Biologic replacement for fibrin clot

• US 6,964,685 B2
• Filed: 07/27/2001
• Issued: 11/15/2005
• Est. Priority Date: 06/22/1999
• Status: Expired due to Term

• Current Assignee: Children's Medical Center Corporation
• Original Assignee: Brigham and Women's Hospital Incorporated
• Inventors: Marler, Jennifer, Murray, Michael F., Murray, Martha M.
• Primary Examiner(s): Pellegrino, Brian E.
• Application Number:
  US09/917,058
• Publication Number:
  US 20020123805A1
• Time in Patent Office: 1,572 Days
• Field of Search: 623/13.17, 623/14.12, 623/23.72, 623/23.76, 623/925, 623/917, 424/423, 514/801, 514/18, 606/214, 606/215
• US Class Current: 623/13.17
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 24/102 Collagen
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 2430/10 for reconstruction of tendons or ligaments
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/3616 Blood, e.g. platelet-rich plasma
• CPC Class Codes: A61L 27/3645 Connective tissue
• CPC Class Codes: A61L 27/365 Bones
• CPC Class Codes: A61L 27/3654 Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/3662 Ligaments, tendons
• CPC Class Codes: A61L 27/3804 characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/3843 Connective tissue
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C08L 89/06 : derived from leather or skin , e.g. gelatin
• CPC Class Codes: Y10S 623/917 : Collagen

Abstract

The invention provides compositions and methods for repairing intra-articular and extra-articular tissue including ligament, meniscus, cartilage, tendon, and bone. The method includes contacting the ends of an injured tissue from a patient with a composition. The repair composition includes soluble type 1 collagen, a platelet, and at least one of an extracellular protein and a neutralizing agent.

Claims

1. A method of treating an intra-articular injury by an arthroscopic procedure in a subject, the method comprising:

contacting the ends of a ruptured intra-articular tissue having an intrasynovial environment from the subject with a composition comprising soluble type I collagen, a platelet, and at least one of an extracellular matrix protein and a neutralizing agent.

2. The method of claim 1, wherein the intra-articular injury is a meniscal tear, ligament tear or a cartilage lesion.

3. The method of claim 1, further comprising mechanically joining the ends of the ruptured tissue.

4. The method of claim 1, wherein the extracellular matrix protein is selected from the group consisting of elastin, laminin, fibronectin, and entectin.

5. The method of claim 1, further comprising a gene therapy agent.

6. The method of claim 5, wherein the gene therapy agent includes a genetically altered cell.