Protective assembly

• US 6,971,391 B1
• Filed: 02/24/2003
• Issued: 12/06/2005
• Est. Priority Date: 12/18/2002
• Status: Expired due to Fees

• Current Assignee: Biophan Technologies Incorporated
• Original Assignee: Nanoset LLC
• Inventors: Gray, Robert W., Helfer, Jeffrey L., Wang, Xingwu, Greenwald, Howard J.
• Primary Examiner(s): Dahbour, Fadi H.
• Application Number:
  US10/373,377
• Time in Patent Office: 1,016 Days
• Field of Search: 128/846, 607 96-156, 607 2- 38, 607 63- 64, 606 27- 52, 601 2- 5, 600/407, 600410-423
• US Class Current: 128/846
• CPC Class Codes: A61N 1/16 Screening or neutralising undesirable influences from or using, atmospheric or terrestrial radiation or fields using atmospheric electricity or earth currents H05F3/00
• CPC Class Codes: B82Y 25/00 Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
• CPC Class Codes: H01B 11/10 Screens specially adapted for reducing interference from external sources
• CPC Class Codes: H01F 1/0063 in a non-magnetic matrix, e.g. granular solids granular films H01F10/007
• CPC Class Codes: H01F 10/007 ultrathin or granular films H01F10/005 and H01F10/3227 take precedence; applying ultrathin or granular layers to substrates H01F41/301
• CPC Class Codes: H01F 10/324 Exchange coupling of magnetic film pairs via a very thin non-magnetic spacer, e.g. by exchange with conduction electrons of the spacer
• CPC Class Codes: Y10T 428/24992 Density or compression of components
• CPC Class Codes: Y10T 428/25 Web or sheet containing structurally defined element or component and including a second component containing structurally defined particles
• CPC Class Codes: Y10T 428/27 Web or sheet containing structurally defined element or component, the element or component having a specified weight per unit area [e.g., gms/sq cm, lbs/sq ft, etc.]
• CPC Class Codes: Y10T 428/2982 Particulate matter [e.g., sphere, flake, etc.]

Abstract

An assembly for protecting biological tissue from the effects of heating. The assembly contains a conductor in contact with the biological tissue and forming an electrical circuit comprising the biological tissue. The assembly contains a device for modifying the impedance of the electrical circuit such that, at a frequency of from about 10 megahertz to about 150 megahertz, such impedance is at least about 0.5 ohms per centimeter of length of said conductor. The assembly also contains a device for limiting the flow of current through the biological tissue such that, when the assembly is exposed to an alternating current electromagnetic field at a frequency of 64 megahertz and a magnetic field strength of 1.5 Tesla for 15 minutes, the temperature of the biological tissue does not exceed 42 degrees Celsius.

Claims

1. An assembly for protecting biological tissue from the effects of heating comprising a conductor in contact with said biological tissue and forming an electrical circuit comprising said biological tissue, wherein said assembly is comprised of means for modifying the impedance of said electrical circuit such that, at a frequency of from about 20 megahertz to about 150 megahertz, said impedance is at least about 0.5 ohms per centimeter of length of said conductor, and wherein said assembly is comprised of means for limiting the flow of current through said tissue such that, when said assembly is exposed to an alternating electromagnetic wave at a frequency of 64 megahertz and a direct current magnetic field strength of 1.5 Tesla for at least about 15 minutes, the temperature of said biological tissue does not exceed 42 degrees Celsius.

2. The assembly as recited in claim 1 wherein, when said assembly is exposed to an alternating electromagnetic wave at a frequency of 64 megahertz and a direct current magnetic field strength of 1.5 Tesla for at least about 15 minutes, the temperature of said biological tissue does not exceed 39 degrees Celsius.

3. The assembly as recited in claim 1, wherein, at a frequency of from about 50 to about 70 megahertz, said impedance is at least about 2 ohms per centimeter of length of said conductor.

4. The assembly as recited in claim 3, wherein said assembly further comprises a means for cooling said biological tissue.

5. The assembly as recited in claim 3, wherein said assembly further comprises a magnetic shield.

6. The assembly as recited in claim 1, wherein said means for limiting current flow through said biological tissue comprises an a radio frequency choke electrically connected to said conductor.

