Methods and device for non-invasive analyte measurement
First Claim
1. A method of determining an analyte concentration in a tissue of a subject, the subject including an eye with an ocular surface and a conjunctiva surface, comprising the steps:
- a. exposing at least a portion of the conjunctiva surface of the subject to mid-infrared radiation without contact with the ocular surface;
b. detecting mid-infrared radiation reflected from the conjunctiva without contact with the ocular surface; and
,c. determining a radiation signature of said reflected mid-infrared radiation to determine an analyte concentration in a tissue of said subject.
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Accused Products
Abstract
The present invention is related to optical non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject'"'"'s body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods a body surface of the subject, such as the subject'"'"'s eye, with radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.
166 Citations
14 Claims
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1. A method of determining an analyte concentration in a tissue of a subject, the subject including an eye with an ocular surface and a conjunctiva surface, comprising the steps:
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a. exposing at least a portion of the conjunctiva surface of the subject to mid-infrared radiation without contact with the ocular surface; b. detecting mid-infrared radiation reflected from the conjunctiva without contact with the ocular surface; and
,c. determining a radiation signature of said reflected mid-infrared radiation to determine an analyte concentration in a tissue of said subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An instrument for determining an analyte concentration in a tissue of a subject, the subject including an eye with an ocular surface and a conjunctiva surface, comprising:
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a. a radiation source configured to expose at least a portion of the conjunctiva surface of the subject to mid-infrared radiation without contact with the ocular surface; b. a mid-infrared radiation wavelength detector configured to detect mid-infrared radiation reflected from the conjunctiva without contact with the ocular surface; c. a display for alphanumeric or audio representations of an analyte concentration in a tissue of said subject based on a determined radiation signature of said reflected mid-infrared radiation; and d. a microprocessor for correlating said detected mid-infrared radiation with wavelengths corresponding to said analyte concentration and analyzing said wavelengths to calculate said analyte concentration in said tissue. - View Dependent Claims (12)
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13. An instrument for determining an analyte concentration in a tissue of a subject, the subject including an eye with an ocular surface and a conjunctiva surface, comprising:
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a. a radiation source of mid-infrared radiation within the range of about 2.5 to about 25.0 microns configured to expose at least a portion of the conjunctiva surface of the subject to mid-infrared radiation without contact with the ocular surface; and b. a mid-infrared radiation detector configured to detect mid-infrared radiation reflected from the conjunctiva without contact with the ocular surface within a wavelength range of between about 8.0 to about 11.0 microns; and c. a microprocessor for correlating said reflected mid-infrared radiation with a radiation signature corresponding to an analyte concentration and analyzing said radiation signature to calculate said analyte concentration in said tissue of said subject. - View Dependent Claims (14)
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Specification