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Decellularized tissue engineered constructs and tissues

  • US 6,962,814 B2
  • Filed: 08/16/2001
  • Issued: 11/08/2005
  • Est. Priority Date: 08/16/2000
  • Status: Expired due to Term
First Claim
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1. A construct for use as a tissue engineering scaffold or for implanting into a subject comprising:

  • a tissue engineered construct comprising a 3-dimensional proteinaceous extracellular matrix that has been subjected to decellularization, wherein the tissue engineered construct was formed by seeding a substrate with cells and maintaining said cells under conditions suitable for growth of the cells, whereby a proteinaceous extracellular matrix surrounding said cells is formed, wherein the substrate comprises a collagen sponge.

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