7. An assembly for protecting biological tissue from the effects of heating comprising a conductor in contact with said biological tissue and forming an electrical circuit comprising said biological tissue, wherein said assembly is comprised of means for limiting the flow of current through said tissue such that, when said assembly is exposed to an alternating electromagnetic wave at a frequency of 64 megahertz and a direct current magnetic field strength of from about 1.5 Tesla for at least about 15 minutes, the temperature of said biological tissue does not exceed 39 degrees Celsius, wherein said assembly is a magnetically shielded assembly comprised of a medical device implanted in a biological organism, wherein said medical device is disposed near said biological tissue, and wherein said magnetically shielded assembly is comprised of a magnetic shield disposed on at least a portion of said medical device.

8. The assembly as recited in claim 7, wherein said magnetic shield is comprised of a first layer of nanomagnetic material.

9. The assembly as recited in claim 8, wherein:

said first layer of nanomagnetic material has a thickness of at least about 150 nanometers, a mass density of at least about 0.001 grams per cubic centimeter, a saturation magnetization of from about 1 to about 36,000 Gauss, a coercive force of from about 0.01 to about 5,000 Oersteds, and a relative magnetic permeability of from about 1 to about 500,000.

10. The assembly as recited in claim 9, wherein said first layer of nanomagnetic material has a thickness of from about 500 to about 1,000 nanometers.

11. The assembly as recited in claim 9, wherein said magnetic shield is disposed on at least a portion of an implantable medical lead.

12. The assembly as recited in claim 9, wherein said magnetic shield is disposed on at least a portion of a multiple strand conductor.

13. The assembly as recited in claim 9, wherein said first layer of nanomagnetic material is comprised of electrical circuitry.

14. The assembly as recited in claim 9, wherein said medical device is a catheter assembly.

15. The assembly as recited in claim 9, wherein said magnetic shield is comprised of a first layer of nanoelectrical material disposed around said first layer of nanomagnetic material, and wherein said first layer of nanoelectrical material has a thickness of from about 0.5 to about 2 microns and a resistivity of from about 1 to about 100 microohm-centimeters.

16. The assembly as recited in claim 9, wherein said magnetic shield is comprised of a first layer of nanothermal material disposed around said first layer of nanomagnetic material, and wherein said first layer of nanothermal material has a thermal conductivity of at least about 150 watts/meter-degree Kelvin and a resistivity of at least about 1010 microohm-centimeters.

17. The assembly as recited in claim 15, wherein said first layer of nanoelectrical material has a thermal conductivity of from about 1 to about 4 watts/centimeter-degrees Kelvin.

18. The assembly as recited in claim 17, further comprising a second layer of nanomagnetic material disposed around said first layer of nanoelectrical material, wherein said second layer of nanomagnetic material has a mass density of at least about 0.001 grams per cubic centimeter, a saturation magnetization of from about 1 to about 36,000 Gauss, a coercive force of from about 0.01 to about 5,000 Oersteds, and a relative magnetic permeability of from about 1 to about 500,000.

19. The assembly as recited in claim 17, further comprising a layer of nanothermal material disposed around said first layer of nanoelectrical material, wherein said first layer of nanothermal material has a thermal conductivity of at least about 150 watts/meter-degree Kelvin and a resistivity of at least about 10¹⁰ microohm-centimeters.

20. The assembly as recited in claim 18, wherein said assembly further comprises a layer of nanothermal material disposed around said second layer of nanomagnetic material, and wherein said layer of nanothermal material material has a thermal conductivity of at least about 150 watts/meter-degree Kelvin and a resistivity of at least about 10¹⁰ microohm-centimeters.

21. The assembly as recited in claim 9, wherein said magnetic shield further comprises antithrombogenic material.

22. An assembly for protecting biological tissue from the effects of induced voltages produced by high frequency electromagnetic radiation, wherein said assembly comprises a conductor and pulse generator in contact with said biological tissue and forming an electrical induction loop comprising said biological tissue, wherein said assembly is comprised of a magnetic shield disposed between said high frequency electromagnetic radiation and said conductor, and wherein said assembly is comprised of means for limiting the voltage induced in said electrical induction loop such that, when said high frequency electromagnetic radiation contacts said assembly, said induced voltage is less than about 0.5 volts.

