Nucleic acid labeling compounds
First Claim
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1. A nucleic acid labeling compound of the following structure:
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wherein A is a functional group that permits the attachment of the nucleic acid labeling compound to a nucleic acid;
X is O, S, NR1 or CHR2, wherein R1 and R2 are, independently, H, alkyl or aryl;
Y is H, N3, F, OR9, SR9 or NHR9, wherein R9 is H, alkyl or aryl;
Z is H, N3, F or OR10, wherein R10 is H, alkyl or aryl;
L is a linker moeity;
Q is a detectable moiety; and
M is a connecting group, wherein m is an integer ranging from 0 to about 3.
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Abstract
Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.
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Citations
13 Claims
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1. A nucleic acid labeling compound of the following structure:
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wherein A is a functional group that permits the attachment of the nucleic acid labeling compound to a nucleic acid;
X is O, S, NR1 or CHR2, wherein R1 and R2 are, independently, H, alkyl or aryl;
Y is H, N3, F, OR9, SR9 or NHR9, wherein R9 is H, alkyl or aryl;
Z is H, N3, F or OR10, wherein R10 is H, alkyl or aryl;
L is a linker moeity;
Q is a detectable moiety; and
M is a connecting group, wherein m is an integer ranging from 0 to about 3. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification