frame assembly at a raised elevation; and

(d) at the operative position, the spindle head assembly is disposed above the front section of the frame assembly at a lowered elevation for enabling the operative component to interact with the test vessel.

27. The apparatus according to claim 26 wherein:

(a) the spindle head assembly comprises an elongate spindle head guide member having upper and lower ends and depending downwardly from the spindle head assembly, the upper end of the elongate spindle head guide member supported by the spindle head assembly;

(b) at the rear position, the lower end of the elongate spindle head guide member is spaced above the rear section of the frame assembly;

(c) at the intermediate position, the lower end of the elongate spindle head guide member is spaced above the front section of the frame assembly; and

(d) at the operative position, the lower end of the elongate spindle head guide member extends into the front section.

28. The apparatus according to claim 27 wherein the front section of the frame assembly includes an alignment bore and the elongate spindle head guide member extends into the alignment bore at the operative position of the spindle head assembly.

29. The apparatus according to claim 27 comprising:

(a) a lift rod movably disposed in the elongate spindle head guide member and including an upper end and a lower end; and

(b) a lift rod position sensor operatively aligned with the upper end of the lift rod and adapted to detect upward movement of the lift rod with respect to the elongate spindle head guide member.

30. The apparatus according to claim 19 comprising a lift rod movably disposed in the elongate spindle head guide member.

31. The apparatus according to claim 18 comprising a latch assembly mounted to the frame assembly and including a movable latch head releasably engaging the transport assembly into a locked position.