Investigating different physical and/or chemical forms of materials
First Claim
1. A method of investigating different physical and/or chemical forms of a material, the method being for undertaking an investigation selected from the group comprising:
- investigating polymorphs of a material;
investigating isomers of a material in a manner which allows different isomeric forms to be resolved;
investigating different hydrates/solvates of a material;
or investigating different salts of a material;
the method comprising;
providing an array of receptacles each containing material (hereinafter “
said initial material”
) to be investigated;
subjecting said initial material in respective different receptacles to respective different treatments under the control of a computer; and
analysing any material resulting from said different treatments (hereinafter “
said resultant material”
).
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Accused Products
Abstract
Apparatus and a method are described for investigating polymorphs of a material, isomers of a material which allow different isomeric forms to be resolved, different hydrates/solvates and/or different salts of a material. The apparatus comprises an assembly (2) of reactor devices (6) arranged within a reactor body (8) which incorporates a heating/cooling block (10) and a stirrer block (12). A vessel support block (14) supports respective sample vessels (15) below each reactor device (6) for recieving material from the reactor devices. The apparatus includes a control unit (4) which includes a computer (16) which controls a robot for delivering materials to the reactor devices; a heating/cooling unit (18); a stirrer control unit (20); and a pressure unit (22) which controls the passage of material from the reactor devices (6) to the sample vessels (15).
55 Citations
50 Claims
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1. A method of investigating different physical and/or chemical forms of a material, the method being for undertaking an investigation selected from the group comprising:
-
investigating polymorphs of a material;
investigating isomers of a material in a manner which allows different isomeric forms to be resolved;
investigating different hydrates/solvates of a material;
orinvestigating different salts of a material;
the method comprising;
providing an array of receptacles each containing material (hereinafter “
said initial material”
) to be investigated;
subjecting said initial material in respective different receptacles to respective different treatments under the control of a computer; and
analysing any material resulting from said different treatments (hereinafter “
said resultant material”
). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 42, 43, 44)
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25. A method of examining the effects in a treatment of a material of varying selected treatment variables, the method comprising preparing a first resultant material from an initial material using a first treatment using a first set of experimental variables and preparing a second resultant material from an initial material using a second treatment using a second set of experimental variables, wherein said first and second treatments are controlled by a computer.
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26. An apparatus for investigating different physical and/or chemical forms of a material, the apparatus comprising:
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an array of receptacles for containing material (hereinafter “
initial material”
) to be investigated;
treatment means for subjecting initial material to respective different treatments; and
a computer arranged to control the respective different treatments to which initial material is subjected; and
wherein means for condensing vapour is associated with said receptacles for reducing loss of material therefrom by evaporation. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33)
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34. An apparatus for investigating different physical and/or chemical forms of a material, the apparatus comprising:
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an array of receptacles for containing material (hereinafter initial material) to be investigated;
treatment means for subjecting initial material to respective different treatments;
a computer arranged to control the respective different treatments to which initial material is subjected;
wherein delivery means is provided for delivering materials into the receptacles, said delivery means being arranged to select materials from a material supply means and deliver selected materials to a selected receptacle in a predetermined amount and at a predetermined time. - View Dependent Claims (35, 36, 37)
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38. An apparatus for investigating different physical and/or chemical forms of a material, the apparatus comprising:
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an array of receptacles for containing material (hereinafter “
initial material”
) to be investigated;
treatment means for subjecting initial material to respective different treatments; and
a computer arranged to control the respective different treatments to which initial material is subjected;
wherein said apparatus includes input means for inputting analytical data relating to material produced after treatment of said initial material into said computer, wherein said computer is programmed to analyse data input into it and determine variables to be used in a subsequent investigation on the same initial material, using said apparatus. - View Dependent Claims (39, 40, 41)
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45. A method of investigating different physical and/or chemical forms of a material, the method comprising:
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providing an array of receptacles each containing material (hereinafter “
said initiai material”
) to be investigated;
subjecting said initial material in respective different receptacles to respective different treatments under the control of a computer;
analysing any material resulting from said different treatments (hereinafter “
said resultant material”
); and
investigating polymorphs of said initial material. - View Dependent Claims (46)
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47. A method of investigating different physical and/or chemical forms of a material, the method comprising:
-
providing an array of receptacles each containing material (hereinafter “
said initial material”
) to be investigated;
subjecting said initial material in respective different receptacles to respective different treatments under the control of a computer; and
analysing any material resulting from said different treatments (hereinafter “
said resultant material”
);
wherein the method is for the resolution of isomers of said initial material and includes the steps of;
treating the initial material with a range of potential salt forming materials (hereinafter “
salt formers”
) with a view to preparing salts of said initial materials;
subjecting the materials in said receptacles to different treatments; and
, after such treatments, analysing the resultant material or liquid removed from said receptacles.
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48. A method of investigating different physical and/or chemical forms of a material, the method comprising:
-
providing an array of receptacles each containing material (hereinafter “
said initial material”
) to be investigated;
subjecting said initial material in respective different receptacles to respective different treatments under the control of a computer; and
analysing any material resulting from said different treatments (hereinafter “
said resultant material”
)the method being for investigating different salts of a material and comprising the steps of treating the initial material with a range of potential salt forming materiais (hereinafter “
salt formers”
) and subjecting the materials to different treatments with a view to re-crystallising the salts of the initial material; and
, thereafter, analysing the resultant materials.
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49. A method of investigating different physical and/or chemical forms of a material, the method being for undertaking an investigation selected from the group comprising:
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investigating polymorphs of a material;
investigating isomers of a material in a manner which allows different isomeric forms to be resolved;
investigating different hydrates/solvates of a material;
orinvestigating different salts of a material;
the method comprising;
providing an array of receptacles each having a lower wall and each containing material (hereinafter “
said initial material”
) to be investigated supported on a respective lower wall;
subjecting said initial material in respective different receptacles to respective different treatments under the control of a computer; and
analysing any material resulting from said different treatments (hereinafter “
said resultant material”
).
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50. A method of investigating different physical and/or chemical forms of a material, the method being for undertaking an investigation selected from the group comprising:
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investigating polymorphs of a material;
investigating isomers of a material in a manner which allows different isomeric forms to be resolved;
investigating different hydrates/solvates of a material;
orinvestigating different salts of a material;
the method comprising;
providing an array of receptacles each containing material (hereinafter “
said initial material”
) to be investigated, wherein said initial material is a solid;
subjecting said initial material in respective different receptacles to respective different treatments under the control of a computer; and
analysing any material resulting from said different treatments (hereinafter “
said resultant material”
).
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Specification