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Methods for detecting nucleic acids indicative of cancer

  • US 6,964,846 B1
  • Filed: 04/07/2000
  • Issued: 11/15/2005
  • Est. Priority Date: 04/09/1999
  • Status: Expired due to Fees
First Claim
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1. A method for screening a patient for a colorectal cancer or a colorectal precancer, the method comprising the steps of:

  • detecting in a patient stool sample comprising exfoliated cells or cellular debris a first amount of a long nucleic acid of a length greater than 200 base pairs in length;

    wherein said long nucleic acid is present in both normal and cancerous or precancerous cells;

    comparing the first amount of long nucleic acid in said patient stool sample to a second amount of said long nucleic acid present in a stool sample from patient free of colorectal cancer or precancer;

    determining whether said first amount of long nucleic acid exceeds the second amount of long nucleic acid in said sample from a patient free of colorectal cancer or precancer; and

    ;

    identifying a positive screen for an indicator of a colorectal cancer or precancer if said amount of long nucleic acid in said patient stool sample does exceed said second amount of long nucleic acid in said sample from a patient free of colorectal cancer or precancer.

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