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Analyte detection system

  • US 6,962,820 B2
  • Filed: 02/12/2004
  • Issued: 11/08/2005
  • Est. Priority Date: 11/14/2001
  • Status: Active Grant
First Claim
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1. A use of a fluorescent label in a particle comprising incorporating one or more fluorescent label into a particle, at least one fluorescent label being a compound of the formula:

  • embedded imagewherein;

    A and B each independently represent ring structures with sufficient carbon atoms to make up a cyanine nuclei;

    X and Y are each independently selected from the group consisting of O, S, NR9, and CR9R10;

    R1 and R2 are each independently selected from the group consisting of H, C1-C20 alkyl, C1-C20 haloalkyl, C1-C20 alkylene, and C1-C20 haloalkylene;

    R3 is selected from the group consisting of H, halogen, OH, OR11, SR11, NR11R12, C1-C6 alkyl, C1-C6 alkylene, C3-C6 cycloalkyl, C3-C6 cycloheteroalkyl, C3-C6 cycloalkylene, C3-C6 cycloheteroalkylene, phenyl, biaryl, heteroaryl, and heterobiaryl, wherein the C1-C6 alkyl, C1-C6 alkylene, C3-C6 cycloalkyl, C3-C6 cycloheteroalkyl, C3-C6 cycloalkylene, C3-C6 cycloheteroalkylene, phenyl, biaryl, heteroaryl and heterobiaryl groups are unsubstituted or substituted with halogen, OH, C1-C4 alkyl, or C1-C4 haloalkyl;

    R8 is selected from the group consisting of C1-C4 alkyl, and C1-C4 haloalkyl;

    R9 and R10 are each independently selected from the group consisting of hydrogen, C1-C4 alkyl, and C1-C4 haloalkyl; and

    R11 and R12 are each independently selected from the group consisting of C1-C6 alkyl, C3-C6 cycloalkyl, phenyl, biaryl, heteroaryl, or heterobiaryl, wherein the C1-C6 alky1, C1-C6 cycloalkyl, phenyl, biaryl, hereroaryl, and heterobiaryl groups are unsubstituted or substituted with halogen, OH, C1-C4 alkyl, or C1-C4 haloalkyl, or when R3 represents NR11R12, R11 and R12 may be taken together to form an optionally substituted C3-C6 aliphatic or C3-C6 aromatic heterocyclic ring.

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