Sensor
First Claim
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1. A sensor for use in the detection of an analyte in a fluid, the sensor comprising:
- a tube defining a flow path for the fluid;
a generally planar member having opposed faces mounted in the flow path such that the plane is in the direction of flow, wherein the member has, bound thereto, in separate areas, a ligand and a reference compound, wherein the ligand interacts with the analyte, and wherein the interaction causes different stresses to act on the opposed faces of the member, thereby causing the member to flex;
means for the detection of the flexing; and
means for distinguishing between the ligand signal and the reference compound signal, whereby common mode noise can be determined.
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Abstract
The present invention pertains to a sensor, suitable for use in the detection of an analyte in a fluid, comprising: a tube (4) defining a flow path for the fluid; a generally planar member (3) mounted in the flow path (→) such that the plane is in the direction of flow, wherein the member has, bound thereto, a ligand that interacts with the analyte, wherein interaction causes the member to flex; and means (1, 2) for the detection of the flexing.
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Citations
14 Claims
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1. A sensor for use in the detection of an analyte in a fluid, the sensor comprising:
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a tube defining a flow path for the fluid; a generally planar member having opposed faces mounted in the flow path such that the plane is in the direction of flow, wherein the member has, bound thereto, in separate areas, a ligand and a reference compound, wherein the ligand interacts with the analyte, and wherein the interaction causes different stresses to act on the opposed faces of the member, thereby causing the member to flex; means for the detection of the flexing; and means for distinguishing between the ligand signal and the reference compound signal, whereby common mode noise can be determined. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for screening a target compound with respect to a plurality of analytes in a fluid, which comprises:
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causing the analytes to flow through the tube of a sensor, wherein the sensor comprises a tube defining a flow path for the fluid;
a generally planar member having opposed faces mounted in the flow path such that the plane is in the direction of flow, wherein the member has, bound thereto, in separate areas, a ligand and a reference compound, the target compound being the ligand, wherein the ligand interacts with the analyte, and wherein the interaction causes different stresses to act on the opposed faces of the member, thereby causing the member to flex;
means for the detection of the flexing; and
means for distinguishing between the ligand signal and the reference compound signal, whereby common mode noise can be determined; anddetecting any flexing of the member. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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Specification