Method and apparatus for an automated procedure to detect and monitor early-stage glaucoma

• US 6,966,650 B2
• Filed: 06/27/2003
• Issued: 11/22/2005
• Est. Priority Date: 06/27/2003
• Status: Expired due to Term

• Current Assignee: Vance Marc Zemon, Zongqi Hu
• Original Assignee: Vance Marc Zemon, Zongqi Hu
• Inventors: Hu, Zongqi, Zemon, Vance Marc
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): SANDERS JR, JOHN R
• Application Number:
  US10/608,627
• Publication Number:
  US 20040263780A1
• Time in Patent Office: 879 Days
• Field of Search: 351/205, 351/211, 351/221, 351/222, 351/237, 351/246, 600/544, 600/545, 600/558
• US Class Current: 351/205
• CPC Class Codes: A61B 3/10 Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
• CPC Class Codes: A61B 5/378 Visual stimuli

Abstract

A system and a method for automated, electrophysiological assessment of visual function in glaucoma suspects and patients is provided using visual evoked potentials measured in response to periodic stimuli presented to the patients. The method may be comprised of the steps of entering a patient'"'"'s information into a computer, initializing a visual stimulus for the patient, recording a plurality of visual evoked potential signals obtained from one or more electrodes attached to the patient'"'"'s scalp, saving and processing digitized data relating to the visual evoked potential signals, and determining if the likelihood of glaucoma is high or low based on the data.

Claims

1. A method for performing a medical test associated with glaucoma comprising

displaying a plurality of visual stimuli for observation by one eye of a patient;

detecting the patient'"'"'s evoked brain potential signals in response to said stimuli through one or more electrodes attached to the patient'"'"'s scalp;

recording said evoked brain potential signals detected for each stimulus displayed;

performing an automatic digital signal processing for a plurality of said recorded evoked brain potential signals following the recording;

displaying an indication of whether there is a high or low likelihood of glaucoma on a computer monitor based on said digital signal processing;

further wherein

the digital signal processing comprises

obtaining a plurality of fundamental frequency components of a plurality of the evoked brain potential signals corresponding to the periodic visual stimuli;

performing a statistical method to determine a signal-to-noise ratio for said plurality of fundamental frequency components;

comparing said signal-to-noise ratio with a preset critical value; and

determining if the likelihood of glaucoma is high or low based on said comparison.

2. The method of claim 1 wherein

the visual stimulus is comprised of two patterns, an isolated check pattern and a uniform field pattern, displayed alternately in a periodic manner at a frequency of about twelve Hertz.

3. The method of claim 1 wherein

the recording comprises

amplifying said evoked brain potential signals detected from said one or more electrodes attached to the patient'"'"'s scalp;

converting said evoked brain potential signals amplified from analog signals to digital signals.

4. The method of claim 1 further comprises

an automated procedure for evoked brain potential signal recording and digital signal processing;

wherein

a computer processor controls both said evoked brain potential signal recording and said digital signal processing; and

the computer processor initiates said digital signal processing immediately following the completion of said evoked brain potential signal recording.

5. The method of claim 1 further wherein

the digital signal processing comprises

performing a Discrete Fourier Transform on the plurality of the evoked brain potential signals recorded to obtain a plurality of fundamental frequency components of a plurality of the evoked brain potential signals corresponding to the periodic visual stimuli.

6. The method of claim 5 wherein

the statistical method is a T²_circle method.

7. An apparatus for performing a medical test associated with glaucoma comprising

a computer processor;

a visual stimulus generating device for presenting visual stimuli to a patient;

a visual evoked potential recording and measuring device;

a computer monitor; and

a computer memory;

wherein

the computer processor is programmed by computer software residing in the computer memory to;

display a set of visual stimuli on said visual stimulus generating device for observation by a patient;

control said recording and measuring device to record a plurality of visual evoked potential signals in response to said set of visual stimuli detected from one or more electrodes attached to the patients scalp;

perform digital signal processing on the plurality of visual evoked potential signals recorded; and

display an indication of whether there is a high or low likelihood of glaucoma on said computer monitor based on said digital signal processing; and

further wherein

the digital signal processing comprises

obtaining a plurality of fundamental frequency components of a plurality of the evoked brain potential signals corresponding to the periodic visual stimuli;

performing a statistical method to determine a signal-to-noise ratio for said plurality of fundamental frequency components;

comparing said signal-to-noise ratio with a preset critical value; and

determining if the likelihood of glaucoma is high or low based on said comparison.

8. The apparatus of claim 7 wherein

the visual stimulus generating device is comprised of a graphics card and a video monitor.

9. The apparatus of claim 7 wherein

the set of visual stimuli is comprised of an isolated check pattern and a uniform field pattern, displayed alternately in a periodic manner at a frequency of about twelve Hertz;

and

wherein the frequency and displaying alternately in a periodic manner is controlled by said computer software.

10. The apparatus of claim 7 wherein

the visual evoked potential recording and measuring device comprises

an amplifier that enlarges the visual evoked potential signals detected from one or more electrodes attached to the patient'"'"'s scalp;

an analog to digital converter that converts said amplified visual evoked potential signals to digital signals, and provides said digital signals to the computer processor; and

wherein

the analog to digital converter has a digital sampling rate that is controlled by said computer processor.

11. The apparatus of claim 7 further wherein

the digital signal processing comprises

performing a Discrete Fourier Transform on the plurality of recorded visual evoked potential signals to obtain the plurality of fundamental frequency components of the plurality of the recorded visual evoked potential signals data corresponding to the periodic visual stimuli.

12. The apparatus of claim 11 wherein

the statistical method is a T²_circle method.