Use of spatiotemporal response behavior in sensor arrays to detect analytes in fluids
First Claim
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1. A system for identifying an analyte in a fluid, comprising:
- a fluid flow chamber having a first end and a second end;
a sensor array including at least a first sensor and a second sensor in an arrangement in the fluid flow chamber such that at least the first sensor is proximal to the first end of the flow chamber and at least the second sensor is proximal to the second end of the flow chamber thereby having a defined fluid flow path, wherein a fluid moving in the fluid flow chamber contacts the at least two sensors at different times;
a measuring apparatus coupled to the sensor array, the measuring apparatus being configured to detect a response from the first sensor and the second sensor upon exposure of the sensor array to the fluid; and
a computer configured to generate data indicating the analyte in the fluid based on a spatio-temporal difference between the responses for the first and second sensors and identifying the analyte based upon the spatio-temporal difference.
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Abstract
Methods, systems and sensor arrays are provided implementing techniques for detecting an analyte in a fluid. The techniques include providing a sensor array including at least a first sensor and a second sensor in an arrangement having a defined fluid flow path, exposing the sensor array to a fluid including an analyte by introducing the fluid along the fluid flow path, measuring a response for the first sensor and the second sensor, and detecting the presence of the analyte in the fluid based on a spatio-temporal difference between the responses for the first and second sensors.
106 Citations
47 Claims
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1. A system for identifying an analyte in a fluid, comprising:
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a fluid flow chamber having a first end and a second end;
a sensor array including at least a first sensor and a second sensor in an arrangement in the fluid flow chamber such that at least the first sensor is proximal to the first end of the flow chamber and at least the second sensor is proximal to the second end of the flow chamber thereby having a defined fluid flow path, wherein a fluid moving in the fluid flow chamber contacts the at least two sensors at different times;
a measuring apparatus coupled to the sensor array, the measuring apparatus being configured to detect a response from the first sensor and the second sensor upon exposure of the sensor array to the fluid; and
a computer configured to generate data indicating the analyte in the fluid based on a spatio-temporal difference between the responses for the first and second sensors and identifying the analyte based upon the spatio-temporal difference. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A system for detecting an analyte in a fluid, comprising:
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a sensor array including a first sensor and a second sensor;
a fluid flow chamber comprising a fluid inlet proximate to the first sensor of the sensor array, and wherein the second sensor is further distal to the fluid inlet thereby defining a fluid flow pattern such that the first and second sensors are located at different locations in the sensor array relative to the fluid flow pattern, wherein a fluid moving in the defined fluid flow pattern contacts the at least two sensors at different times;
a measuring apparatus connected to the sensor array, the measuring apparatus being configured to detect a response from the first sensor and the second sensor upon exposure of the sensor array to the fluid, the responses for the first and second sensors based on the locations of the sensors relative to the fluid flow pattern; and
a computer configured to generate data indicating the analyte in the fluid based on a spatio-temporal difference between the responses for the first and second sensors and identifying the analyte based upon the spatio-temporal difference. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A system for detecting an analyte in a fluid, comprising:
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a sensor array including a first sensor and a second sensor;
a fluid flow chamber comprising a first end and a second end, whereby the first and second sensors occupy different locations in the sensor array relative to the first end and second end of the fluid flow chamber, wherein a fluid moving in a defined fluid flow path contacts the at least two sensors at different times;
a measuring apparatus connected to the sensor array, the measuring apparatus being configured to detect a response from the first and second sensor upon exposure of the sensor array to the fluid flow, the response differences based on the locations of the sensors in the sensor array relative to the fluid flow; and
a computer configured to generate data indicating the analyte in the fluid based on a spatio-temporal difference between the responses for the first and second sensors and identifying the analyte based upon the spatio-temporal difference. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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Specification