Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors
First Claim
1. A method for monitoring a patient undergoing treatment for cancer, comprising:
- positioning at least one wireless sensor in tissue in a region of interest in the body of a patient being treated for cancer;
administering a therapeutic radiolabeled analyte to the patient;
detecting in vivo from the at least one sensor a signal corresponding to radiation in the region of interest in the patient responsive to the administering step;
relaying the signal to a location external of the patient'"'"'s body; and
monitoring the signal over time to determine the localized response of the patient to the administered analyte to provide patient-specific response data that can be used to develop a patient specific cancer treatment strategy and/or evaluate the clinical efficacy of the treatment in the patient.
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Accused Products
Abstract
Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor'"'"'s condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.
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Citations
39 Claims
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1. A method for monitoring a patient undergoing treatment for cancer, comprising:
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positioning at least one wireless sensor in tissue in a region of interest in the body of a patient being treated for cancer;
administering a therapeutic radiolabeled analyte to the patient;
detecting in vivo from the at least one sensor a signal corresponding to radiation in the region of interest in the patient responsive to the administering step;
relaying the signal to a location external of the patient'"'"'s body; and
monitoring the signal over time to determine the localized response of the patient to the administered analyte to provide patient-specific response data that can be used to develop a patient specific cancer treatment strategy and/or evaluate the clinical efficacy of the treatment in the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A detection system for detecting radiation emitted from an internally administered radiolabeled analyte, comprising:
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at least one wireless implanted radiation sensor contigtzred for in vivo operation, the at least one sensor being configured to directly and/or indirectly detect beta radiation from an internally administered beta radiolabeled analyte proximate to a targeted cancer treatment site in the body, wherein the at least one sensor is configured to detect, at least intermittently, over a period of desired time; and
an external reader operably associated with the at least one radiation sensor and configured to receive signal data associated with the direct and/or indirectly detected radiation from the at least one sensor, wherein said system is configured to dynamically monitor selected in vivo parameters associated with one or more of the dose, uptake and/or processing of the radiation from the internally administered radiolabeled analyte at the targeted cancer treatment site. - View Dependent Claims (25, 26, 27, 28, 29, 30)
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31. A computer program product for evaluating radiation dose received at a target treatment site from a radiolabeled analyte administered in response to a cancer treatment regimen, said computer program product comprising:
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computer readable program code for receiving a plurality of measurements of radiation detected in vivo in tissue from a chronically implanted sensor located about a local targeted cancer treatment site in the body of a human subject undergoing treatment for cancer, the detected radiation corresponding to radiation emitted from a selected beta radiolabeled analyte administered internally to the subject; and
computer readable program code for computing one or more of a patient specific in vivo radiation dose, uptake, or processing of the radiolabeled analyte received at a cancer treatment site in a human subject based on the plurality of received measurements. - View Dependent Claims (32, 33, 34, 35, 36, 37)
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38. A method for monitoring a patient undergoing treatment for cancer, comprising:
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positioning at least one wireless sensor in tissue in a region of interest in the body of a patient being treated for cancer;
administering a therapeutic radioactive analyte internally to the patient;
detecting in vivo from the at least one sensor a signal corresponding to radiation in the region of interest in the patient responsive to the administering step;
relaying the signal to a location external of the patient'"'"'s body; and
monitoring the signal over time to determine the localized response of the patient to the administered analyte to provide patient-specific response data that can be used to develop a patient specific cancer treatment strategy and/or evaluate the clinical efficacy of the treatment in the patient. - View Dependent Claims (39)
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Specification