23. The assembly as recited in claim 22, wherein said magnetic shield is comprised of nanomagnetic material.

24. The assembly as recited in claim 23, wherein said nanomagnetic material is present in the form of a first layer of nanomagnetic material with a thickness of at least about 150 nanometers.

25. The assembly as recited in claim 24, wherein said first layer of nanomagnetic material has a mass density of at least about 0.001 grams per cubic centimeter, a saturation magnetization of from about 1 to about 36,000 Gauss, a coercive force of from about 0.01 to about 5,000 Oersteds, and a relative magnetic permeability of from about 1 to about 500,000.

26. The assembly as recited in claim 25, wherein said first layer of nanomagnetic material has a thickness of from about 500 to about 1,000 nanometers.

27. The assembly as recited in claim 25, wherein said magnetic shield is disposed on at least a portion of an implantable medical lead.

28. The assembly as recited in claim 25, wherein said wherein said magnetic shield is disposed on at least a portion of a multiple strand conductor.

29. The assembly as recited in claim 25, wherein said magnetic shield is disposed on at least a portion of a multifilar coiled conductor.

30. The assembly as recited in claim 25, wherein said magnetic shield is disposed on at least a portion of a monfilar coiled conductor.

31. The assembly as recited in claim 25, wherein said first layer of nanomagnetic material is comprised of electrical circuitry.

32. The assembly as recited in claim 25, wherein said means for means for limiting the voltage induced in said electrical induction loop is comprised of electrical circuitry.

41. The assembly as recited in claim 24, wherein said wherein said magnetic shield is comprised of a first layer of nanoelectrical material disposed around said first layer of nanomagnetic material, wherein:

said first layer of nanoelectrical material has a thickness of from about 0.5 to about 2 microns and a resistivity of from about 1 to about 100 microohm-centimeters.

43. The magnetically shielded assembly as recited in claim 41, further comprising a second layer of nanomagnetic material disposed around said first layer of nanoelectrical material, wherein said second layer of nanomagnetic material has a mass density of at least about 0.001 grams per cubic centimeter, a saturation magnetization of from about 1 to about 36,000 Gauss, a coercive force of from about 0.01 to about 5,000 Oersteds, and a relative magnetic permeability of from about 1 to about 500,000.

44. The assembly as recited in claim 24, wherein said magnetic shield further comprises antithrombogenic material.

33. An assembly for protecting biological tissue from the effects of induced voltages produced by high frequency electromagnetic radiation, wherein said assembly comprises a medical device in contact with said biological tissue and forming an electrical induction loop comprising said biological tissue, wherein said assembly is comprised of a magnetic shield disposed between said high frequency electromagnetic radiation and said medical device, and wherein said assembly is comprised of means for limiting the voltage induced in said electrical induction loop such that, when said high frequency electromagnetic radiation contacts said assembly, said induced voltage is less than about 0.5 volts.

34. The assembly as recited in claim 33, wherein said medical device is a cathether assembly.

35. The assembly as recited in claim 33, wherein said medical device is a guidewire.

36. The assembly as recited in claim 33, wherein said medical device is a stylet.

37. The assembly as recited in claim 33, wherein said medical device is a transesophagal medical lead.

38. The assembly as recited in claim 33, wherein a sheath is disposed over said medical device.

39. The assembly as recited in claim 38, wherein said magnetic shield is disposed over said sheath.

40. The assembly as recited in claim 33, wherein said wherein said magnetic shield is comprised of a first layer of nanoelectrical material disposed around said first layer of nanomagnetic material, wherein:

said first layer of nanoelectrical material has a thickness of from about 0.5 to about 2 microns and a resistivity of from about 1 to about 100 microohm-centimeters.

42. The magnetically shielded assembly as recited in claim 40, further comprising a second layer of nanomagnetic material disposed around said first layer of nanoelectrical material, wherein said second layer of nanomagnetic material has a mass density of at least about 0.001 grams per cubic centimeter, a saturation magnetization of from about 1 to about 36,000 Gauss, a coercive force of from about 0.01 to about 5,000 Oersteds, and a relative magnetic permeability of from about 1 to about 500,000.

45. The assembly as recited in claim 33, wherein said magnetic shield further comprises antithrombogenic material.